Search Results - "Verhaak, Roel G. W"

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution by Verhaak, Roel G. W., Bafna, Vineet, Mischel, Paul S.

“…Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA (ecDNA) is a frequent event in cancer, providing new momentum to explore a…”
Get full text

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas by Oldrini, Barbara, Vaquero-Siguero, Nuria, Mu, Quanhua, Kroon, Paula, Zhang, Ying, Galán-Ganga, Marcos, Bao, Zhaoshi, Wang, Zheng, Liu, Hanjie, Sa, Jason K., Zhao, Junfei, Kim, Hoon, Rodriguez-Perales, Sandra, Nam, Do-Hyun, Verhaak, Roel G. W., Rabadan, Raul, Jiang, Tao, Wang, Jiguang, Squatrito, Massimo

“…Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and is now becoming a chemotherapeutic option in patients diagnosed with…”
Get full text

Reconstructing the molecular life history of gliomas by Barthel, Floris P., Wesseling, Pieter, Verhaak, Roel G. W.

“…At the time of their clinical manifestation, the heterogeneous group of adult and pediatric gliomas carries a wide range of diverse somatic genomic…”
Get full text

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas by Campbell, Joshua D, Alexandrov, Anton, Kim, Jaegil, Wala, Jeremiah, Berger, Alice H, Pedamallu, Chandra Sekhar, Shukla, Sachet A, Guo, Guangwu, Brooks, Angela N, Murray, Bradley A, Imielinski, Marcin, Hu, Xin, Ling, Shiyun, Akbani, Rehan, Rosenberg, Mara, Cibulskis, Carrie, Ramachandran, Aruna, Collisson, Eric A, Kwiatkowski, David J, Lawrence, Michael S, Weinstein, John N, Verhaak, Roel G W, Wu, Catherine J, Hammerman, Peter S, Cherniack, Andrew D, Getz, Gad, Artyomov, Maxim N, Schreiber, Robert, Govindan, Ramaswamy, Meyerson, Matthew

“…Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell…”
Get full text

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation by Koivunen, Peppi, Lee, Sungwoo, Duncan, Christopher G., Lopez, Giselle, Lu, Gang, Ramkissoon, Shakti, Losman, Julie A., Joensuu, Päivi, Bergmann, Ulrich, Gross, Stefan, Travins, Jeremy, Weiss, Samuel, Looper, Ryan, Ligon, Keith L., Verhaak, Roel G. W., Yan, Hai, Kaelin Jr, William G.

“…The ( R )-enantiomer of 2-hydroxyglutarate, which is produced when IDH is mutated in human tumours, is shown to stimulate the activity of the EGLN prolyl…”
Get full text

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma by Sa, Jason K, Chang, Nakho, Lee, Hye Won, Cho, Hee Jin, Ceccarelli, Michele, Cerulo, Luigi, Yin, Jinlong, Kim, Sung Soo, Caruso, Francesca P, Lee, Mijeong, Kim, Donggeon, Oh, Young Taek, Lee, Yeri, Her, Nam-Gu, Min, Byeongkwi, Kim, Hye-Jin, Jeong, Da Eun, Kim, Hye-Mi, Kim, Hyunho, Chung, Seok, Woo, Hyun Goo, Lee, Jeongwu, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Kim, Jinho, Park, Woong-Yang, Wang, Qianghu, Sulman, Erik P, Heimberger, Amy B, Lim, Michael, Park, Jong Bae, Iavarone, Antonio, Verhaak, Roel G W, Nam, Do-Hyun

“…Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes;…”
Get full text

Perspective of mesenchymal transformation in glioblastoma by Kim, Yona, Varn, Frederick S, Park, Sung-Hye, Yoon, Byung Woo, Park, Hye Ran, Lee, Charles, Verhaak, Roel G W, Paek, Sun Ha

“…Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain tumor, still portends a poor prognosis with a median overall survival of…”
Get full text

Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium by Yamaguchi, Manako, Nakaoka, Hirofumi, Suda, Kazuaki, Yoshihara, Kosuke, Ishiguro, Tatsuya, Yachida, Nozomi, Saito, Kyota, Ueda, Haruka, Sugino, Kentaro, Mori, Yutaro, Yamawaki, Kaoru, Tamura, Ryo, Revathidevi, Sundaramoorthy, Motoyama, Teiichi, Tainaka, Kazuki, Verhaak, Roel G. W., Inoue, Ituro, Enomoto, Takayuki

“…It has become evident that somatic mutations in cancer-associated genes accumulate in the normal endometrium, but spatiotemporal understanding of the evolution…”
Get full text

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain by Geisenberger, Christoph, Mock, Andreas, Warta, Rolf, Rapp, Carmen, Schwager, Christian, Korshunov, Andrey, Nied, Ann-Katrin, Capper, David, Brors, Benedikt, Jungk, Christine, Jones, David, Collins, V. Peter, Ichimura, Koichi, Bäcklund, L. Magnus, Schnabel, Elena, Mittelbron, Michel, Lahrmann, Bernd, Zheng, Siyuan, Verhaak, Roel G. W., Grabe, Niels, Pfister, Stefan M., Hartmann, Christian, von Deimling, Andreas, Debus, Jürgen, Unterberg, Andreas, Abdollahi, Amir, Herold-Mende, Christel

“…Glioblastoma (GBM) is a devastating tumor and few patients survive beyond 3 years. Defining the molecular determinants underlying long-term survival is…”
Get full text

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy by Tanner, Georgette, Barrow, Rhiannon, Ajaib, Shoaib, Al-Jabri, Muna, Ahmed, Nazia, Pollock, Steven, Finetti, Martina, Rippaus, Nora, Bruns, Alexander F, Syed, Khaja, Poulter, James A, Matthews, Laura, Hughes, Thomas, Wilson, Erica, Johnson, Colin, Varn, Frederick S, Brüning-Richardson, Anke, Hogg, Catherine, Droop, Alastair, Gusnanto, Arief, Care, Matthew A, Cutillo, Luisa, Westhead, David R, Short, Susan C, Jenkinson, Michael D, Brodbelt, Andrew, Chakrabarty, Aruna, Ismail, Azzam, Verhaak, Roel G W, Stead, Lucy F

“…Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy…”
Get full text

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine by Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.

“…Homozygous deletion of methylthioadenosine phosphorylase ( MTAP ) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous…”
Get full text

The cellular origin for malignant glioma and prospects for clinical advancements by Zong, Hui, Verhaak, Roel G W, Canoll, Peter

“…Glioma remains incurable despite great advancements in medicine. Targeting the cell of origin for gliomas could bring great hope for patients. However, as a…”
Get more information

Circular ecDNA promotes accessible chromatin and high oncogene expression by Wu, Sihan, Turner, Kristen M., Nguyen, Nam, Raviram, Ramya, Erb, Marcella, Santini, Jennifer, Luebeck, Jens, Rajkumar, Utkrisht, Diao, Yarui, Li, Bin, Zhang, Wenjing, Jameson, Nathan, Corces, M. Ryan, Granja, Jeffrey M., Chen, Xingqi, Coruh, Ceyda, Abnousi, Armen, Houston, Jack, Ye, Zhen, Hu, Rong, Yu, Miao, Kim, Hoon, Law, Julie A., Verhaak, Roel G. W., Hu, Ming, Furnari, Frank B., Chang, Howard Y., Ren, Bing, Bafna, Vineet, Mischel, Paul S.

“…Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer 1 , 2 , but our understanding of the structure of ecDNA and its effect…”
Get full text

Extrachromosomal DNA amplifications in cancer by Yi, Eunhee, Chamorro González, Rocío, Henssen, Anton G., Verhaak, Roel G. W.

“…Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated with worse…”
Get full text

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma by Eskilsson, Eskil, Røsland, Gro V, Solecki, Gergely, Wang, Qianghu, Harter, Patrick N, Graziani, Grazia, Verhaak, Roel G W, Winkler, Frank, Bjerkvig, Rolf, Miletic, Hrvoje

“…Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing…”
Get full text

TumorFusions: an integrative resource for cancer-associated transcript fusions by Hu, Xin, Wang, Qianghu, Tang, Ming, Barthel, Floris, Amin, Samirkumar, Yoshihara, Kosuke, Lang, Frederick M, Martinez-Ledesma, Emmanuel, Lee, Soo Hyun, Zheng, Siyuan, Verhaak, Roel G W

“…Abstract Gene fusion represents a class of molecular aberrations in cancer and has been exploited for therapeutic purposes. In this paper we describe…”
Get full text

Systematic analysis of telomere length and somatic alterations in 31 cancer types by Barthel, Floris P, Wei, Wei, Tang, Ming, Martinez-Ledesma, Emmanuel, Hu, Xin, Amin, Samirkumar B, Akdemir, Kadir C, Seth, Sahil, Song, Xingzhi, Wang, Qianghu, Lichtenberg, Tara, Hu, Jian, Zhang, Jianhua, Zheng, Siyuan, Verhaak, Roel G W

“…Siyuan Zheng, Roel Verhaak and colleagues report an analysis of telomere lengths and somatic alterations in telomere-related pathways across 31 cancer types…”
Get full text

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions by Wen, Patrick Y, Weller, Michael, Lee, Eudocia Quant, Alexander, Brian M, Barnholtz-Sloan, Jill S, Barthel, Floris P, Batchelor, Tracy T, Bindra, Ranjit S, Chang, Susan M, Chiocca, E Antonio, Cloughesy, Timothy F, DeGroot, John F, Galanis, Evanthia, Gilbert, Mark R, Hegi, Monika E, Horbinski, Craig, Huang, Raymond Y, Lassman, Andrew B, Le Rhun, Emilie, Lim, Michael, Mehta, Minesh P, Mellinghoff, Ingo K, Minniti, Giuseppe, Nathanson, David, Platten, Michael, Preusser, Matthias, Roth, Patrick, Sanson, Marc, Schiff, David, Short, Susan C, Taphoorn, Martin J B, Tonn, Joerg-Christian, Tsang, Jonathan, Verhaak, Roel G W, von Deimling, Andreas, Wick, Wolfgang, Zadeh, Gelareh, Reardon, David A, Aldape, Kenneth D, van den Bent, Martin J

“…Abstract Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have…”
Get full text

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells by Rosenbauer, Frank, Bruns, Ingmar, Steidl, Christian, Wagner, Katharina, Aivado, Manuel, Delwel, Ruud, Passegué, Emmanuelle, Klippel, Steffen, Otu, Hasan H, Valk, Peter J M, Verhaak, Roel G W, Ebralidze, Alexander, Costa, Daniel B, Steidl, Ulrich, Tenen, Daniel G, Gu, Xuesong, Libermann, Towia A, Kobbe, Guido

“…Knockdown of the transcription factor PU.1 (encoded by Sfpi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of preleukemic…”
Get full text

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma by deCarvalho, Ana C., Kim, Hoon, Poisson, Laila M., Winn, Mary E., Mueller, Claudius, Cherba, David, Koeman, Julie, Seth, Sahil, Protopopov, Alexei, Felicella, Michelle, Zheng, Siyuan, Multani, Asha, Jiang, Yongying, Zhang, Jianhua, Nam, Do-Hyun, Petricoin, Emanuel F., Chin, Lynda, Mikkelsen, Tom, Verhaak, Roel G. W.

“…To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the…”
Get full text