Search Results - "Verkerk, AO"

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling by van den Hoogenhof, Maarten M.G, Beqqali, Abdelaziz, Amin, Ahmad S, van der Made, Ingeborg, Aufiero, Simona, Khan, Mohsin A.F, Schumacher, Cees A, Jansweijer, Joeri A, van Spaendonck-Zwarts, Karin Y, Remme, Carol Ann, Backs, Johannes, Verkerk, Arie O, Baartscheer, Antonius, Pinto, Yigal M, Creemers, Esther E

“…BACKGROUND:Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically aggressive form of dilated cardiomyopathy, with an increased risk of malignant…”
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Maturation of hiPSC-derived cardiomyocytes in cardiac microtissues promotes adult alternative splicing of sodium channel revealing mutation effects associated with cardiac arrhythmia by Campostrini, G, Ward-Van Oostwaard, D, Kosmidis, G, Verkerk, AO, Bezzina, CR, Mummery, CL, Bellin, M

“…Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): Marie Skłodowska-Curie Actions - Individual…”
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Mexiletine rescues the mixed phenotype in SCN5A-1795insD hiPSC-CMs by Nasilli, G, Yiangou, L, Palandri, C, Verkerk, AO, Davis, RP, Casini, S, Remme, CA

“…Abstract Funding Acknowledgements Type of funding sources: None. Background The sodium channel blocker mexiletine can reduce late sodium current (INa) in…”
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Electrophysiological changes in heart failure and their implications for arrhythmogenesis by Coronel, R., Wilders, Ronald, Verkerk, Arie O., Wiegerinck, Rob F., Benoist, David, Bernus, Olivier

“…Heart failure is the final common pathway of various cardiac pathologies and is associated with sudden cardiac death, mostly caused by ventricular arrhythmias…”
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TNNI3K delays atrioventricular conduction and reduces connexin-45 gap junctional coupling by Pham, C, Podliesna, S, Verkerk, AO, Wolswinkel, R, Munoz-Martin, N, Veldkamp, MW, Beekman, L, Wilde, LMW, Remme, CA, Bezzina, CR, Lodder, EM

“…Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Dutch Research Council (NWO…”
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Differential sodium current remodelling in human left atrial appendage cardiomyocytes in paroxysmal and persistent atrial fibrillation by Casini, S, Marchal, GA, Kawasaki, M, Fabrizi, B, Wesselink, R, Nariswari, FA, Neefs, J, Van Den Berg, NWE, Driessen, AHG, De Groot, JR, Verkerk, AO, Remme, CA

“…Abstract Funding Acknowledgements Type of funding sources: None. Background Atrial fibrillation (AF) is characterized by complex electrical, structural and…”
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Recurrent variant of unknown significance in KCNH2 classified through functional characterisation by Copier, JS, Bootsma, M, Wilde, AAM, Bertels, RA, Bikker, H, Christiaans, I, Koopmann, TT, Lommerse, AAJ, Bezzina, CR, Verkerk, AO, Barge-Schaapveld, DQCM, Lodder, EM

“…Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Dutch Research Council (NWO…”
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Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy by ten Hoope, Werner, Hollmann, Markus W, de Bruin, Kora, Verberne, Hein J, Verkerk, Arie O, Tan, Hanno L, Verhamme, Camiel, Horn, Janneke, Rigaud, Marcel, Picardi, Susanne, Lirk, Philipp

“…BACKGROUND:Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic…”
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Right ventricular fibrosis and conduction delay in a patient with clinical signs of brugada syndrome : A combined electrophysiological, genetic, histopathologic, and computational study by CORONEL, Ruben, CASINI, Simona, VAN DER WAL, Allard C, TAN, Hanno L, BRUGADA, Pedro, WILDE, Arthur A. M, DE BAKKER, Jacques M. T, KOOPMANN, Tamara T, WILMS-SCHOPMAN, Francien J. G, VERKERK, Arie O, DE GROOT, Joris R, BHUIYAN, Zahurul, BEZZINA, Connie R, VELDKAMP, Marieke W, LINNENBANK, André C

“…The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown. A BS patient without clinically detected cardiac structural…”
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Slow Delayed Rectifier Potassium Current Blockade Contributes Importantly to Drug-Induced Long QT Syndrome by Veerman, Christiaan C, Verkerk, Arie O, Blom, Marieke T, Klemens, Christine A, Langendijk, Pim N.J, van Ginneken, Antoni C.G, Wilders, Ronald, Tan, Hanno L

“…BACKGROUND—Drug-induced long QT syndrome is generally ascribed to inhibition of the cardiac rapid delayed rectifier potassium current (IKr). Effects on the…”
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P333HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy by Milano, A, Vermeer, AMC, Lodder, ER, Barc, J, Verkerk, AO, Van Der Bilt, IAC, Pinto, Y, Christiaans, I, Wilde, AA, Bezzina, CR

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Genetic control of sodium channel function by TAN, Hanno L, BEZZINA, Connie R, SMITS, Jeroen P. P, VERKERK, Arie O, WILDE, Arthur A. M

“…Sodium ion (Na) influx through cardiac Na channels triggers the action potential in cells of the working myocardium and the specialized conduction system. Na…”
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A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization by BEZZINA, Connie R, VERKERK, Arie O, LUFT, Friedrich C, SCHUNKERT, Heribert, WILDE, Arthur A. M, BUSJAHN, Andreas, JERON, Andreas, ERDMANN, Jeanette, KOOPMANN, Tamara T, BHUIYAN, Zahurul A, WILDERS, Ronald, MANNENS, Marcel M. A. M, TAN, Hanno L

“…Genetic variants of cardiac ion channels may influence cardiac repolarization. Thereby such variants may modulate the penetrance of primary electrical…”
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Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration by WIEGERINCK, Rob F, VERKERK, Arie O, BELTERMAN, Charly N, VAN VEEN, Toon A. B, BAARTSCHEER, Antonius, OPTHOF, Tobias, WILDERS, Ronald, DE BAKKER, Jacques M. T, CORONEL, Ruben

“…Patients with heart failure (HF) have an increased QRS duration, usually attributed to decreased conduction velocity (CV) due to ionic remodeling but which may…”
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Ionic remodeling of sinoatrial node cells by heart failure by Verkerk, Arie O, Wilders, Ronald, Coronel, Ruben, Ravesloot, Jan H, Verheijck, E Etienne

“…In animal models of heart failure (HF), heart rate decreases as the result of an increase in intrinsic cycle length of the sinoatrial node (SAN). In this…”
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HERG Channel (Dys)function Revealed by Dynamic Action Potential Clamp Technique by Berecki, Géza, Zegers, Jan G., Verkerk, Arie O., Bhuiyan, Zahurul A., de Jonge, Berend, Veldkamp, Marieke W., Wilders, Ronald, van Ginneken, Antoni C.G.

“…The human ether-a-go-go-related gene (HERG) encodes the rapid component of the cardiac delayed rectifier potassium current ( I Kr). Per-Arnt-Sim domain…”
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Role of sequence variations in the human ether -a -go -go -related gene (HERG, KCNH2) in the brugada syndrome by VERKERK, Arie O, WILDERS, Ronald, MANNENS, Marcel M. A. M, TAN, Hanno L, WILDE, Arthur A. M, BEZZINA, Connie R, SCHULZE-BAHR, Eric, BEEKMAN, Leander, BHUIYAN, Zahurul A, BERTRAND, Jessica, ECKARDT, Lars, DONGXIN LIN, BORGGREFE, Martin, BREITHARDT, Günter

“…Brugada syndrome (BrS) is an inherited electrical disorder associated with a high incidence of sudden death. In a minority of patients, it has been linked to…”
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Conduction slowing by the gap junctional uncoupler carbenoxolone by DE GROOT, Joris R, VEENSTRA, Thijs, VERHEIJCK, E. Etienne, VERKERK, Arie O, WILDERS, Ronald, SMITS, Jeroen P. P, WILMS-SCHOPMAN, Francien J. G, WIEGERINCK, Rob F, BOURIER, Jan, BELTERMAN, Charly N. W, CORONEL, Ruben

“…Cellular electrical coupling is essential for normal propagation of the cardiac action potential, whereas reduced electrical coupling is associated with…”
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Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique by Berecki, Géza, Zegers, Jan G., Bhuiyan, Zahurul A., Verkerk, Arie O., Wilders, Ronald, Van Ginneken, Antoni C. G.

“…Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene ( SCN5A ) mutations. In this study, we used the ‘dynamic action potential clamp’ (dAPC)…”
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Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts by VERKERK, Arie O, VELDKAMP, Marieke W, BAARTSCHEER, Antonius, SCHUMACHER, Cees A, KLÖPPING, Corinne, VAN GINNEKEN, Antoni C. G, RAVESLOOT, Jan H

“…Animal studies have shown that the Ca(2+)-activated Cl(-) current (I(Cl(Ca))) and the Na(+)/Ca(2+) exchange current (I(Na/Ca)) contribute to the transient…”
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