Search Results - "Verkerk, A.O."

THE SCN5A1795INSD/+ MUTATION RESULTS IN INCREASED INTRACELLULAR CALCIUM CONCENTRATIONS IN HUMAN CARDIOMYOCYTES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS by Hoekstra, M, Mengarelli, I, Freund, C, Baartscheer, A, Remme, C.A, Mummery, C.L, Wilde, A.A.M, Bezzina, C.R, Verkerk, A.O

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HEY2 , A NOVEL SUSCEPTIBILITY GENE FOR BRUGADA SYNDROME, CONTROLS DEPOLARIZATION AND REPOLARIZATION GRADIENTS IN THE RVOT AND ACROSS THE VENTRICULAR WALL by Podliesna, S, Verkerk, A.O, Wolswinkel, R, Beekman, L, Barc, J, Gessler, M, Christoffels, V.M, Wilde, A.A, Remme, C.A, Bezzina, C.R

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Read-through of SCN5A Nonsense Mutations with the Chemical Compound PTC124 by Koopmann, T.T, Verkerk, A.O, Rook, M, v.d. Heyden, M.A.G, Bezzina, C.R, de Bakker, J.M.T, Wilde, A.A.M

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Membrin/GOSR2 is a novel NaV1.5-interacting protein modulating cardiac conduction by Offerhaus, J, Podliesna, S, Verkerk, A.O, Marchal, G, Lodder, L.E, Boukens, B.J.B, Remme, C.A, Bezzina, C.R

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2014-A-44-CES - THE SCN5A1795INSD/+ MUTATION RESULTS IN INCREASED INTRACELLULAR CALCIUM CONCENTRATIONS IN HUMAN CARDIOMYOCYTES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS by Hoekstra, M., Mengarelli, I., Freund, C., Baartscheer, A., Remme, C.A., Mummery, C.L., Wilde, A.A.M., Bezzina, C.R., Verkerk, A.O.

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2014-A-31-CES - HEY2, A NOVEL SUSCEPTIBILITY GENE FOR BRUGADA SYNDROME, CONTROLS DEPOLARIZATION AND REPOLARIZATION GRADIENTS IN THE RVOT AND ACROSS THE VENTRICULAR WALL by Podliesna, S., Verkerk, A.O., Wolswinkel, R., Beekman, L., Barc, J., Gessler, M., Christoffels, V.M., Wilde, A.A., Remme, C.A., Bezzina, C.R.

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Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials by VERKERK, Arie O, VAN GINNEKEN, Antoni C. G, FIOLET, Jan W. T, ZOCK, Peter L, CORONEL, Ruben, BERECKI, Géza, DEN RUIJTER, Hester M, SCHUMACHER, Cees A, VELDKAMP, Marieke W, BAARTSCHEER, Antonius, CASINI, Simona, OPTHOF, Tobias, HOVENIER, Robert

“…Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil reduce the risk of sudden death presumably by preventing life-threatening arrhythmias. Acutely…”
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Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts by Veldkamp, M.W, Verkerk, A.O, van Ginneken, A.C.G, Baartscheer, A, Schumacher, C, de Jonge, N, de Bakker, J.M.T, Opthof, T

“…Aims Congestive heart failure is characterized by high levels of norepinephrine which is considered to be arrhythmogenic. It is unclear whether increased…”
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Gender disparities in torsade de pointes ventricular tachycardia by Verkerk, A O, Wilders, R, Tan, H L

“…Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this…”
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Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome by Amin, A S, Klemens, C A, Verkerk, A O, Meregalli, P G, Asghari-Roodsari, A, de Bakker, J M T, January, C T, Wilde, A A M, Tan, H L

“…The risk for lethal ventricular arrhythmias is increased in individuals who carry mutations in genes that encode cardiac ion channels. Loss-of-function…”
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Limited role of Ca2+-activated Cl- current in early afterdepolarisations by Verkerk, A O, Tan, H L, Baartscheer, T, Ravesloot, J H

“…OBJECTIVESThe proarrhythmic, early afterdepolarisations during phase two of the action potential (phase-2 EADs) are associated with secondary Ca2+ release from…”
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Cl - current blockade reduces triggered activity based on delayed afterdepolarisations by Verkerk, A O, Veldkamp, M W, van Ginneken, A C G

“…Increasing evidence suggests that a Ca -activated Cl current (I ) contributes to the transient inward current (I ), the current responsible for proarrhythmic…”
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Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation by Remme, C A, Verkerk, A O, Wilde, A A M, Veldkamp, M W, de Bakker, J M T, Bezzina, C R

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Single Cells Isolated from Human Sinoatrial Node: Action Potentials and Numerical Reconstruction of Pacemaker Current by Verkerk, A.O., van Borren, M.M.G., Peters, R.J.G., Broekhuis, E., Lam, K.Y., Coronel, R., de Bakker, J.M.T., Tan, H.L., Wilders, R.

“…Pacemaker activity of the sinoatrial node has extensively been studied in laboratory animals of various species, but is virtually unexplored in man. Most…”
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Gender differences in cardiac electrophysiology by Verkerk, A.O., Wilders, R., Tan, H.L.

“…Gender differences in electrocardiographic (ECG) variables and incidence of cardiac arrhythmias exist. Females have longer rate-corrected QT (QTc) intervals…”
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Computational Model of Rabbit SA Node Pacemaker Activity Probed with Action Potential and Calcium Transient Clamp by van Borren, M.M.G., Zegers, J.G., Verkerk, A.O., Wilders, R.

“…In the past decades, various computational models of the pacemaker activity of single sinoatrial (SA) nodal cells have been developed, building on data…”
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Action potential transfer at the Purkinje-ventricular junction: role of transitional cells by Verkerk, A.O., Veldkamp, M.W., van Ginneken, A.C.G., Wilders, R.

“…At the Purkinje (P) - ventricular (V) junction a zone of "transitional (T)" cells is found. In the present study we investigated the role of these T cells in…”
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Electrical interactions between cardiac cells: what can we learn from two-cell systems? by Wilders, R., Verkerk, A.O., Verheijck, E.E., Kumar, R., Wagner, M.B., Wang, Y., Joyner, R.W.

“…With the ability to enzymatically isolate single cardiac cells from mammalian hearts, the research in cardiac electrophysiology has become focused on the study…”
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Model clamp: a computer tool to probe action potential transfer between cardiac cells by Wilders, R., Verkerk, A.O., Verheijck, E.E., van Ginneken, A.C.G., Kumar, R., Wagner, M.B., Golod, D.A., Goolsby, W.N., Joyner, R.W., Jongsma, H.

“…In the early nineties, Joyner and coworkers introduced the "coupling clamp" technique in which an isolated cardiac cell can be electrically coupled to either…”
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