Search Results - "Verhoef, J. Coos"

Preparation of coated nanoparticles for a new mucosal vaccine delivery system by Borges, Olga, Borchard, Gerrit, Verhoef, J. Coos, de Sousa, Adriano, Junginger, Hans E.

“…It has been found that the adsorption of antigens onto chitosan particles is an easy and unique mild loading process suitable to be used with vaccines. In…”
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N -Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model by Amidi, Maryam, Romeijn, Stefan G, Verhoef, J. Coos, Junginger, Hans E, Bungener, Laura, Huckriede, Anke, Crommelin, Daan J.A, Jiskoot, Wim

“…Abstract In this study, the potential of N -trimethyl chitosan (TMC) nanoparticles as a carrier system for the nasal delivery of a monovalent influenza subunit…”
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Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice by van der Lubben, Inez M., Kersten, Gideon, Fretz, Marjan M., Beuvery, Coen, Coos Verhoef, J., Junginger, Hans E.

“…In this study, the ability of chitosan microparticles to enhance both the systemic and local immune responses against diphtheria toxoid (DT) after oral and…”
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Nasal mucociliary clearance as a factor in nasal drug delivery by Marttin, Emmeline, Schipper, Nicolaas G.M, Verhoef, J.Coos, Merkus, Frans W.H.M

“…The nasal mucociliary clearance system transports the mucus layer that covers the nasal epithelium towards the nasopharynx by ciliary beating. Its function is…”
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Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2) by Kotzé, Awie F, Lueßen, Henrik L, de Leeuw, Bas J, de Boer, (A)Bert G, Coos Verhoef, J, Junginger, Hans E

“…A partially quaternized chitosan derivative, N-trimethyl chitosan chloride (TMC) (degree of quaternization 12.28%), was synthesized and the effects of this…”
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Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin, octreotide and insulin by Dorkoosh, Farid A., Coos Verhoef, J., Ambagts, Matheus H.C., Rafiee-Tehrani, Morteza, Borchard, Gerrit, Junginger, Hans E.

“…Novel peroral peptide drug delivery systems based on superporous hydrogel (SPH) and SPH composite (SPHC) have recently been developed in our laboratory. In…”
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Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers by Dorkoosh, Farid A, Broekhuizen, Corine A N, Borchard, Gerrit, Rafiee-Tehrani, Morteza, Verhoef, J Coos, Junginger, Hans E

“…The purpose of this study was to investigate the mechanism of opening of tight junctions in Caco-2 cell monolayers using superporous hydrogel (SPH) and SPH…”
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Modulation of Immune Response to Group C Meningococcal Conjugate Vaccine Given Intranasally to Mice Together with the LTK63 Mucosal Adjuvant and the Trimethyl Chitosan Delivery System by Baudner, Barbara C., Morandi, Maurizio, Giuliani, Marzia M., Verhoef, J. Coos, Junginger, Hans E., Costantino, Paolo, Rappuoli, Rino, Del Giudice, Giuseppe

“…Previous work had shown that the immunogenicity of conjugate vaccine against group C meningococci (CRM-MenC) is enhanced when it is delivered intranasally…”
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The nasal mucociliary clearance : relevance to nasal drug delivery by SHIPPER, N. G. M, COOS VERHOEF, J, MERKUS, F. W. H. M

“…Mucociliary clearance is an important physiological defense mechanism of the respiratory tract to protect the body against noxious inhaled materials. This…”
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Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats : Effects of absorption enhancers by MARTTIN, E, COOS VERHOEF, J, CULLANDER, C, ROMEIJN, S. G, NAGELKERKE, J. F, MERKUS, F. W. H. M

“…To visualize the transport pathway(s) of high molecular weight model compounds across rat nasal epithelium in vivo using confocal laser scanning microscopy…”
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The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines by Baudner, Barbara C, Giuliani, Marzia M, Verhoef, J.Coos, Rappuoli, Rino, Junginger, Hans E, Giudice, Giuseppe Del

“…In this paper we evaluated chitosan microparticles as a vaccine delivery system as well as the mucosal adjuvant LTK63, a nontoxic Escherichia coli enterotoxin…”
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In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels by Polnok, Assadang, Verhoef, J.Coos, Borchard, Gerrit, Sarisuta, Narong, Junginger, Hans E.

“…The aim of this study was to investigate and modify the potential of drug-delivery systems based on superporous hydrogel (SPH) for improving the intestinal…”
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Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat by Lehr, C M, Bouwstra, J A, Kok, W, De Boer, A G, Tukker, J J, Verhoef, J C, Breimer, D D, Junginger, H E

“…The absorption across rat intestinal tissue of the model peptide drug 9-desglycinamide, 8-arginine vasopressin from bioadhesive formulations was studied…”
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Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study by van den Berg, Mascha P, Merkus, Paul, Romeijn, Stefan G, Verhoef, J Coos, Merkus, Frans W H M

“…To investigate the possibility of direct transport of melatonin from the nasal cavity into the cerebrospinal fluid (CSF) after nasal administration in rats and…”
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Uptake of estradiol or progesterone into the CSF following intranasal and intravenous delivery in rats by van den Berg, Mascha P, Verhoef, J.Coos, Romeijn, Stefan G, Merkus, Frans W.H.M

“…The uptake of estradiol and progesterone into the cerebrospinal fluid (CSF) after intranasal and intravenous administration in rats was investigated. Each…”
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N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces : In vitro evaluation in intestinal epithelial cells (Caco-2) by KOTZE, A. F, LUESSEN, H. L, DE LEEUW, B. J, DE BOER, A. B. G, VERHOEF, J. C, JUNGINGER, H. E

“…Previous studies have established that chitosan hydrochloride and glutamate are potent absorption enhancers for large hydrophilic compounds across mucosal…”
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Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity by van den Berg, Mascha P, Romeijn, Stefan G, Verhoef, J.Coos, Merkus, Frans W.H.M

“…Drug transport from the nasal cavity to the brain has gained much interest in the last decade. In the present study, a model was developed to determine the…”
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Intestinal absorption of octreotide using trimethyl chitosan chloride: Studies in pigs by THANOU, Maya, VERHOEF, J. Coos, VERHEIJDEN, Jos H. M, JUNGINGER, Hans E

“…To investigate the enhancing effect of trimethyl chitosan chloride (TMC) on the enteral absorption of octreotide and to delineate the required doses of both…”
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Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform by Baudner, Barbara C., Verhoef, J. Coos, Giuliani, Marzia M., Peppoloni, Samuele, Rappuoli, Rino, Giudice, Giuseppe Del, Junginger, Hans E.

“…Chitosan and its derivative N-trimethyl chitosan chloride (TMC), given as microparticles or powder suspensions, and the non-toxic mucosal adjuvant LTK63, were…”
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Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers by DORKOOSH, Farid A, VERHOEF, J. Coos, VERHEIJDEN, Jos H. M, RAFIEE-TEHRANI, Morteza, BORCHARD, Gerrit, JUNGINGER, Hans E

“…The aim of this study was to investigate the enhancement of peroral octreotide absorption using delivery systems based on superporous hydrogel (SPH) and SPH…”
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