Search Results - "Verheyen, Esther M"

The power of Drosophila in modeling human disease mechanisms by Verheyen, Esther M

“…Six years ago, DMM launched a subject collection called 'Drosophila as a Disease Model'. This collection features Review-type articles and original research…”
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Homeodomain-Interacting Protein Kinase Regulates Yorkie Activity to Promote Tissue Growth by Chen, Joanna, Verheyen, Esther M.

“…The Hippo (Hpo) tumor suppressor pathway regulates tissue size by inhibiting cell proliferation and promoting apoptosis [1–5]. The core components of the…”
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A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model by Wong, Kenneth Kin Lam, Liao, Jenny Zhe, Verheyen, Esther M

“…Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive…”
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Hipk is required for JAK/STAT activity during development and tumorigenesis by Tettweiler, Gritta, Blaquiere, Jessica A, Wray, Nathan B, Verheyen, Esther M

“…Drosophila has been instrumental as a model system in studying signal transduction and revealing molecular functions in development and human diseases. A point…”
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Metabolic reprogramming in cancer: mechanistic insights from Drosophila by Wong, Kenneth Kin Lam, Verheyen, Esther M

“…Cancer cells constantly reprogram their metabolism as the disease progresses. However, our understanding of the metabolic complexity of cancer remains…”
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Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome by Tophkhane, Shruti S, Fu, Katherine, Verheyen, Esther M, Richman, Joy M

“…Robinow syndrome is a rare disease caused by variants of seven WNT pathway genes. Craniofacial features include widening of the nasal bridge and jaw…”
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A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction by Sulkowski, Mikolaj J, Han, Tae Hee, Ott, Carolyn, Wang, Qi, Verheyen, Esther M, Lippincott-Schwartz, Jennifer, Serpe, Mihaela

“…At the Drosophila NMJ, BMP signaling is critical for synapse growth and homeostasis. Signaling by the BMP7 homolog, Gbb, in motor neurons triggers a canonical…”
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The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled by Pradhan-Sundd, Tirthadipa, Verheyen, Esther M

“…Endosomal trafficking of signaling proteins plays an essential role in cellular homeostasis. The seven-pass transmembrane protein Frizzled (Fz) is a critical…”
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Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling by Swarup, Sharan, Verheyen, Esther M

“…Drosophila Homeodomain-interacting protein kinase (Hipk) has been shown to regulate in vivo, the stability of Armadillo, the transcriptional effector of…”
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Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila by Liao, Jenny Zhe, Chung, Hyung-lok, Shih, Claire, Wong, Kenneth Kin Lam, Dutta, Debdeep, Nil, Zelha, Burns, Catherine Grace, Kanca, Oguz, Park, Ye-Jin, Zuo, Zhongyuan, Marcogliese, Paul C., Sew, Katherine, Bellen, Hugo J., Verheyen, Esther M.

“…Cdk8 in Drosophila is the orthologue of vertebrate CDK8 and CDK19 . These proteins have been shown to modulate transcriptional control by RNA polymerase II. We…”
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A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation by Ganguly, Payel, Madonsela, Landiso, Chao, Jesse T, Loewen, Christopher J R, O'Connor, Timothy P, Verheyen, Esther M, Allan, Douglas W

“…Gene variant discovery is becoming routine, but it remains difficult to usefully interpret the functional consequence or disease relevance of most variants. To…”
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Integrins Regulate Apical Constriction via Microtubule Stabilization in the Drosophila Eye Disc Epithelium by Fernandes, Vilaiwan M., McCormack, Kasandra, Lewellyn, Lindsay, Verheyen, Esther M.

“…During morphogenesis, extracellular signals trigger actomyosin contractility in subpopulations of cells to coordinate changes in cell shape. To illuminate the…”
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Mechanistic studies in Drosophila and chicken give new insights into functions of DVL1 in dominant Robinow syndrome by Gignac, Sarah J, MacCharles, Katja R, Fu, Katherine, Bonaparte, Kywana, Akarsu, Gamze, Barrett, Thalia W, Verheyen, Esther M, Richman, Joy M

“…The study of rare genetic diseases provides valuable insights into human gene function. The autosomal dominant or autosomal recessive forms of Robinow syndrome…”
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Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model by Kinsey, Stephen D, Vinluan, Justin P, Shipman, Gerald A, Verheyen, Esther M

“…Abstract Homeodomain-interacting protein kinases (HIPKs) are a family of four conserved proteins essential for vertebrate development, as demonstrated by…”
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Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function by Wang, Simon J H, Sinclair, Donald A R, Kim, Hae-Yoon, Kinsey, Stephen D, Yoo, Byoungjoo, Shih, Claire R Y, Wong, Kenneth K L, Krieger, Charles, Harden, Nicholas, Verheyen, Esther M

“…Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous…”
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The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model by Yu, Kewei, Ramkumar, Niveditha, Wong, Kenneth Kin Lam, Tettweiler, Gritta, Verheyen, Esther M.

“…Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk in Drosophila causes…”
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Homeodomain-interacting protein kinase promotes tumorigenesis and metastatic cell behavior by Blaquiere, Jessica A, Wong, Kenneth Kin Lam, Kinsey, Stephen D, Wu, Jin, Verheyen, Esther M

“…Aberrations in signaling pathways that regulate tissue growth often lead to tumorigenesis. Homeodomain-interacting protein kinase (Hipk) family members are…”
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Correction: A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction by Sulkowski, Mikolaj J, Han, Tae Hee, Ott, Carolyn, Wang, Qi, Verheyen, Esther M, Lippincott-Schwartz, Jennifer, Serpe, Mihaela

“…[This corrects the article DOI: 10.1371/journal.pgen.1005810.]…”
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Characterization of Gfat1 ( zeppelin ) and Gfat2 , Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster by Cotsworth, Shawn, Jackson, Catherine J, Hallson, Graham, Fitzpatrick, Kathleen A, Syrzycka, Monika, Coulthard, Alistair B, Bejsovec, Amy, Marchetti, Marcella, Pimpinelli, Sergio, Wang, Simon J H, Camfield, Robert G, Verheyen, Esther M, Sinclair, Donald A, Honda, Barry M, Hilliker, Arthur J

“…The ( ) locus is known for its essential role in the development of the embryonic cuticle of . We show here that encodes ( ; ), the enzyme that catalyzes the…”
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Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation by Zeng, Yi Arial, Rahnama, Maryam, Wang, Simon, Sosu-Sedzorme, Worlanyo, Verheyen, Esther M

“…Drosophila Nemo is the founding member of the Nemo-like kinase (Nlk) family of serine/threonine protein kinases that are involved in several Wnt signal…”
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