Search Results - "Verhee, A."

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor by Eyckerman, S, Broekaert, D, Verhee, A, Vandekerckhove, J, Tavernier, J

“…The leptin system provides a link between adipose mass and the central nervous system. The appetite suppressing effects of leptin are impaired in most obese…”
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Design and application of a cytokine-receptor-based interaction trap by Eyckerman, Sven, Verhee, Annick, der Heyden, José Van, Lemmens, Irma, Ostade, Xaveer Van, Vandekerckhove, Joël, Tavernier, Jan

“…Ligand-induced clustering of type I cytokine receptor subunits leads to trans-phosphorylation and activation of associated cytosolic janus kinases (JAKs). In…”
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Identification of Receptor-Binding Domains on Human Interleukin 5 and Design of an Interleukin 5-Derived Receptor Antagonist by Tavernier, J., Tuypens, T., Verhee, A., Plaetinck, G., Devos, R., Van der Heyden, J., Guisez, Y., Oefner, C.

“…A detailed structure-function analysis of human interleukin 5 (hIL5) has been performed. The hIL5 receptor is composed of two different polypeptide chains, the…”
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A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling by Peelman, F., Vinaimont, N., Vanloo, B., Labeur, C., Rosseneu, M., Verhee, A., Verschelde, J‐L., Vanderckove, J., Tavernier, J., Seguret‐Mace, S., Duverger, N., Hutchinson, G.

“…The enzyme cholesterol lecithin acyl transferase (LCAT) shares the Ser/Asp‐Glu/His triad with lipases, esterases and proteases, but the low level of sequence…”
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Molecular Basis of the Membrane-Anchored and Two Soluble Isoforms of the Human Interleukin 5 Receptor α Subunit by Tavernier, J., Tuypens, T., Plaetinck, G., Verhee, A., Fiers, W., Devos, R.

“…By use of a 3' extension PCR strategy, cDNA clones were isolated spanning the transmembrane region and a complete cytoplasmic domain of the human interleukin 5…”
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Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5 by DEVOS, R, GUISEZ, Y, CORNELIS, S, VERHEE, A, VAN DER HEYDEN, J, MANNEBERG, M, LAHM, H.-W, FIERS, W, TAVERNIER, J, PLAETINCK, G

“…Recombinant soluble human interleukin-5 receptor alpha (shIL-5R alpha) has been expressed in COS-1 cells and in baculovirus-infected cells. The protein was…”
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Effect of mutations of N- and C-terminal charged residues on the activity of LCAT by Peelman, F, Vanloo, B, Verschelde, J L, Labeur, C, Caster, H, Taveirne, J, Verhee, A, Duverger, N, Vandekerckhove, J, Tavernier, J, Rosseneu, M

“…On the basis of structural homology calculations, we previously showed that lecithin:cholesterol acyltransferase (LCAT), like lipases, belongs to the…”
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Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT) by Peelman, Frank, Vanloo, Berlinda, Perez-Mendez, Oscar, Decout, Anne, Verschelde, Jean-Luc, Labeur, Christine, Vinaimont, Nicole, Verhee, Annick, Duverger, Nicolas, Brasseur, Robert, Vandekerckhove, Joël, Tavernier, Jan, Rosseneu, Maryvonne

“…Lecithin cholesterol acyltransferase (LCAT) is an interfacial enzyme active on both high-density (HDL) and low-density lipoproteins (LDL). Threading alignments…”
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Mapping of the Leptin Binding Sites and Design of a Leptin Antagonist by Peelman, Frank, Van Beneden, Katrien, Zabeau, Lennart, Iserentant, Hannes, Ulrichts, Peter, Defeau, Delphine, Verhee, Annick, Catteeuw, Dominiek, Elewaut, Dirk, Tavernier, Jan

“…The leptin/leptin receptor system shows strong similarities to the long-chain cytokine interleukin-6 (IL-6) and granulocyte colony-stimulating factor…”
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Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells by Tavernier, Jan, Eyckerman, Sven, Lemmens, Irma, Catteeuw, Dominiek, Verhee, Annick, Vandekerckhove, Joel, Lievens, Sam

“…Interactions between proteins are at the heart of the cellular machinery. It is therefore not surprising that altered interaction profiles caused by aberrant…”
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Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter by Roosbeek, Stein, Peelman, Frank, Verhee, Annick, Labeur, Christine, Caster, Hans, Lensink, Marc F., Cirulli, Claudia, Grooten, Johan, Cochet, Claude, Vandekerckhove, Joël, Amoresano, Angela, Chimini, Giovanna, Tavernier, Jan, Rosseneu, Maryvonne

“…In a previous characterization of the ABCA subfamily of the ATP-binding cassette (ABC) transporters, we identified potential protein kinase 2 (CK2)…”
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MAPPIT (MAmmalian Protein–Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cells by Pattyn, Els, Lavens, Delphine, Van der Heyden, José, Verhee, Annick, Lievens, Sam, Lemmens, Irma, Hallenberger, Sabine, Jochmans, Dirk, Tavernier, Jan

“…The high mutation rate of Human Immunodeficiency Virus (HIV) leads to the rapid derivation of compound-resistant virus strains and thus necessitates the…”
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Interleukin 5 regulates the isoform expression of its own receptor α-subunit by Tavernier, Jan, Van der Heyden, José, Verhee, Annick, Brusselle, Guy, Van Ostade, Xaveer, Vandekerckhove, Joël, North, Janet, Rankin, Sara M., Kay, A. Barry, Robinson, Douglas S.

“…The receptor for interleukin 5 (IL-5) consists of a cytokine-specific α chain (IL-5Rα) and a signaling β chain, which is shared with interleukin 3 (IL-3) and…”
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Identification and expression analysis of leptin-regulated immediate early response and late target genes by Waelput, W, Verhee, A, Broekaert, D, Eyckerman, S, Vandekerckhove, J, Beattie, J H, Tavernier, J

“…Using PC12 cells as an in vitro model system, we have identified a series of transcripts induced through activation of the leptin receptor. On the basis of…”
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Comparison of leptin- and interleukin-6-regulated expression of the rPAP gene family: evidence for differential co-regulatory signals by Broekaert, Daniël, Eyckerman, Sven, Lavens, Delphine, Verhee, Annick, Waelput, Wim, Vandekerckhove, Joël, Tavernier, Jan

“…The pancreatitis-associated protein (PAP)/regenerating protein (REG) family represents a complex group of small secretory proteins, which can function as acute…”
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Dimerization of the interferon type I receptor IFNaR2-2 is sufficient for induction of interferon effector genes but not for full antiviral activity by Pattyn, E, Van Ostade, X, Schauvliege, L, Verhee, A, Kalai, M, Vandekerckhove, J, Tavernier, J

“…We constructed chimeric receptors wherein the extracellular domain of the erythropoietin receptor (EpoR) was fused to the transmembrane and intracellular…”
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A Hydrophobic Cluster at the Surface of the Human Plasma Phospholipid Transfer Protein Is Critical for Activity on High Density Lipoproteins by Desrumaux, Catherine, Labeur, Christine, Verhee, Annick, Tavernier, Jan, Vandekerckhove, Joël, Rosseneu, Maryvonne, Peelman, Frank

“…The plasma phospholipid transfer protein (PLTP) belongs to the lipid transfer/lipopolysaccharide binding protein (LT/LBP) family, together with the cholesteryl…”
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Analysis of Tyr to Phe and fa/fa leptin receptor mutations in the PC12 cell line by Eyckerman, S, Waelput, W, Verhee, A, Broekaert, D, Vandekerckhove, J, Tavernier, J

“…Weight regulation through body-fat content and energy homeostasis, is regulated mainly through the actions of leptin. Herein, we analyse the effect of…”
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Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease by Vanloo, B, Peelman, F, Deschuymere, K, Taveirne, J, Verhee, A, Gouyette, C, Labeur, C, Vandekerckhove, J, Tavernier, J, Rosseneu, M

“…In order to test the hypothesis that fish-eye disease (FED) is due to a deficient activation of lecithin:cholesterol acyltransferase (LCAT) by its co-factor…”
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Neutralizing monoclonal antibodies can potentiate IL‐5 signaling by Zabeau, Lennart, Van der Heyden, José, Broekaert, Daniël, Verhee, Annick, Vandekerckhove, Joël, Wu, Sheng‐Jiun, Chaiken, Irwin, Heinrich, Peter, Behrmann, Iris, Tavernier, Jan

“…IL‐5 is a major determinant in the survival, differentiation and effector‐functions of eosinophils. It mediates its effect upon binding and activation of a…”
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