Search Results - "Verheyen, Fons K."

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels by BOSMA, Madeleen, HESSELINK, Matthijs K. C, KERSTEN, Sander, SCHRAUWEN, Patrick, SPARKS, Lauren M, TIMMERS, Silvie, FERRAZ, Maria Joao, MATTIJSSEN, Frits, BEURDEN, Denis Van, SCHAART, Gert, DE BAETS, Marc H, VERHEYEN, Fons K

“…Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and…”
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Folic acid reduces doxorubicin‐induced cardiomyopathy by modulating endothelial nitric oxide synthase by Octavia, Yanti, Kararigas, Georgios, Boer, Martine, Chrifi, Ihsan, Kietadisorn, Rinrada, Swinnen, Melissa, Duimel, Hans, Verheyen, Fons K., Brandt, Maarten M., Fliegner, Daniela, Cheng, Caroline, Janssens, Stefan, Duncker, Dirk J., Moens, An L.

“…The use of doxorubicin (DOXO) as a chemotherapeutic drug has been hampered by cardiotoxicity leading to cardiomyopathy and heart failure. Folic acid (FA) is a…”
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Absence of thrombospondin-2 causes age-related dilated cardiomyopathy by Swinnen, Melissa, Vanhoutte, Davy, Van Almen, Geert C, Hamdani, Nazha, Schellings, Mark W M, D'hooge, Jan, Van der Velden, Jolanda, Weaver, Matthew S, Sage, E Helene, Bornstein, Paul, Verheyen, Fons K, VandenDriessche, Thierry, Chuah, Marinee K, Westermann, Dirk, Paulus, Walter J, Van de Werf, Frans, Schroen, Blanche, Carmeliet, Peter, Pinto, Yigal M, Heymans, Stephane

“…The progressive shift from a young to an aged heart is characterized by alterations in the cardiac matrix. The present study investigated whether the…”
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Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy by van Almen, Geert C, Swinnen, Melissa, Carai, Paolo, Verhesen, Wouter, Cleutjens, Jack P.M, D'hooge, Jan, Verheyen, Fons K, Pinto, Yigal M, Schroen, Blanche, Carmeliet, Peter, Heymans, Stephane

“…Abstract Clinical use of the antineoplastic agent doxorubicin (DOX) is limited by its cardiomyocyte toxicity. Attempts to decrease cardiomyocyte injury showed…”
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Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis by Segers, Filip M E, Ruder, Adele V, Westra, Marijke M, Lammers, Twan, Dadfar, Seyed Mohammadali, Roemhild, Karolin, Lam, Tin Sing, Kooi, Marianne Eline, Cleutjens, Kitty B J M, Verheyen, Fons K, Schurink, Geert W H, Haenen, Guido R, van Berkel, Theo J C, Bot, Ilze, Halvorsen, Bente, Sluimer, Judith C, Biessen, Erik A L

“…(Ultra) Small superparamagnetic iron oxide nanoparticles, (U)SPIO, are widely used as magnetic resonance imaging contrast media and assumed to be safe for…”
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Osteoglycin Prevents Cardiac Dilatation and Dysfunction After Myocardial Infarction Through Infarct Collagen Strengthening by Van Aelst, Lucas N.L, Voss, Sandra, Carai, Paolo, Van Leeuwen, Rick, Vanhoutte, Davy, Sanders-van Wijk, Sandra, Eurlings, Luc, Swinnen, Melissa, Verheyen, Fons K, Verbeken, Eric, Nef, Holger, Troidl, Christian, Cook, Stuart A, Brunner-La Rocca, Hans-Peter, Möllmann, Helge, Papageorgiou, Anna-Pia, Heymans, Stephane

“…RATIONALE:To maintain cardiac mechanical and structural integrity after an ischemic insult, profound alterations occur within the extracellular matrix…”
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Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon by Grootjans, Joep, Hundscheid, Inca H R, Lenaerts, Kaatje, Boonen, Bas, Renes, Ingrid B, Verheyen, Fons K, Dejong, Cornelis H, von Meyenfeldt, Maarten F, Beets, Geerard L, Buurman, Wim A

“…Colonic ischaemia is frequently observed in clinical practice. This study provides a novel insight into the pathophysiology of colon ischaemia/reperfusion (IR)…”
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Starvation Compromises Paneth Cells by Hodin, Caroline M, Lenaerts, Kaatje, Grootjans, Joep, de Haan, Jacco J, Hadfoune, M'hamed, Verheyen, Fons K, Kiyama, Hiroshi, Heineman, Erik, Buurman, Wim A

“…Lack of enteral feeding, with or without parenteral nutritional support, is associated with increased intestinal permeability and translocation of bacteria…”
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Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion by Grootjans, Joep, Hodin, Caroline M, de Haan, Jacco–Juri, Derikx, Joep P.M, Rouschop, Kasper M.A, Verheyen, Fons K, van Dam, Ronald M, Dejong, Cornelis H.C, Buurman, Wim A, Lenaerts, Kaatje

“…Background & Aims In the intestine, Paneth cells participate in the innate immune response. Their highly secretory function makes them susceptible to…”
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Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals by Hodin, Caroline M, Verdam, Froukje J, Grootjans, Joep, Rensen, Sander S, Verheyen, Fons K, Dejong, Cornelis HC, Buurman, Wim A, Greve, Jan Willem, Lenaerts, Kaatje

“…The intestinal microbiota is increasingly acknowledged to play a crucial role in the development of obesity. A shift in intestinal microbiota composition…”
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Tu1742 Human Small Intestinal Barrier Function and Tight Junction Integrity During Ischemia Reperfusion by Hundscheid, Inca H, Schellekens, Dirk H, Grootjans, Joep, Verheyen, Fons K, van Dam, Ronald, Derikx, Joep, Dejong, Corrnelis H, Lenaerrts, Kaatje

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Re‐expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies by Driesen, Ronald B., Verheyen, Fons K., Debie, Wiel, Blaauw, Erik, Babiker, Fawzi A., Cornelussen, Richard N.M., Ausma, Jannie, Lenders, Marie‐Hélène, Borgers, Marcel, Chaponnier, Christine, Ramaekers, Frans C. S.

“…Differentiation of foetal cardiomyocytes is accompanied by sequential actin isoform expression, i.e. down‐regulation of the ‘embryonic’ alpha smooth muscle…”
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Alveolocapillary model system to study alveolar re-epithelialization by Willems, Coen H.M.P., Zimmermann, Luc J.I., Sanders, Patricia J.L.T., Wagendorp, Margot, Kloosterboer, Nico, Cohen Tervaert, Jan Willem, Duimel, Hans J.Q., Verheyen, Fons K.C.P., van Iwaarden, J.Freek

“…In the present study an in vitro bilayer model system of the pulmonary alveolocapillary barrier was established to investigate the role of the microvascular…”
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Partial cell fusion : A newly recognized type of communication between dedifferentiating cardiomyocytes and fibroblasts by DRIESEN, Ronald B, DISPERSYN, Gerrit D, VERHEYEN, Fons K, VAN DEN EIJNDE, Stefan M, HOFSTRA, Leo, THONE, Fred, DIJKSTRA, Petra, DEBIE, Wiel, BORGERS, Marcel, RAMAEKERS, Frans C. S

“…Fibroblasts have been shown to couple to neonatal cardiomyocytes in heterocellular cultures through functional gap junctions. Our objective was to provide…”
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Structural remodelling of cardiomyocytes in the border zone of infarcted rabbit heart by Driesen, Ronald B, Verheyen, Fons K, Dijkstra, Petra, Thoné, Fred, Cleutjens, Jack P, Lenders, Marie-Hélène, Ramaekers, Frans C. S, Borgers, Marcel

“…Cardiomyocyte dedifferentiation, as detected in hibernating myocardium of chronic ischemic patients, is one of the characteristics seen at the border of…”
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S1792 Effects of Ethanol and Acetaldehyde on Epithelial Integrity in a Three Dimensional (3D) Epithelial Cell Culture Model by Elamin, Elhaseen, Jonkers, Daisy, Troost, Freddy, Juuti-Uusitalo, Kati, van IJzendoorn, Sven C, Duimel, Hans, Broers, Jos L, Verheyen, Fons K, Dekker, Jan, Masclee, Ad

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Structural adaptation in adult rabbit ventricular myocytes: influence of dynamic physical interaction with fibroblasts by Driesen, Ronald B, Verheyen, Fons K, Dispersyn, Gerrit D, Thoné, Fred, Lenders, Marie-Hélène, Ramaekers, Frans C S, Borgers, Marcel

“…The mechanism of induction of cardiomyocyte (CM) dedifferentiation, as seen in chronic hibernating myocardium, is largely unknown. Recently, a cellular model…”
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Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation by Driesen, Ronald B, Verheyen, Fons K, Schaart, Gert, de Mazière, Ann, Viebahn, Christoph, Prinzen, Frits W, Lenders, Marie-Hélène, Debie, Wiel, Totzeck, Andreas, Borgers, Marcel, Ramaekers, Frans C.S

“…Abstract Background Cardiotin expression is observed in adult cardiac tissue. In the present study, we provide evidence for the specific localization of…”
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Abstract 15588: Folic Acid Attenuates Acute Doxorubicin-Induced Cardiomyopathy by Modulating Endothelial Nitric Oxide Synthase and Mitochondrial Integrity by Octavia, Yanti, Kararigas, Georgios, de Boer, Martine, Kietadisorn, Rinrada, Swinnen, Melissa, Duimel, Hans, Verheyen, Fons K, Janssens, Stefan, Duncker, Dirk J, Moens, An L

“…AimsIn the pathogenesis of doxorubicin (DOXO)-induced cardiomyopathy, endothelial nitric oxide synthase (eNOS) has a pivotal role. Here we tested the…”
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Modulating Endothelial Nitric Oxide Synthase by Folic Acid Reduces Doxorubicin-Induced Cardiotoxicity and Mortality by Octavia, Yanti, Swinnen, Melissa, Kararigas, Georgios, Kietadisorn, Rinrada, Fliegner, Daniela, Verheyen, Fons K., Janssens, Stefan P., Regitz-Zagrosek, Vera, Moens, An L.

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