Search Results - "Vermeulen, John"

Discovery of 2‑[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia by Kelly, Martha J, Pietranico-Cole, Sherrie, Larigan, J. Douglas, Haynes, Nancy-Ellen, Reynolds, Charles H, Scott, Nathan, Vermeulen, John, Dvorozniak, Mark, Conde-Knape, Karin, Huang, Kuo-Sen, So, Sung-Sau, Thakkar, Kshitij, Qian, Yimin, Banner, Bruce, Mennona, Frank, Danzi, Sara, Klein, Irwin, Taub, Rebecca, Tilley, Jefferson

“…The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while…”
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C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase by Pietranico, Sherrie L., Foley, Louise H., Huby, Nicholas, Yun, Weiya, Dunten, Pete, Vermeulen, John, Wang, Ping, Toth, Katherine, Ramsey, Gwendolyn, Gubler, Mary-Lou, Wertheimer, Stanley J.

“…Enzyme and cellular assay results for a number of new modifications on the C-8 aminobenzyl unit are reported. Pyrazole sulfonic acid amide analogs are shown to…”
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