Search Results - "Verhoye, Lieven"

Griffithsin Has Antiviral Activity against Hepatitis C Virus by MEULEMAN, Philip, ALBECKA, Anna, BELOUZARD, Sandrine, VERCAUTEREN, Koen, VERHOYE, Lieven, WYCHOWSKI, Czeslaw, LEROUX-ROELS, Geert, PALMER, Kenneth E, DUBUISSON, Jean

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Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes by Michailidis, Eleftherios, Vercauteren, Koen, Mancio-Silva, Liliana, Andrus, Linda, Jahan, Cyprien, Ricardo-Lax, Inna, Zou, Chenhui, Kabbani, Mohammad, Park, Paul, Quirk, Corrine, Pyrgaki, Christina, Razooky, Brandon, Verhoye, Lieven, Zoluthkin, Irene, Lu, Wei-Yu, Forbes, Stuart J., Chiriboga, Luis, Theise, Neil D., Herzog, Roland W., Suemizu, Hiroshi, Schneider, William M., Shlomai, Amir, Meuleman, Philip, Bhatia, Sangeeta N., Rice, Charles M., de Jong, Ype P.

“…Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan…”
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A Human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo by Meuleman, Philip, Catanese, Maria Teresa, Verhoye, Lieven, Desombere, Isabelle, Farhoudi, Ali, Jones, Christopher T., Sheahan, Timothy, Grzyb, Katarzyna, Cortese, Riccardo, Rice, Charles M., Leroux-Roels, Geert, Nicosia, Alfredo

“…Endstage liver disease caused by chronic hepatitis C virus (HCV) infection is the leading indication for liver transplantation in the Western world. However,…”
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Blocking Entry of Hepatitis B and D Viruses to Hepatocytes as a Novel Immunotherapy for Treating Chronic Infections by Maravelia, Panagiota, Frelin, Lars, Ni, Yi, Caro Pérez, Noelia, Ahlén, Gustaf, Jagya, Neetu, Verch, Georg, Verhoye, Lieven, Pater, Lena, Johansson, Magnus, Pasetto, Anna, Meuleman, Philip, Urban, Stephan, Sällberg, Matti

“…Abstract Background Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long…”
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Study of Hepatitis E Virus-4 Infection in Human Liver-Chimeric, Immunodeficient, and Immunocompetent Mice by Collignon, Laura, Verhoye, Lieven, Hakze-Van der Honing, Renate, Van der Poel, Wim H M, Meuleman, Philip

“…The hepatitis E virus (HEV) is responsible for 20 million infections worldwide per year. Although, HEV infection is mostly self-limiting, immunocompromised…”
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A Role for B Cells to Transmit Hepatitis C Virus Infection by Desombere, Isabelle, Van Houtte, Freya, Farhoudi, Ali, Verhoye, Lieven, Buysschaert, Caroline, Gijbels, Yvonne, Couvent, Sibyl, Swinnen, Wilfried, Van Vlierberghe, Hans, Elewaut, André, Magri, Andrea, Stamataki, Zania, Meuleman, Philip, McKeating, Jane A, Leroux-Roels, Geert

“…Hepatitis C virus (HCV) is highly variable and transmits through infected blood to establish a chronic liver infection in the majority of patients. Our…”
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A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo by Desombere, Isabelle, Mesalam, Ahmed Atef, Urbanowicz, Richard A., Van Houtte, Freya, Verhoye, Lieven, Keck, Zhen-Yong, Farhoudi, Ali, Vercauteren, Koen, Weening, Karin E., Baumert, Thomas F., Patel, Arvind H., Foung, Steven K.H., Ball, Jonathan, Leroux-Roels, Geert, Meuleman, Philip

“…Infections with hepatitis C virus (HCV) represent a worldwide health burden and a prophylactic vaccine is still not available. Liver transplantation (LT) is…”
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A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection by Burm, Rani, Van Houtte, Freya, Verhoye, Lieven, Mesalam, Ahmed Atef, Ciesek, Sandra, Roingeard, Philippe, Wedemeyer, Heiner, Leroux-Roels, Geert, Meuleman, Philip

“…Elimination of chronic HBV/HDV infection remains a major global health challenge. Targeting excessive hepatitis B surface antigen (HBsAg) release may provide…”
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Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems by Burkard, Thomas, Proske, Nora, Resner, Kathrin, Collignon, Laura, Knegendorf, Leonard, Friesland, Martina, Verhoye, Lieven, Sayed, Ibrahim M, Brüggemann, Yannick, Nocke, Maximilian K, Behrendt, Patrick, Wedemeyer, Heiner, Meuleman, Philip, Todt, Daniel, Steinmann, Eike

“…Hepatitis C virus (HCV) constitutes a global health problem, while hepatitis E virus (HEV) is the major cause of acute viral hepatitis globally. HCV/HEV…”
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Inflammation Alters the Secretome and Immunomodulatory Properties of Human Skin-Derived Precursor Cells by De Kock, Joery, Rodrigues, Robim Marcelino, Branson, Steven, Verhoye, Lieven, Colemonts-Vroninks, Haaike, Rombaut, Matthias, Boeckmans, Joost, Neuckermans, Jessie, Lequeue, Sien, Buyl, Karolien, Merimi, Makram, Moussa Agha, Douaa, De Boe, Veerle, Lagneaux, Laurence, Meuleman, Philip, Vanhaecke, Tamara, Najar, Mehdi

“…Human skin-derived precursors (SKP) represent a group of somatic stem/precursor cells that reside in dermal skin throughout life that harbor clinical…”
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Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver by Sayed, Ibrahim M, Verhoye, Lieven, Cocquerel, Laurence, Abravanel, Florence, Foquet, Lander, Montpellier, Claire, Debing, Yannick, Farhoudi, Ali, Wychowski, Czeslaw, Dubuisson, Jean, Leroux-Roels, Geert, Neyts, Johan, Izopet, Jacques, Michiels, Thomas, Meuleman, Philip

“…The hepatitis E virus (HEV) is responsible for approximately 20 million infections per year worldwide. Although most infected people can spontaneously clear an…”
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Robust hepatitis E virus infection and transcriptional response in human hepatocytes by Todt, Daniel, Friesland, Martina, Moeller, Nora, Praditya, Dimas, Kinast, Volker, Brüggemann, Yannick, Knegendorf, Leonard, Burkard, Thomas, Steinmann, Joerg, Burm, Rani, Verhoye, Lieven, Wahid, Avista, Meister, Toni Luise, Engelmann, Michael, Pfankuche, Vanessa M., Puff, Christina, Vondran, Florian W. R., Baumgärtner, Wolfgang, Meuleman, Philip, Behrendt, Patrick, Steinmann, Eike

“…Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and the leading cause for acute viral hepatitis worldwide. The virus is classified as a…”
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The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo by Todt, Daniel, Moeller, Nora, Praditya, Dimas, Kinast, Volker, Friesland, Martina, Engelmann, Michael, Verhoye, Lieven, Sayed, Ibrahim M., Behrendt, Patrick, Dao Thi, Viet Loan, Meuleman, Philip, Steinmann, Eike

“…Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and a member of the genus Orthohepevirus in the family Hepeviridae. HEV infections are…”
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Hepatitis E Virus (HEV) Open Reading Frame 2 Antigen Kinetics in Human-Liver Chimeric Mice and Its Impact on HEV Diagnosis by Sayed, Ibrahim M, Verhoye, Lieven, Montpellier, Claire, Abravanel, Florence, Izopet, Jacques, Cocquerel, Laurence, Meuleman, Philip

“…Hepatitis E virus infection (HEV) is an emerging problem in developed countries. Diagnosis of HEV infection is based on the detection of HEV-specific…”
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Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma by Sayed, Ibrahim M., Foquet, Lander, Verhoye, Lieven, Abravanel, Florence, Farhoudi, Ali, Leroux-Roels, Geert, Izopet, Jacques, Meuleman, Philip

“…Hepatitis E virus (HEV) is considered as an important pathogen in developing countries but there is growing evidence of its increasing significance and…”
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HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice by Prentoe, Jannick, Verhoye, Lieven, Velázquez Moctezuma, Rodrigo, Buysschaert, Caroline, Farhoudi, Ali, Wang, Richard, Alter, Harvey, Meuleman, Philip, Bukh, Jens

“…HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We…”
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JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in evaluation of virus neutralization by Collignon, Laura, Holmbeck, Kenn, Just, Ashley, Verhoye, Lieven, Velázquez-Moctezuma, Rodrigo, Fahnøe, Ulrik, Carlsen, Thomas H R, Law, Mansun, Prentoe, Jannick, Scheel, Troels K H, Gottwein, Judith M, Meuleman, Philip, Bukh, Jens

“…HCV infection continues to be a major global health burden, despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the…”
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Reduced hepatic bile acid uptake and blocked hepatitis B viral infection after oral administration of novel small molecule inhibitors of the sodium taurocholate co-transporting polypeptide (NTCP) by Pervolaraki, Kalliopi, Vanherck, Jean-Christophe, Marcadet, Charlène, Verhoye, Lieven, De Meyer, Amse, Rasulova, Madina, Lyoo, Heyrhyoung, Paulissen, Jasmine, Thibaut, Hendrik Jan, De Vos, Kristof, Chaltin, Patrick, Neyts, Johan, Annaert, Pieter, Meuleman, Philip, Marchand, Arnaud, Versele, Matthias, van de Graaf, Stan

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FRI-231 - Reduced hepatic bile acid uptake and blocked hepatitis B viral infection after oral administration of novel small molecule inhibitors of the sodium taurocholate co-transporting polypeptide (NTCP) by Pervolaraki, Kalliopi, Vanherck, Jean-Christophe, Marcadet, Charlène, Verhoye, Lieven, De Meyer, Amse, Rasulova, Madina, Lyoo, Heyrhyoung, Paulissen, Jasmine, Thibaut, Hendrik Jan, De Vos, Kristof, Chaltin, Patrick, Neyts, Johan, Annaert, Pieter, Meuleman, Philip, Marchand, Arnaud, Versele, Matthias, van de Graaf, Stan

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A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function by Meister, Toni Luise, Brüggemann, Yannick, Nocke, Maximilian K, Ulrich, Rainer G, Schuhenn, Jonas, Sutter, Kathrin, Gömer, André, Bader, Verian, Winklhofer, Konstanze F, Broering, Ruth, Verhoye, Lieven, Meuleman, Philip, Vondran, Florian W R, Camuzet, Charline, Cocquerel, Laurence, Todt, Daniel, Steinmann, Eike

“…Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically transmitted viral hepatitis worldwide…”
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