Search Results - "Verheem, Andre"

Liver lymphatic drainage patterns follow segmental anatomy in a murine model by Frenkel, Nicola C., Poghosyan, Susanna, Verheem, André, Padera, Timothy P., Rinkes, Inne H. M. Borel, Kranenburg, Onno, Hagendoorn, Jeroen

“…The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to…”
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KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer by Küçükköse, Emre, Peters, Niek A., Ubink, Inge, van Keulen, Veere A. M., Daghighian, Roxanna, Verheem, André, Laoukili, Jamila, Kranenburg, Onno

“…Expression profiling has identified four consensus molecular subtypes (CMS1-4) in colorectal cancer (CRC). The receptor tyrosine kinase KIT has been associated…”
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Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice by Küçükköse, Emre, Heesters, Balthasar A, Villaudy, Julien, Verheem, André, Cercel, Madalina, van Hal, Susan, Boj, Sylvia F, Borel Rinkes, Inne H M, Punt, Cornelis J A, Roodhart, Jeanine M L, Laoukili, Jamila, Koopman, Miriam, Spits, Hergen, Kranenburg, Onno

“…BackgroundThe immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune…”
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Tissue clearing and immunostaining to visualize the spatial organization of vasculature and tumor cells in mouse liver by Frenkel, Nicola, Poghosyan, Susanna, van Wijnbergen, Jan Willem, van den Bent, Lotte, Wijler, Liza, Verheem, André, Borel Rinkes, Inne, Kranenburg, Onno, Hagendoorn, Jeroen

“…The liver has a complex and hierarchical segmental organization of arteries, portal veins, hepatic veins and lymphatic vessels. In-depth imaging of liver…”
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GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer by Emmink, Benjamin L, Laoukili, Jamila, Kipp, Anna P, Koster, Jan, Govaert, Klaas M, Fatrai, Szabolcs, Verheem, Andre, Steller, Ernst J A, Brigelius-Flohé, Regina, Jimenez, Connie R, Borel Rinkes, Inne H M, Kranenburg, Onno

“…Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied…”
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Maintenance of Clonogenic KIT+ Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells by Fatrai, Szabolcs, van Schelven, Susanne J, Ubink, Inge, Govaert, Klaas M, Raats, Danielle, Koster, Jan, Verheem, Andre, Borel Rinkes, Inne H.M, Kranenburg, Onno

“…Background & Aims Colon tumors contain a fraction of undifferentiated stem cell−like cancer cells with high tumorigenic potential. Little is known about the…”
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The secretome of colon cancer stem cells contains drug-metabolizing enzymes by Emmink, Benjamin L, Verheem, André, Van Houdt, Winan J., Steller, Ernst J.A., Govaert, Klaas M., Pham, Thang V., Piersma, Sander R., Borel Rinkes, Inne H.M., Jimenez, Connie R., Kranenburg, Onno

“…Drug-resistant cancer stem cells (CSCs) have been implicated in tumor recurrence following chemotherapy. However, the contribution of CSCs to drug-resistance…”
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Differentiated Human Colorectal Cancer Cells Protect Tumor-Initiating Cells From Irinotecan by Emmink, Benjamin L, Van Houdt, Winan J, Vries, Robert G, Hoogwater, Frederik J.H, Govaert, Klaas M, Verheem, Andre, Nijkamp, Maarten W, Steller, Ernst J.A, Jimenez, Connie R, Clevers, Hans, Borel Rinkes, Inne H.M, Kranenburg, Onno

“…Background & Aims Stem cells of normal tissues have resistance mechanisms that allow them to survive genotoxic insults. The stem cell–like cells of tumors are…”
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Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis by van Minnen, L. Paul, MD, PhD, Timmerman, Harro M., PhD, Lutgendorff, Femke, MD, Verheem, André, BSc, Harmsen, Wil, BSc, Konstantinov, Sergey R., PhD, Smidt, Hauke, PhD, Visser, Maarten R., MD, PhD, Rijkers, Ger T., PhD, Gooszen, Hein G., MD, PhD, Akkermans, Louis M.A., PhD

“…Background Infection of pancreatic necrosis by gut bacteria is a major cause of morbidity and mortality in patients with severe acute pancreatitis. Use of…”
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Impact of global Fxr deficiency on experimental acute pancreatitis and genetic variation in the FXR locus in human acute pancreatitis by Nijmeijer, Rian M, Schaap, Frank G, Smits, Alexander J J, Kremer, Andreas E, Akkermans, Louis M A, Kroese, Alfons B A, Rijkers, Ger T, Schipper, Marguerite E I, Verheem, André, Wijmenga, Cisca, Gooszen, Hein G, van Erpecum, Karel J

“…Infectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality…”
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Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model by Wijler, Liza A., Raats, Danielle A.E., Verheem, Andre, Otter, Anna M., Rundqvist, Helene, Dijk, Miriam, May, Anne M., Kranenburg, Onno

“…Background Physical activity is associated with a lower risk of colorectal cancer (CRC) and CRC‐specific mortality. However, evidence for a causal relationship…”
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Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis by Rychter, Jakub W., MSc, van Minnen, L. Paul, MD, PhD, Verheem, André, BSc, Timmerman, Harro M., PhD, Rijkers, Ger T., PhD, Schipper, Marguerite E.I., MD, Gooszen, Hein G., MD, PhD, Akkermans, Louis M.A., PhD, Kroese, Alfons B.A., PhD

“…Background Intestinal barrier failure during acute pancreatitis (AP) is associated with translocation of luminal bacteria, resulting in infectious…”
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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis by Laoukili, Jamila, van Schelven, Susanne, Küçükköse, Emre, Verheem, André, Goey, Kaitlyn, Koopman, Miriam, Borel Rinkes, Inne, Kranenburg, Onno

“…The presence of BRAFV600E in colorectal cancer (CRC) is associated with a higher chance of distant metastasis. Oxidative stress in disseminated tumor cells…”
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Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody by Strating, Esther, Elias, Sjoerd, van Scharrenburg, Guus, Luoto, Kaisa, Verheem, André, Borel Rinkes, Inne, Steen, Herman, Kranenburg, Onno

“…Peritoneal metastases in colorectal cancer (CRC) belong to Consensus Molecular Subtype 4 (CMS4) and are associated with poor prognosis. Conventional imaging…”
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SIRT1/PGC1a-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer by Vellinga, T.T, Borovski, T, Boer, V.C.J., de, Kranenburg, O

“…PURPOSE: Chemotherapy treatment of metastatic colon cancer ultimately fails due to development of drug resistance. Identification of chemotherapy-induced…”
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Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study by van Minnen, L Paul, Venneman, Niels G, van Dijk, Jaap E, Verheem, André, Gooszen, Hein G, Akkermans, Louis M A, van Erpecum, Karel J

“…The role of bile composition in the pathogenesis of biliary pancreatitis is unknown. The objective of this experiment was to explore the potential role of bile…”
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SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer by Vellinga, Thomas T, Borovski, Tijana, de Boer, Vincent C J, Fatrai, Szabolcs, van Schelven, Susanne, Trumpi, Kari, Verheem, Andre, Snoeren, Nikol, Emmink, Benjamin L, Koster, Jan, Rinkes, Inne H M Borel, Kranenburg, Onno

“…Chemotherapy treatment of metastatic colon cancer ultimately fails due to development of drug resistance. Identification of chemotherapy-induced changes in…”
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Atypical findings in a rat model for parenteral nutrition–induced cholestasis by Deckers-Kocken, Judith M., Nikkels, Peter G.J., Verheem, André, Houwen, Roderick H.J., Akkermans, Louis M.A.

“…The pathophysiology of parenteral nutrition–associated cholestasis (PNAC) in young children is poorly understood. The composition of the total parenteral…”
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Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer by Borovski, Tijana, Vellinga, Thomas T, Laoukili, Jamila, Santo, Evan E, Fatrai, Szabolcs, van Schelven, Susanne, Verheem, Andre, Marvin, Dieuwke L, Ubink, Inge, Borel Rinkes, Inne H M, Kranenburg, Onno

“…Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. Novel therapeutics are urgently needed, especially for tumours with…”
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Onward Spread from Liver Metastases Is a Major Cause of Multi-Organ Metastasis in a Mouse Model of Metastatic Colon Cancer by Wijler, Liza A, Viergever, Bastiaan J, Strating, Esther, van Schelven, Susanne J, Poghosyan, Susanna, Frenkel, Nicola C, Te Rietmole, Hedy, Verheem, Andre, Raats, Danielle A E, Borel Rinkes, Inne H M, Hagendoorn, Jeroen, Kranenburg, Onno

“…Colorectal cancer metastasizes predominantly to the liver but also to the lungs and the peritoneum. The presence of extra-hepatic metastases limits curative…”
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