Search Results - "Verhaeghe, Pierre"

Synthesis and Antiplasmodial Evaluation of 4-Carboxamido- and 4-Alkoxy-2-Trichloromethyl Quinazolines by Amrane, Dyhia, Gellis, Armand, Hutter, Sébastien, Prieri, Marion, Verhaeghe, Pierre, Azas, Nadine, Vanelle, Patrice, Primas, Nicolas

“…From three previously identified antiplasmodial hit compounds ( - ) and inactive series ( ), all based on a 2-trichloromethylquinazoline scaffold, we conducted…”
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Abdominal Incision: The Gold Standard Has Yet to be Defined by Verhaeghe, Pierre J., MD, PhD, FACS

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Anticancer and Anti-Inflammatory Activities of Some New Pyrazolo[3,4- b ]pyrazines by El-Kashef, Hussein, El-Emary, Talaat, Verhaeghe, Pierre, Vanelle, Patrice, Samy, Maha

“…New derivatives of pyrazolo[3,4- ]pyrazines and related heterocycles were synthesized using 5-amino-3-methyl-4-nitroso-1-phenyl-pyrazole ( ) as a starting…”
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Results of laparoscopic sleeve gastrectomy: A prospective study in 135 patients with morbid obesity by Fuks, David, MD, Verhaeghe, Pierre, MD, Brehant, Olivier, MD, Sabbagh, Charles, MD, Dumont, Frederic, MD, Riboulot, Michel, MD, Delcenserie, Richard, MD, Regimbeau, Jean-Marc, MD, PhD

“…Background Sleeve gastrectomy is a new restrictive bariatric procedure increasingly indicated in the treatment of morbid obesity. The authors report their…”
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Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential by Khoumeri, Omar, Hutter, Sébastien, Primas, Nicolas, Castera-Ducros, Caroline, Carvalho, Sandra, Wyllie, Susan, Efrit, Mohamed Lotfi, Fayolle, Dimitri, Since, Marc, Vanelle, Patrice, Verhaeghe, Pierre, Azas, Nadine, El-Kashef, Hussein

“…A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2-5 steps and their structure was proved by elemental and…”
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Structural simplification of the 3‐nitroimidazo[1,2‐ a ]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles by Paoli-Lombardo, Romain, Primas, Nicolas, Hutter, Sébastien, Castera-Ducros, Caroline, Jacquet, Inès, Verhaeghe, P., Azas, Nadine, Rathelot, Pascal, Vanelle, Patrice

“…As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐ a ]pyridine ring to a…”
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4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives by Lagardère, Prisca, Mustière, Romain, Amanzougaghene, Nadia, Hutter, Sébastien, Franetich, Jean-François, Azas, Nadine, Vanelle, Patrice, Verhaeghe, Pierre, Primas, Nicolas, Mazier, Dominique, Masurier, Nicolas, Lisowski, Vincent

“…Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of…”
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Two lessons from a 5-year follow-up study of laparoscopic sleeve gastrectomy: Persistent, relevant weight loss and a short surgical learning curve by Prevot, Flavien, MD, Verhaeghe, Pierre, MD, PhD, Pequignot, Aurélien, MD, Rebibo, Lionel, MD, Cosse, Cyril, MD, Dhahri, Abdennaceur, MD, Regimbeau, Jean-Marc, MD, PhD

“…Introduction Like Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy (LSG) has been validated as a bariatric surgery procedure in its own right…”
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Laparoscopic sleeve gastrectomy in patients with NASH-related cirrhosis: A case-matched study by Rebibo, Lionel, M.D, Gerin, Olivier, M.D, Verhaeghe, Pierre, M.D., Ph.D., F.A.C.S, Dhahri, Abdennaceur, M.D, Cosse, Cyril, M.D, Regimbeau, Jean-Marc, M.D., Ph.D

“…Abstract Background Laparoscopic sleeve gastrectomy (SG) is a validated procedure for the surgical treatment of morbid obesity. Cirrhosis is often considered a…”
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Is the residual gastric volume after laparoscopic sleeve gastrectomy an objective criterion for adapting the treatment strategy after failure? by Deguines, Jean-Baptiste, M.D, Verhaeghe, Pierre, M.D., F.A.C.S, Yzet, Thierry, M.D., Ph.D, Robert, Brice, M.D, Cosse, Cyril, Ph.D, Regimbeau, Jean-Marc, M.D., Ph.D

“…Abstract Background Causes of failure after laparoscopic sleeve gastrectomy (LSG) are not known but may include a high residual gastric volume (RGV). The aim…”
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Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2- a ]pyridine Antileishmanial Pharmacophore by Paoli-Lombardo, Romain, Primas, Nicolas, Bourgeade-Delmas, Sandra, Hutter, Sébastien, Sournia-Saquet, Alix, Boudot, Clotilde, Brenot, Emilie, Castera-Ducros, Caroline, Corvaisier, Sophie, Since, Marc, Malzert-Fréon, Aurélie, Courtioux, Bertrand, Valentin, Alexis, Verhaeghe, Pierre, Azas, Nadine, Rathelot, Pascal, Vanelle, Patrice

“…An antileishmanial structure−activity relationship (SAR) study focused on positions 2 and 8 of the imidazo[1,2-a]pyridine ring was conducted through the…”
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Management of gastrobronchial fistula after laparoscopic sleeve gastrectomy by Rebibo, Lionel, M.D, Dhahri, Abdennaceur, M.D, Berna, Pascal, M.D., Ph.D, Yzet, Thierry, M.D, Verhaeghe, Pierre, M.D., Ph.D., F.A.C.S, Regimbeau, Jean-Marc, M.D., Ph.D

“…Abstract Background Gastric fistula (GF) is a serious complication after laparoscopic sleeve gastrectomy (LSG). Furthermore, gastrobronchial fistula (GBF) may…”
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2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of Plasmodium falciparum by Amrane, Dyhia, Arnold, Christophe-Sébastien, Hutter, Sébastien, Sanz-Serrano, Julen, Collia, Miguel, Azqueta, Amaya, Paloque, Lucie, Cohen, Anita, Amanzougaghene, Nadia, Tajeri, Shahin, Franetich, Jean-François, Mazier, Dominique, Benoit-Vical, Françoise, Verhaeghe, Pierre, Azas, Nadine, Vanelle, Patrice, Botté, Cyrille, Primas, Nicolas

“…The malaria parasite harbors a relict plastid called the apicoplast. Although not photosynthetic, the apicoplast retains unusual, non-mammalian metabolic…”
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Sonogashira cross-coupling reaction in 4-chloro-2-trichloromethylquinazoline series is possible despite a side dimerization reaction by Kieffer, Charline, Verhaeghe, Pierre, Primas, Nicolas, Castera-Ducros, Caroline, Gellis, Armand, Rosas, Roselyne, Rault, Sylvain, Rathelot, Pascal, Vanelle, Patrice

“…We studied the Sonogashira coupling reaction between 4-chloro-2-trichloromethylquinazoline and various terminal alkynes, mainly in phenylacetylene series. A…”
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Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines by Kabri, Youssef, Verhaeghe, Pierre, Gellis, Armand, Vanelle, Patrice

“…New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by…”
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Definition of Giant Ventral Hernias: Development of Standardization through a Practice Survey by Passot, Guillaume, MD, PhD, Villeneuve, Laurent, Msc, Sabbagh, Charles, MD, Renard, Yohann, MD, Regimbeau, Jean-Marc, MD, PhD, Verhaeghe, Pierre, MD, PhD, Kianmanesh, Reza, MD, PhD, Palot, Jean-Pierre, MD, PhD, Vaudoyer, Delphine, MD, Glehen, Olivier, MD, PhD, Cotte, Eddy, MD, PhD

“…Abstract Background Giant ventral hernias represent a real handicap for patients and constitute a challenge for surgeons. European Hernia Society…”
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Effect of perioperative management on short-term outcomes after sleeve gastrectomy: a 600-patient single-center cohort study by Rebibo, Lionel, M.D, Blot, Christelle, M.D, Verhaeghe, Pierre, M.D., Ph.D., F.A.C.S, Cosse, Cyril, M.D, Dhahri, Abdennaceur, M.D, Regimbeau, Jean-Marc, M.D., Ph.D

“…Abstract Background Reports on the postoperative outcomes of sleeve gastrectomy (SG) have only been from small, single-center series and meta-analyses of…”
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Synthesis and in vitro antiplasmodial evaluation of 4-anilino-2-trichloromethylquinazolines by VERHAEGHE, Pierre, AZAS, Nadine, VANELLE, Patrice, HUTTER, Sébastien, CASTERA-DUCROS, Caroline, LAGET, Michèle, DUMETRE, Aurélien, GASQUET, Monique, REBOUL, Jean-Pierre, RAULT, Sylvain, RATHELOT, Pascal

“…To identify a new safe antiplasmodial molecular scaffold, an original series of 2-trichloromethylquinazolines, functionalized in position 4 by an alkyl- or…”
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Does sleeve gastrectomy improve the gait parameters of obese patients? by Rebibo, Lionel, M.D, Verhaeghe, Pierre, M.D., F.A.C.S, Tasseel-Ponche, Sophie, M.D, Cosse, Cyril, Ph.D, Maréchal, Virginie, M.D, Dhahri, Abdennaceur, M.D, Doutrellot, Pierre-Louis, M.D., Ph.D, Regimbeau, Jean-Marc, M.D., Ph.D

“…Abstract Background Few studies have evaluated the effect of bariatric surgery on gait parameters, which constitute an important aspect of quality of life…”
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A new synthetic route to original sulfonamide derivatives in 2-trichloromethylquinazoline series: a structure-activity relationship study of antiplasmodial activity by Primas, Nicolas, Verhaeghe, Pierre, Cohen, Anita, Kieffer, Charline, Dumètre, Aurélien, Hutter, Sébastien, Rault, Sylvain, Rathelot, Pascal, Azas, Nadine, Vanelle, Patrice

“…We report herein a simple and efficient two-step synthetic approach to new 2-trichloromethylquinazolines possessing a variously substituted sulfonamide group…”
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