Search Results - "Vergassola, Matteo"
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Presynaptic Release-regulating Metabotropic Glutamate Receptors: An Update
Published in Current neuropharmacology (01-01-2020)“…Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in…”
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Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings
Published in Frontiers in molecular neuroscience (18-09-2018)“…Mouse cortical GABAergic synaptosomes possess presynaptic inhibitory GABAB autoreceptors. Accordingly, (±)baclofen (3 µM) inhibits in a CGP53423-sensitive…”
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3
Trazodone counteracts the response of microglial cells to inflammatory stimuli
Published in The European journal of neuroscience (01-10-2024)“…Microglia are resident brain cells that regulate neuronal development and innate immunity. Microglia activation participates in the cellular response to…”
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Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases
Published in Molecular neurobiology (01-09-2019)“…Mouse hippocampal glutamatergic nerve endings express presynaptic release-regulating NMDA autoreceptors (NMDARs). The presence of GluN1, GluN2A, GluN2B, and…”
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α‐Glyceryl‐phosphoryl‐ethanolamine protects human hippocampal neurons from ageing‐induced cellular alterations
Published in The European journal of neuroscience (01-09-2022)“…Brain ageing has been related to a decrease in cellular metabolism, to an accumulation of misfolded proteins and to an alteration of the lipid membrane…”
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Prolonged activation of CXCR4 hampers the release-regulating activity of presynaptic NMDA receptors in rat hippocampal synaptosomes
Published in Neurochemistry international (01-06-2019)“…We investigated the impact of the prolonged exposure of rat hippocampal synaptosomes to CXCL12 (3 nM) on the NMDA-mediated release of [3H]D-aspartate…”
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Immuno‐pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord
Published in British journal of pharmacology (01-12-2017)“…Background and Purpose We recently proposed the existence of mGlu3‐preferring autoreceptors in spinal cord terminals and of mGlu2‐preferring autoreceptors in…”
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Patch clamp study of benzydamine effect over neuronal excitability on inflammation sensitized rat nociceptors
Published in Biophysical journal (10-02-2023)Get full text
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9
Influence of permeability enhancers on in vitro peptides delivery through STRAT-M® membranes
Published in Journal of drug delivery science and technology (01-11-2023)“…HR9 (Ac-HYWRELQYR-NH2) is an innovative and proprietary peptide designed to ameliorate skin disorders mediated by neuronal exocytosis. Its topical delivery…”
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5-HT2A-mGlu2/3 receptor complex in rat spinal cord glutamatergic nerve endings: A 5-HT2A to mGlu2/3 signalling to amplify presynaptic mechanism of auto-control of glutamate exocytosis
Published in Neuropharmacology (01-05-2018)“…Presynaptic mGlu2/3 autoreceptors exist in rat spinal cord nerve terminals as suggested by the finding that LY379268 inhibited the 15 mM KCl-evoked release of…”
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The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia
Published in Schizophrenia bulletin (01-12-2020)“…Abstract Cinnabarinic acid (CA) is a kynurenine metabolite that activates mGlu4 metabotropic glutamate receptors. Using a highly sensitive ultra-performance…”
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Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission
Published in Neuropharmacology (01-11-2020)“…Previous studies have shown that injection of the mGlu5 receptor positive allosteric modulator (PAM) VU0360172 into either the thalamus or somatosensory cortex…”
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13
Benzydamine plays a role in limiting inflammatory pain induced by neuronal sensitization
Published in Molecular pain (01-01-2023)“…Benzydamine is an active pharmaceutical compound used in the oral care pharmaceutical preparation as NSAID. Beside from its anti-inflammatory action,…”
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14
A specific combination of nutraceutical Ingredients exerts cytoprotective effects in human cholinergic neurons
Published in PharmaNutrition (01-12-2022)Get full text
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15
Design and validation of neuronal exocytosis blocking peptides as potential novel antiperspirants
Published in Experimental dermatology (01-07-2023)“…Thermoregulation and heat dissipation by sweat production and evaporation are vital for human survival. However, hyperhidrosis or excessive perspiration might…”
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Effect of Sodium Hypochlorite 0.05% on MMP-9 Extracellular Release in Chronic Wounds
Published in Journal of clinical medicine (28-04-2023)“…In chronic wounds, high concentrations of matrix metalloproteinases (MMPs) can cause excessive proteolysis and slow wound healing. Consequently, restoring a…”
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Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-Gαq Sweat Signaling Cascade
Published in International journal of peptide research and therapeutics (15-07-2024)“…Sweat production is vital for human survival as its evaporation eases heat dissipation. Nevertheless, excessive perspiration or hyperhidrosis causes stress and…”
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Presynaptic mGlu1 Receptors Control GABA B Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings
Published in Frontiers in molecular neuroscience (2018)“…Mouse cortical GABAergic synaptosomes possess presynaptic inhibitory GABA autoreceptors. Accordingly, (±)baclofen (3 μM) inhibits in a CGP53423-sensitive…”
Get full text
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5-HT 2A -mGlu2/3 receptor complex in rat spinal cord glutamatergic nerve endings: A 5-HT 2A to mGlu2/3 signalling to amplify presynaptic mechanism of auto-control of glutamate exocytosis
Published in Neuropharmacology (27-02-2018)“…Presynaptic mGlu2/3 autoreceptors exist in rat spinal cord nerve terminals as suggested by the finding that LY379268 inhibited the 15 mM KCl-evoked release of…”
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