Search Results - "Veres, Samuel P."

Collagen fibrils in functionally distinct tendons have differing structural responses to tendon rupture and fatigue loading by Herod, Tyler W., Chambers, Neil C., Veres, Samuel P.

“…[Display omitted] In this study we investigate relationships between the nanoscale structure of collagen fibrils and the macroscale functional response of…”
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Use of tendon to produce decellularized sheets of mineralized collagen fibrils for bone tissue repair and regeneration by Grue, Brendan H., Veres, Samuel P.

“…With demand for alternatives to autograft and allograft materials continuing to rise, development of new scaffolds for bone tissue repair and regeneration…”
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Designed to Fail: A Novel Mode of Collagen Fibril Disruption and Its Relevance to Tissue Toughness by Veres, Samuel P., Lee, J. Michael

“…Collagen fibrils are nanostructured biological cables essential to the structural integrity of many of our tissues. Consequently, understanding the structural…”
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Effect of increasing mineralization on pre-osteoblast response to native collagen fibril scaffolds for bone tissue repair and regeneration by Grue, Brendan H, Veres, Samuel P

“…With limited availability of auto- and allografts, there is increasing demand for alternative bone repair and regeneration materials. Inspired by a mimetic…”
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Bowstring Stretching and Quantitative Imaging of Single Collagen Fibrils via Atomic Force Microscopy by Quigley, Andrew S, Veres, Samuel P, Kreplak, Laurent

“…Collagen is the primary structural protein in animals. Serving as nanoscale biological ropes, collagen fibrils are responsible for providing strength to a…”
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Alternate soaking enables easy control of mineralized collagen scaffold mechanics from nano- to macro-scale by Grue, Brendan H., Vincent, Luke C., Kreplak, Laurent, Veres, Samuel P.

“…The mechanical properties of biologic scaffolds are critical to cellular interactions and hence functional response within the body. In the case of scaffolds…”
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ISSLS Prize Winner: How Loading Rate Influences Disc Failure Mechanics: A Microstructural Assessment of Internal Disruption by VERES, Samuel P, ROBERTSON, Peter A, BROOM, Neil D

“…Mechanically induced disruption and subsequent microscopic investigation of lumbar intervertebral discs following a previously published testing protocol, but…”
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Single collagen fibrils isolated from high stress and low stress tendons show differing susceptibility to enzymatic degradation by the interstitial collagenase matrix metalloproteinase-1 (MMP-1) by Gsell, Kelsey Y., Veres, Samuel P., Kreplak, Laurent

“…•Collagen fibril enzymatic degradation was measured using atomic force microscopy.•Fibrils from low-stress positional tendons decreased in size on exposure to…”
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High spatial resolution (1.1 μm and 20 nm) FTIR polarization contrast imaging reveals pre-rupture disorder in damaged tendon by Wiens, Richard, Findlay, Catherine R, Baldwin, Samuel G, Kreplak, Laurent, Lee, J Michael, Veres, Samuel P, Gough, Kathleen M

“…Collagen is a major constituent in many life forms; in mammals, collagen appears as a component of skin, bone, tendon and cartilage, where it performs critical…”
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The Morphology of Acute Disc Herniation: A Clinically Relevant Model Defining the Role of Flexion by VERES, Samuel P, ROBERTSON, Peter A, BROOM, Neil D

“…Hydrostatically induced disruption of flexed lumbar intervertebral discs followed by microstructural investigation. To investigate how flexion affects the…”
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Advanced glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon by Lee, J Michael, Veres, Samuel P

“…Advanced glycation end-products (AGEs) are formed in vivo from the nonenzymatic reaction between sugars and proteins. AGEs accumulate in long-lived tissues…”
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Histological staining alters circular dichroism SHG measurements of collagen by Harvey, MacAulay, Lane, Breanna, Cisek, Richard, Veres, Samuel P, Kreplak, Laurent, Tokarz, Danielle

“…Circular dichroism second harmonic generation microscopy (CDSHG) is a powerful imaging technique, which allows three-dimensional visualization of collagen…”
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Effect of testing temperature on the nanostructural response of tendon to tensile mechanical overload by KarisAllen, Jason J., Veres, Samuel P.

“…Despite many in vitro mechanical experiments of tendon being conducted at room temperature, few assessments have been made to determine how the structural…”
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In tendons, differing physiological requirements lead to functionally distinct nanostructures by Quigley, Andrew S., Bancelin, Stéphane, Deska-Gauthier, Dylan, Légaré, François, Kreplak, Laurent, Veres, Samuel P.

“…The collagen-based tissues of animals are hierarchical structures: even tendon, the simplest collagenous tissue, has seven to eight levels of hierarchy…”
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Development of overuse tendinopathy: A new descriptive model for the initiation of tendon damage during cyclic loading by Herod, Tyler W., Veres, Samuel P.

“…ABSTRACT Tendinopathic tissue has long been characterized by changes to collagen microstructure. However, initial tendon damage from excessive mechanical…”
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Ultrastructure of tendon rupture depends on strain rate and tendon type by Chambers, Neil C., Herod, Tyler W., Veres, Samuel P.

“…ABSTRACT Previous research has shown that both the mechanics and elongation mechanisms of tendon and ligament vary with strain rate during tensile loading. In…”
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ISSLS PRIZE IN BASIC SCIENCE 2020: Beyond microstructure—circumferential specialization within the lumbar intervertebral disc annulus extends to collagen nanostructure, with counterintuitive relationships to macroscale material properties by Herod, Tyler W., Veres, Samuel P.

“…Purpose To determine whether the annulus of lumbar intervertebral discs contains circumferential specialization in collagen nanostructure and assess whether…”
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Mechanically overloading collagen fibrils uncoils collagen molecules, placing them in a stable, denatured state by Veres, Samuel P., Harrison, Julia M., Lee, J. Michael

“…Due to the high occurrence rate of overextension injuries to tendons and ligaments, it is important to understand the fundamental mechanisms of damage to these…”
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Repeated subrupture overload causes progression of nanoscaled discrete plasticity damage in tendon collagen fibrils by Veres, Samuel P., Harrison, Julia M., Lee, J. Michael

“…A critical feature of tendons and ligaments is their ability to resist rupture when overloaded, resulting in strains or sprains instead of ruptures. To treat…”
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Ultrastructural response of tendon to excessive level or duration of tensile load supports that collagen fibrils are mechanically continuous by Hijazi, Khaled M., Singfield, Kathy L., Veres, Samuel P.

“…The basic collagen fibril structure of tendons continues to be debated in the literature. Some studies have proposed that collagen fibrils are longitudinally…”
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