Search Results - "Verhaak, Roeland G W"

Molecular subtypes of glioblastoma are relevant to lower grade glioma by Guan, Xiaowei, Vengoechea, Jaime, Zheng, Siyuan, Sloan, Andrew E, Chen, Yanwen, Brat, Daniel J, O'Neill, Brian Patrick, de Groot, John, Yust-Katz, Shlomit, Yung, Wai-Kwan Alfred, Cohen, Mark L, Aldape, Kenneth D, Rosenfeld, Steven, Verhaak, Roeland G W, Barnholtz-Sloan, Jill S

“…Gliomas are the most common primary malignant brain tumors in adults with great heterogeneity in histopathology and clinical course. The intent was to evaluate…”
Get full text

TCPA: a resource for cancer functional proteomics data by Li, Jun, Lu, Yiling, Akbani, Rehan, Ju, Zhenlin, Roebuck, Paul L, Liu, Wenbin, Yang, Ji-Yeon, Broom, Bradley M, Verhaak, Roeland G W, Kane, David W, Wakefield, Chris, Weinstein, John N, Mills, Gordon B, Liang, Han

Get full text

Profiles of brain metastases: Prioritization of therapeutic targets by Ferguson, Sherise D., Zheng, Siyuan, Xiu, Joanne, Zhou, Shouhao, Khasraw, Mustafa, Brastianos, Priscilla K., Kesari, Santosh, Hu, Jethro, Rudnick, Jeremy, Salacz, Michael E., Piccioni, David, Huang, Suyun, Davies, Michael A., Glitza, Isabella C., Heymach, John V., Zhang, Jianjun, Ibrahim, Nuhad K., DeGroot, John F., McCarty, Joseph, O'Brien, Barbara J., Sawaya, Raymond, Verhaak, Roeland G.W., Reddy, Sandeep K., Priebe, Waldemar, Gatalica, Zoran, Spetzler, David, Heimberger, Amy B.

“…We sought to compare the tumor profiles of brain metastases from common cancers with those of primary tumors and extracranial metastases in order to identify…”
Get full text

A Need for More Molecular Profiling in Brain Metastases by Shen, Erica, Van Swearingen, Amanda E D, Price, Meghan J, Bulsara, Ketan, Verhaak, Roeland G W, Baëta, César, Painter, Brice D, Reitman, Zachary J, Salama, April K S, Clarke, Jeffrey M, Anders, Carey K, Fecci, Peter E, Goodwin, C Rory, Walsh, Kyle M

“…As local disease control improves, the public health impact of brain metastases (BrM) continues to grow. Molecular features are frequently different between…”
Get full text

Comprehensive molecular characterization of urothelial bladder carcinoma by Weinstein, John N, Akbani, Rehan, Broom, Bradley M, Wang, Wenyi, Verhaak, Roeland G. W, McConkey, David

“…Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents…”
Get full text

The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes by Han, Leng, Yuan, Yuan, Zheng, Siyuan, Yang, Yang, Li, Jun, Edgerton, Mary E., Diao, Lixia, Xu, Yanxun, Verhaak, Roeland G. W., Liang, Han

“…Although individual pseudogenes have been implicated in tumour biology, the biomedical significance and clinical relevance of pseudogene expression have not…”
Get full text

A pan-cancer proteomic perspective on The Cancer Genome Atlas by Akbani, Rehan, Ng, Patrick Kwok Shing, Werner, Henrica M. J., Shahmoradgoli, Maria, Zhang, Fan, Ju, Zhenlin, Liu, Wenbin, Yang, Ji-Yeon, Yoshihara, Kosuke, Li, Jun, Ling, Shiyun, Seviour, Elena G., Ram, Prahlad T., Minna, John D., Diao, Lixia, Tong, Pan, Heymach, John V., Hill, Steven M., Dondelinger, Frank, Städler, Nicolas, Byers, Lauren A., Meric-Bernstam, Funda, Weinstein, John N., Broom, Bradley M., Verhaak, Roeland G. W., Liang, Han, Mukherjee, Sach, Lu, Yiling, Mills, Gordon B.

“…Protein levels and function are poorly predicted by genomic and transcriptomic analysis of patient tumours. Therefore, direct study of the functional proteome…”
Get full text

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth by Hu, Baoli, Wang, Qianghu, Wang, Y. Alan, Hua, Sujun, Sauvé, Charles-Etienne Gabriel, Ong, Derrick, Lan, Zheng D., Chang, Qing, Ho, Yan Wing, Monasterio, Marta Moreno, Lu, Xin, Zhong, Yi, Zhang, Jianhua, Deng, Pingna, Tan, Zhi, Wang, Guocan, Liao, Wen-Ting, Corley, Lynda J., Yan, Haiyan, Zhang, Junxia, You, Yongping, Liu, Ning, Cai, Linbo, Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Spring, Denise J., Hu, Jian, Sulman, Erik P., Fuller, Gregory N., Chin, Lynda, Verhaak, Roeland G.W., DePinho, Ronald A.

“…Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. To illuminate mechanisms governing these…”
Get full text

Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm by Martinez-Ledesma, Emmanuel, Verhaak, Roeland G.W., Treviño, Victor

“…Cancer types are commonly classified by histopathology and more recently through molecular characteristics such as gene expression, mutations, copy number…”
Get full text

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer by Liang, Han, Cheung, Lydia W T, Li, Jie, Ju, Zhenlin, Yu, Shuangxing, Stemke-Hale, Katherine, Dogruluk, Turgut, Lu, Yiling, Liu, Xiuping, Gu, Chao, Guo, Wei, Scherer, Steven E, Carter, Hannah, Westin, Shannon N, Dyer, Mary D, Verhaak, Roeland G W, Zhang, Fan, Karchin, Rachel, Liu, Chang-Gong, Lu, Karen H, Broaddus, Russell R, Scott, Kenneth L, Hennessy, Bryan T, Mills, Gordon B

“…Endometrial cancer is the most common gynecological malignancy, with more than 280,000 cases occurring annually worldwide. Although previous studies have…”
Get full text

SubcloneSeeker: a computational framework for reconstructing tumor clone structure for cancer variant interpretation and prioritization by Qiao, Yi, Quinlan, Aaron R, Jazaeri, Amir A, Verhaak, Roeland Gw, Wheeler, David A, Marth, Gabor T

“…Many tumors are composed of genetically divergent cell subpopulations. We report SubcloneSeeker, a package capable of exhaustive identification of subclone…”
Get full text

Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation by Shingu, Takashi, Ho, Allen L, Yuan, Liang, Zhou, Xin, Dai, Congxin, Zheng, Siyuan, Wang, Qianghu, Zhong, Yi, Chang, Qing, Horner, James W, Liebelt, Brandon D, Yao, Yu, Hu, Baoli, Chen, Yiwen, Fuller, Gregory N, Verhaak, Roeland G W, Heimberger, Amy B, Hu, Jian

“…Jian Hu and colleagues use mouse models to show that Qki deficiency promotes gliomagenesis by allowing neural stem cells to maintain their stemness outside the…”
Get full text

Abstract 351: Gliomagenesis via the reactivation of quiescent adult oligodendrocyte precursor cells by Galvao, Rui P., Verhaak, Roeland G. W., Foreman, Oded, Zong, Hui

“…Abstract Malignant gliomas are devastating, incurable brain tumors. Surprisingly, though the proliferative activity of brain cells decreases precipitously with…”
Get full text

Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas by Akbani, Rehan, Ng, Patrick Kwok Shing, Werner, Henrica M J, Shahmoradgoli, Maria, Zhang, Fan, Ju, Zhenlin, Liu, Wenbin, Yang, Ji-Yeon, Yoshihara, Kosuke, Li, Jun, Ling, Shiyun, Seviour, Elena G, Ram, Prahlad T, Minna, John D, Diao, Lixia, Tong, Pan, Heymach, John V, Hill, Steven M, Dondelinger, Frank, Städler, Nicolas, Byers, Lauren A, Meric-Bernstam, Funda, Weinstein, John N, Broom, Bradley M, Verhaak, Roeland G W, Liang, Han, Mukherjee, Sach, Lu, Yiling, Mills, Gordon B

Get full text

MRI-Guided Stereotactic Biopsy of Murine GBM for Spatiotemporal Molecular Genomic Assessment by Galbán, Stefanie, Al-Holou, Wajd N, Wang, Hanxiao, Welton, Amanda R, Heist, Kevin, Hu, Xin Kathy, Verhaak, Roeland Gw, Zhu, Yuan, Espinoza, Carlos, Chenevert, Thomas L, Hoff, Ben A, Galbán, Craig J, Ross, Brian D

“…Brain tumor biopsies that are routinely performed in clinical settings significantly aid in diagnosis and staging. The aim of this study is to develop and…”
Get full text

Abstract B130: The intratumoral heterogeneity of glioblastoma suggests a pivotal role for clonal evolution by Kim, Hoon, Zheng, Siyuan, Amini, Seyed S., Virk, Selene, Mikkelsen, Tom, Brat, Daniel J., Grimsby, Jonna, Sougnez, Carrie, Sloan, Andrew E., Cohen, Mark L., Van Meir, Erwin G., Scarpace, Lisa, Laird, Peter W., Weinstein, John N., Lander, Eric S., Gabriel, Stacey, Getz, Gaddy, Meyerson, Matthew, Chin, Lynda, Barnholtz-Sloan, Jill S., Verhaak, Roeland GW

“…Abstract To investigate therapy induced evolutionary patterns in glioblastoma (GBM), we completed whole exome sequencing of all samples, as well as…”
Get full text