Search Results - "Verhaegh, Pauline"

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease by Shami, Gerald J., Cheng, Delfine, Verhaegh, Pauline, Koek, Ger, Wisse, Eddie, Braet, Filip

“…Giant mitochondria are peculiarly shaped, extremely large mitochondria in hepatic parenchymal cells, the internal structure of which is characterised by…”
Get full text

Hyperferritinemia in Nonalcoholic Fatty Liver Disease: Iron Accumulation or Inflammation? by Moris, Wenke, Verhaegh, Pauline, Jonkers, Daisy, Deursen, Cees van, Koek, Ger

“…Hyperferritinemia, observed in inflammation, iron overload as well as in combination of both, is found in ∼30% of nonalcoholic fatty liver disease (NAFLD)…”
Get more information

Fat causes necrosis and inflammation in parenchymal cells in human steatotic liver by Wisse, Eddie, Braet, Filip, Shami, Gerald J., Zapotoczny, Bartlomiej, Vreuls, Celien, Verhaegh, Pauline, Frederik, Peter, Peters, Peters J., Olde Damink, Steven, Koek, Ger

“…Adapted fixation methods for electron microscopy allowed us to study liver cell fine structure in 217 biopsies of intact human livers over the course of…”
Get full text

Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease? by De Munck, Toon J I, Boesch, Markus, Verhaegh, Pauline, Masclee, Ad A M, Jonkers, Daisy, van Pelt, Jos F, du Plessis, Johannie, Korf, Hannelie, Nevens, Frederik, Koek, Ger H, Van der Merwe, Schalk, Verbeek, Jef

“…Neuregulin 4 (Nrg4), a novel adipokine enriched in brown adipose tissue has been observed to negatively regulate de novo hepatic lipogenesis and limit…”
Get full text

Myosteatosis in nonalcoholic fatty liver disease: An exploratory study by De Munck, Toon J.I., Verhaegh, Pauline, Lodewick, Toine, Bakers, Frans, Jonkers, Daisy, Masclee, Ad.A.M., Verbeek, Jef, Koek, Ger H.

“…•Fat infiltration in skeletal muscle (myosteatosis) may contribute to the development of insulin resistance and NAFLD.•The muscle fat and hepatic fat fraction…”
Get full text

Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis by Moris, Wenke, Verhaegh, Pauline L. M., Masclee, Ad A. M., Swinkels, Dorine W., Laarakkers, Coby M., Koek, Ger H., Deursen, Cees Th. B. M.

“…We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of…”
Get full text

The modified iron avidity index: a promising phenotypic predictor in HFE-related haemochromatosis by Verhaegh, Pauline L. M., Moris, Wenke, Koek, Ger H., van Deursen, Cees Th. B. M.

“…Objective Phenotypes of the HFE‐related haemochromatosis vary considerably, making it hard to predict the course of iron accumulation. The aim of this…”
Get full text

A gastric ulcer: double trouble by Verhaegh, Pauline, Flink, Hajo, Daniels-Gooszen, Alette, Huysentruyt, Clément, Schoon, Erik

Get full text

Response to can modifier gene mutations improve the predictive value of the modified Iron Avidity Index in Type 1 Hereditary Haemochromatosis? by Verhaegh, Pauline L. M., Moris, Wenke, Koek, Ger H., van Deursen, Cees Th. B. M

Get full text

Noninvasive Tests Do Not Accurately Differentiate Nonalcoholic Steatohepatitis From Simple Steatosis: A Systematic Review and Meta-analysis by Verhaegh, Pauline, Bavalia, Roisin, Winkens, Bjorn, Masclee, Ad, Jonkers, Daisy, Koek, Ger

“…Nonalcoholic fatty liver disease is a rapidly increasing health problem. Liver biopsy analysis is the most sensitive test to differentiate between nonalcoholic…”
Get full text

Reply by Verhaegh, Pauline, Jonkers, Daisy, Koek, Ger. H.

Get full text

The increasing burden of NAFLD fibrosis in the general population: Time to bridge the gap between hepatologists and primary care by van Asten, Marloes, Verhaegh, Pauline, Koek, Ger, Verbeek, Jef

Get full text

SAT053 - Ultrastructural changes in perfusion-fixed human non-alcoholic fatty liver disease biopsies by Verhaegh, Pauline, Wisse, Eddie, De Munck, Toon, Greve, Jan W., Verheij, Joanne, Riedl, Robert, Duimel, Hans, Masclee, Ad, Jonkers, Daisy, Koek, Ger

Get full text

Ultrastructural changes in perfusion-fixed human non-alcoholic fatty liver disease biopsies by Verhaegh, Pauline, Wisse, Eddie, De Munck, Toon, Greve, Jan W., Verheij, Joanne, Riedl, Robert, Duimel, Hans, Masclee, Ad, Jonkers, Daisy, Koek, Ger

Get full text

Electron microscopic observations in perfusion-fixed human non-alcoholic fatty liver disease biopsies by Verhaegh, Pauline, Wisse, Eddie, de Munck, Toon, Greve, Jan Willem, Verheij, Joanne, Riedl, Robert, Duimel, Hans, Masclee, Ad, Jonkers, Daisy, Koek, Ger

“…Non-alcoholic fatty liver disease (NAFLD) is a widespread liver disease in Western society, but its multifactorial pathogenesis is not yet fully understood…”
Get full text

Colonic permeability is increased in non-cirrhotic patients with nonalcoholic fatty liver disease by De Munck, Toon J.I., Verhaegh, Pauline, Spooren, Corinne, Mujagic, Zlatan, Wienhold, Tobias, Jonkers, Daisy, Masclee, Ad A.M., Koek, Ger H., Verbeek, Jef

“…Intestinal permeability (IP) plays an important role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). We assessed site-specific…”
Get full text

Reply by Verhaegh, Pauline, Jonkers, Daisy, Koek, Ger H

Get full text

Reply by Verhaegh, Pauline, Jonkers, Daisy, Koek, Ger H

Get full text

A gastric ulcer: double trouble by Verhaegh, Pauline, Flink, Hajo, Daniels-Gooszen, Alette, Huysentruyt, Clément, Schoon, Erik

Get full text

Inflammation can increase hepcidin in HFE-hereditary hemochromatosis by Moris, Wenke, Verhaegh, Pauline L M, Masclee, Ad A M, Swinkels, Dorine W, Laarakkers, Coby M, Koek, Ger H, van Deursen, Cees Th B M

“…We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of…”
Get full text