Search Results - "Verma, Rati"

Harnessing the Power of Proteolysis for Targeted Protein Inactivation by Verma, Rati, Mohl, Dane, Deshaies, Raymond J.

“…Two decades into the twenty-first century, a confluence of breakthrough technologies wielded at the molecular level is presenting biologists with unique…”
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Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome by Verma, Rati, Oania, Robert S, Kolawa, Natalie J, Deshaies, Raymond J

“…Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during…”
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Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System by Verma, Rati, Oania, Robert, Graumann, Johannes, Deshaies, Raymond J

“…Recruitment of ubiquitinated proteins to the 26S proteasome lies at the heart of the ubiquitin-proteasome system (UPS). Genetic studies suggest a role for the…”
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Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units by Singh, Nitesh Kumar, Singh, Nishant K, Verma, Rati, Diwan, Ashish D

“…(1) Background: Intervertebral disc degeneration has been linked to obesity; its potential mechanical effects on the intervertebral disc remain unknown. This…”
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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase by Kaiser, Peter, Huang, Jing, Aghajan, Mariam, Jonai, Nao, Flick, Karin, Fu, Fei, Luo, Manlin, Cai, Xiaolu, Ouni, Ikram, Pierce, Nathan, Tang, Xiaobo, Lomenick, Brett, Damoiseaux, Robert, Hao, Rui, del Moral, Pierre M, Verma, Rati, Li, Ying, Li, Cheng, Houk, Kendall N, Jung, Michael E, Zheng, Ning, Huang, Lan, Deshaies, Raymond J

“…The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in…”
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Comparison between all-on-four and all-on-six treatment concepts on stress distribution for full-mouth rehabilitation using three-dimensional finite element analysis: A biomechanical study by Pandey, Aishwarya, Durrani, Farhan, Rai, Sanjay, Singh, Nishant, Singh, Preeti, Verma, Rati, Kumar, Jitendra

“…Purpose: The current study intended to provide a comparison of biomechanical behaviors of two different treatment concepts for full-mouth rehabilitation with…”
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Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation by Sakamoto, Kathleen M, Kim, Kyung B, Verma, Rati, Ransick, Andy, Stein, Bernd, Crews, Craig M, Deshaies, Raymond J

“…The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these…”
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Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes by Verma, R, Chen, S, Feldman, R, Schieltz, D, Yates, J, Dohmen, J, Deshaies, R J

“…Ubiquitin-dependent proteolysis is catalyzed by the 26S proteasome, a dynamic complex of 32 different proteins whose mode of assembly and mechanism of action…”
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Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain by Verma, Rati, Peters, Noel R., D'Onofrio, Mariapina, Tochtrop, Gregory P., Sakamoto, Kathleen M., Varadan, Ranjani, Zhang, Mingsheng, Coffino, Philip, Fushman, David, Deshaies, Raymond J., King, Randall W.

“…To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of…”
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Evaluation and comparison of stress distribution around periodontally compromised mobile teeth splinted with different materials: Three-dimensional finite element analysis by Durrani, Farhan, Galohda, Arpit, Rai, Sanjay, Singh, Nishant, Verma, Rati, Yadav, Dhananjay, Karthickraj, S

“…Background: Progressive attachment loss around the teeth because of periodontal disease can result in increased tooth mobility. This adversely affects…”
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Mutations in the Hydrophobic Core of Ubiquitin Differentially Affect Its Recognition by Receptor Proteins by Haririnia, Aydin, Verma, Rati, Purohit, Nisha, Twarog, Michael Z., Deshaies, Raymond J., Bolon, Dan, Fushman, David

“…Ubiquitin (Ub) is one of the most highly conserved signaling proteins in eukaryotes. In carrying out its myriad functions, Ub conjugated to substrate proteins…”
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Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes by Verma, Rati, Reichermeier, Kurt M., Burroughs, A. Maxwell, Oania, Robert S., Reitsma, Justin M., Aravind, L., Deshaies, Raymond J.

“…Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain…”
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Charting the Protein Complexome in Yeast by Mass Spectrometry by Deshaies, Raymond J, Seol, Jae Hong, McDonald, W Hayes, Cope, Greg, Lyapina, Svetlana, Shevchenko, Andrej, Shevchenko, Anna, Verma, Rati, Yates, 3rd, John R

“…It has become evident over the past few years that many complex cellular processes, including control of the cell cycle and ubiquitin-dependent proteolysis,…”
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Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II by Verma, Rati, Oania, Robert, Fang, Ruihua, Smith, Geoffrey T., Deshaies, Raymond J.

“…Cdc48/p97 is an essential ATPase whose role in targeting substrates to the ubiquitin-proteasome system (UPS) remains unclear. Existing models posit that Cdc48…”
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Mechanical Property Analysis of Triply Periodic Minimal Surface Inspired Porous Scaffold for Bone Applications: A Compromise between Desired Mechanical Strength and Additive Manufacturability by Kumar, Jitendra, Verma, Rati, Singh, Nitesh Kumar, Singh, Nishant Kumar, Nirala, Neelam Shobha, Rai, Sanjay Kumar

“…Porous structure offers the advantage of minimizing stress shielding phenomena and supports bone ingrowth, thereby improving the long-term durability of…”
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The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics by Sherman, David J, Liu, Lei, Mamrosh, Jennifer L, Xie, Jiansong, Ferbas, John, Lomenick, Brett, Ladinsky, Mark S, Verma, Rati, Rulifson, Ingrid C, Deshaies, Raymond J

“…Nonalcoholic fatty liver disease, recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD), is a progressive metabolic disorder that…”
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Design, development and fluidic behavior analysis of triply periodic minimal surface (TPMS) based scaffolds for bone-applications by Kumar, Jitendra, Nirala, Neelam shobha, Singh, Nishant Kumar, Gupta, Nakul, Dwivedi, Yagya Dutta, Verma, Rati, Rai, Sanjay Kumar, Gupta, Manish

“…The fluidic behavior of porous scaffolds plays a vital role in the mass transportation of cells and the formation of new tissue, which is crucial for promoting…”
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Cks1 Is Required for G1Cyclin–Cyclin-Dependent Kinase Activity in Budding Yeast by Reynard, Gregory J., Reynolds, William, Verma, Rati, Deshaies, Raymond J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway by den Besten, Willem, Verma, Rati, Kleiger, Gary, Oania, Robert S, Deshaies, Raymond J

“…The AAA+ protein p97 and its UBA-UBX cofactors are thought to promote degradation by separating ubiquitinated proteins from membranes or protein complexes…”
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Abstract 3871: KRAS G12C mutant allele amplification drives resistance to sotorasib in vitro by Mohn, Deanna, Saiki, Anne Y., Achanta, Pragathi, Stapper, Andres Plata, Lipford, J. Russell, Verma, Rati

“…Abstract Sotorasib is an approved KRASG12C-selective inhibitor for the treatment of KRAS p.G12C-mutant advanced and previously treated non-small cell lung…”
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