Search Results - "Verhamme, Ingrid M"

An update on factor XI structure and function by Mohammed, Bassem M., Matafonov, Anton, Ivanov, Ivan, Sun, Mao-fu, Cheng, Qiufang, Dickeson, S. Kent, Li, Chan, Sun, David, Verhamme, Ingrid M., Emsley, Jonas, Gailani, David

“…Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to thrombin generation during blood coagulation by proteolytic…”
Get full text

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation by Ivanov, Ivan, Matafonov, Anton, Sun, Mao-fu, Cheng, Qiufang, Dickeson, S.Kent, Verhamme, Ingrid M., Emsley, Jonas, Gailani, David

“…When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal…”
Get full text

Protease activity in single-chain prekallikrein by Ivanov, Ivan, Verhamme, Ingrid M., Sun, Mao-fu, Mohammed, Bassem, Cheng, Qiufang, Matafonov, Anton, Dickeson, S. Kent, Joseph, Kusumam, Kaplan, Allen P., Gailani, David

“…Prekallikrein (PK) is the precursor of the trypsin-like plasma protease kallikrein (PKa), which cleaves kininogens to release bradykinin and converts the…”
Get full text

The dimeric structure of factor XI and zymogen activation by Geng, Yipeng, Verhamme, Ingrid M., Smith, Stephen B., Sun, Mao-fu, Matafonov, Anton, Cheng, Qiufang, Smith, Stephanie A., Morrissey, James H., Gailani, David

“…Factor XI (fXI) is a homodimeric zymogen that is converted to a protease with 1 (1/2-fXIa) or 2 (fXIa) active subunits by factor XIIa (fXIIa) or thrombin. It…”
Get full text

Activation of factor XI by products of prothrombin activation by Matafonov, Anton, Sarilla, Suryakala, Sun, Mao-fu, Sheehan, John P., Serebrov, Vladimir, Verhamme, Ingrid M., Gailani, David

“…The prothrombinase complex converts prothrombin to α-thrombin through the intermediate meizothrombin (Mz-IIa). Both α-thrombin and Mz-IIa catalyze factor (F)…”
Get full text

The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III by Jacobson, Richard, Mignemi, Nicholas, Rose, Kristie, O’Rear, Lynda, Sarilla, Suryakala, Hamm, Heidi E, Barnett, Joey V, Verhamme, Ingrid M, Schoenecker, Jonathan

“…Abstract Introduction The blood coagulation system is a tightly regulated balance of procoagulant and anticoagulant factors, disruption of which can cause…”
Get full text

A novel antithrombin domain dictates the journey's end of a proteinase by Verhamme, Ingrid M.

“…Antithrombin (AT) is an anticoagulant serpin that irreversibly inactivates the clotting proteinases factor Xa and thrombin by forming covalent complexes with…”
Get full text

Rapid-reaction Kinetic Characterization of the Pathway of Streptokinase-Plasmin Catalytic Complex Formation by Verhamme, Ingrid M., Bock, Paul E.

“…Binding of the fibrinolytic proteinase plasmin (Pm) to streptokinase (SK) in a tight stoichiometric complex transforms Pm into a potent proteolytic activator…”
Get full text

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain by Ivanov, Ivan, Matafonov, Anton, Sun, Mao-fu, Mohammed, Bassem M., Cheng, Qiufang, Dickeson, S. Kent, Kundu, Suman, Verhamme, Ingrid M., Gruber, Andras, McCrae, Keith, Gailani, David

“…The plasma proteins factor XII (FXII) and prekallikrein (PK) undergo reciprocal activation to the proteases FXIIa and kallikrein by a process that is enhanced…”
Get full text

Sucrose Octasulfate Selectively Accelerates Thrombin Inactivation by Heparin Cofactor II by Sarilla, Suryakala, Habib, Sally Y., Kravtsov, Dmitri V., Matafonov, Anton, Gailani, David, Verhamme, Ingrid M.

“…Inactivation of thrombin (T) by the serpins heparin cofactor II (HCII) and antithrombin (AT) is accelerated by a heparin template between the serpin and…”
Get full text

Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region by Maddur, Ashoka A., Voehler, Markus, Panizzi, Peter, Meiler, Jens, Bock, Paul E., Verhamme, Ingrid M.

“…Fibrin (Fbn) deposits are a hallmark of staphylocoagulase (SC)-positive endocarditis. Binding of the N terminus of Staphylococcus aureus SC to host prothrombin…”
Get full text

Resolution of Conformational Activation in the Kinetic Mechanism of Plasminogen Activation by Streptokinase by Boxrud, Paul D, Verhamme, Ingrid M, Bock, Paul E

“…Streptokinase (SK) activates plasminogen (Pg) by specific binding and nonproteolytic expression of the Pg catalytic site, initiating Pg proteolysis to form the…”
Get full text

The Preferred Pathway of Glycosaminoglycan-accelerated Inactivation of Thrombin by Heparin Cofactor II by Verhamme, Ingrid M., Bock, Paul E., Jackson, Craig M.

“…Thrombin (T) inactivation by the serpin, heparin cofactor II (HCII), is accelerated by the glycosaminoglycans (GAGs) dermatan sulfate (DS) and heparin (H)…”
Get full text

A non‐circulating pool of factor XI associated with glycosaminoglycans in mice by Mohammed, Bassem M., Cheng, Qiufang, Matafonov, Anton, Verhamme, Ingrid M., Emsley, Jonas, McCrae, Keith R., McCarty, Owen J. T., Gruber, Andras, Gailani, David

“…Background The homologous plasma proteins prekallikrein and factor XI (FXI) circulate as complexes with high molecular weight kininogen. Although evidence…”
Get full text

Rapid Binding of Plasminogen to Streptokinase in a Catalytic Complex Reveals a Three-step Mechanism by Verhamme, Ingrid M., Bock, Paul E.

“…Rapid kinetics demonstrate a three-step pathway of streptokinase (SK) binding to plasminogen (Pg), the zymogen of plasmin (Pm). Formation of a fluorescently…”
Get full text

Fluorescent reporters of thrombin, heparin cofactor II, and heparin binding in a ternary complex by Verhamme, Ingrid M.

“…Thrombin inactivation by heparin cofactor II (HCII) is accelerated by ternary complex formation with heparin. The novel active-site-labeled thrombins,…”
Get full text

Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin by Maddur, Ashoka A., Kroh, Heather K., Aschenbrenner, Mary E., Gibson, Breanne H.Y., Panizzi, Peter, Sheehan, Jonathan H., Meiler, Jens, Bock, Paul E., Verhamme, Ingrid M.

“…In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune…”
Get full text

Proteases: Pivot Points in Functional Proteomics by Verhamme, Ingrid M, Leonard, Sarah E, Perkins, Ray C

“…Proteases drive the life cycle of all proteins, ensuring the transportation and activation of newly minted, would-be proteins into their functional form while…”
Get more information

Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains by Shamanaev, Aleksandr, Ivanov, Ivan, Sun, Mao-Fu, Litvak, Maxim, Srivastava, Priyanka, Mohammed, Bassem M., Shaban, Rabia, Maddur, Ashoka, Verhamme, Ingrid M., McCarty, Owen J.T., Law, Ruby H.P., Gailani, David

“…Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein to the protease plasma…”
Get full text

A Sequential Mechanism for Exosite-mediated Factor IX Activation by Factor XIa by Geng, Yipeng, Verhamme, Ingrid M., Messer, Amanda, Sun, Mao-fu, Smith, Stephen B., Bajaj, S.Paul, Gailani, David

“…During blood coagulation, the protease factor XIa (fXIa) activates factor IX (fIX). We describe a new mechanism for this process. FIX is cleaved initially…”
Get full text