Search Results - "Verkade, Jorge"

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N‑Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates by van Geel, Remon, Wijdeven, Marloes A, Heesbeen, Ryan, Verkade, Jorge M. M, Wasiel, Anna A, van Berkel, Sander S, van Delft, Floris L

“…A robust, generally applicable, nongenetic technology is presented to convert monoclonal antibodies into stable and homogeneous ADCs. Starting from a native…”
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Organocatalysed asymmetric Mannich reactions by Verkade, Jorge M M, van Hemert, Lieke J C, Quaedflieg, Peter J L M, Rutjes, Floris P J T

“…The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years,…”
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Process Development for the Enzymatic Gram‐Scale Production of the Unnatural Nucleotide Sugar UDP‐6‐Azido‐GalNAc by Frohnmeyer, Hannes, Verkade, Jorge M. M., Spiertz, Markus, Rentsch, Andreas, Hoffmann, Niels, Sobota, Milan, Schwede, Frank, Tjeerdsma, Peter, Elling, Lothar

“…Azido sugars hold great promise as substrates in numerous click‐chemistry applications. However, the synthesis of activated azido sugars is limited by cost and…”
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Genetic Encoding of a Bicyclo[6.1.0]nonyne-Charged Amino Acid Enables Fast Cellular Protein Imaging by Metal-Free Ligation by Borrmann, Annika, Milles, Sigrid, Plass, Tilman, Dommerholt, Jan, Verkade, Jorge M. M., Wießler, Manfred, Schultz, Carsten, van Hest, Jan C. M., van Delft, Floris L., Lemke, Edward A.

“…Visualizing biomolecules by fluorescent tagging is a powerful method for studying their behaviour and function inside cells. We prepared and genetically…”
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Enzymatic glycan remodeling-metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering by Wijdeven, Marloes A., van Geel, Remon, Hoogenboom, Jorin H., Verkade, Jorge M. M., Janssen, Brian M. G., Hurkmans, Inge, de Bever, Laureen, van Berkel, Sander S., van Delft, Floris L.

“…Antibody-drug conjugates (ADCs) are increasingly powerful medicines for targeted cancer therapy. Inspired by the trend to further improve their therapeutic…”
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Emergence of single-molecular chirality from achiral reactants by Steendam, René R. E., Verkade, Jorge M. M., van Benthem, Tim J. B., Meekes, Hugo, van Enckevort, Willem J. P., Raap, Jan, Rutjes, Floris P. J. T., Vlieg, Elias

“…The synthesis of enantiopure molecules from achiral precursors without the need for pre-existing chirality is a major challenge associated with the origin of…”
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Enantio- and diastereoselective synthesis of γ-amino alcohols by Verkade, Jorge M M, Quaedflieg, Peter J L M, Verzijl, Gerard K M, Lefort, Laurent, van Delft, Floris L, de Vries, Johannes G, Rutjes, Floris P J T

“…The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods…”
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Oligonucleotide tagging for copper-free click conjugation by Jawalekar, Anup M, Malik, Sudip, Verkade, Jorge M M, Gibson, Brian, Barta, Nancy S, Hodges, John C, Rowan, Alan, van Delft, Floris L

“…Copper-free click chemistry between cyclooctynes and azide is a mild, fast and selective technology for conjugation of oligonucleotides. However, technology…”
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A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates by Verkade, Jorge, Wijdeven, Marloes, Van Geel, Remon, Janssen, Brian, Van Berkel, Sander, Van Delft, Floris

“…Despite tremendous efforts in the field of targeted cancer therapy with antibody–drug conjugates (ADCs), attrition rates have been high. Historically, the…”
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An Enantioselective Organocatalytic Approach to Both Enantiomers of Lasubine II by Verkade, Jorge M. M, van der Pijl, Ferdi, Willems, Marian M. J. H. P, Quaedflieg, Peter J. L. M, van Delft, Floris L, Rutjes, Floris P. J. T

“…A concise stereoselective route providing access to both enantiomers of the bioactive quinolizidine alkaloid lasubine II has been developed. The…”
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Mild and efficient deprotection of the amine protecting p-methoxyphenyl (PMP) group by Verkade, Jorge M.M., van Hemert, Lieke J.C., Quaedflieg, Peter J.L.M., Alsters, Paul L., van Delft, Floris L., Rutjes, Floris P.J.T.

“…Efficient and scalable oxidative cleavage procedures for the amine protecting p-methoxyphenyl (PMP) group are described. Mild and efficient procedures for…”
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Laccase-Mediated Deprotection of para-Methoxyphenyl (PMP)-Protected Amines by Verkade, Jorge M. M., van Hemert, Lieke J. C., Quaedflieg, Peter J. L. M., Schoemaker, Hans E., Schürmann, Martin, van Delft, Floris L., Rutjes, Floris P. J. T.

“…A novel enzymatic procedure for the oxidative deprotection of p‐methoxyphenyl (PMP)‐protected amines is described. By using laccases (E.C. 1.10.3.2) under…”
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Correction: Verkade, J.M.M.; et al. A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates. Antibodies 2018, 7, 12 by Verkade, Jorge, Wijdeven, Marloes, van Geel, Remon, Janssen, Brian, van Berkel, Sander, van Delft, Floris

“…The conflict of interest section of the published paper [1] has been updated as follows[...]…”
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Optimizing the Deprotection of the Amine Protecting p-Methoxyphenyl Group in an Automated Microreactor Platform by Koch, Kaspar, van Weerdenburg, Bram J. A, Verkade, Jorge M. M, Nieuwland, Pieter J, Rutjes, Floris P. J. T, van Hest, Jan C. M

“…Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization…”
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A Novel Purification Method in Organic Synthesis Using Hydrogen Bonding by Gruijters, Bas W. T., Verkade, Jorge M. M., van Delft, Floris L., Sijbesma, Rint P., Hermkens, Pedro H. H., Rutjes, Floris P. J. T.

“…A new workup and purification method based on quadruple hydrogen‐bonding interactions is reported. Substrates containing a hydrogen‐bonding affinity tag –…”
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Abstract 3815: Decomposition of parameters contributing to the improved therapeutic index of ADCs obtained by GlycoConnect™ and HydraSpace™ Technologies by Delft, Floris van, Janssen, Brian, Geel, Remon van, Wijdeven, Marloes, Verkade, Jorge, Berkel, Sander van

“…We have found that conjugation of toxic payloads to the native glycan of a monoclonal antibody by chemoenzymatic remodeling (GlycoConnect™ technology)…”
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