Search Results - "Vereecke, Stijn"

Hallmarks of ribosomopathies by Kampen, Kim R, Sulima, Sergey O, Vereecke, Stijn, De Keersmaecker, Kim

“…Abstract Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with a role in ribosome assembly. Intriguingly, congenital…”
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Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells by Kampen, Kim R., Fancello, Laura, Girardi, Tiziana, Rinaldi, Gianmarco, Planque, Mélanie, Sulima, Sergey O., Loayza-Puch, Fabricio, Verbelen, Benno, Vereecke, Stijn, Verbeeck, Jelle, Op de Beeck, Joyce, Royaert, Jonathan, Vermeersch, Pieter, Cassiman, David, Cools, Jan, Agami, Reuven, Fiers, Mark, Fendt, Sarah-Maria, De Keersmaecker, Kim

“…Somatic ribosomal protein mutations have recently been described in cancer, yet their impact on cellular transcription and translation remains poorly…”
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Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth by Geeraerts, Shauni Lien, Kampen, Kim Rosalie, Rinaldi, Gianmarco, Gupta, Purvi, Planque, Mélanie, Louros, Nikolaos, Heylen, Elien, De Cremer, Kaat, De Brucker, Katrijn, Vereecke, Stijn, Verbelen, Benno, Vermeersch, Pieter, Schymkowitz, Joost, Rousseau, Frederic, Cassiman, David, Fendt, Sarah-Maria, Voet, Arnout, Cammue, Bruno P A, Thevissen, Karin, De Keersmaecker, Kim

“…Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular…”
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Ribosomal Lesions Promote Oncogenic Mutagenesis by Sulima, Sergey O, Kampen, Kim R, Vereecke, Stijn, Pepe, Daniele, Fancello, Laura, Verbeeck, Jelle, Dinman, Jonathan D, De Keersmaecker, Kim

“…Ribosomopathies are congenital disorders caused by mutations in ribosomal proteins (RP) or assembly factors and are characterized by cellular hypoproliferation…”
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Exploitation of the ribosomal protein L10 R98S mutation to enhance recombinant protein production in mammalian cells by Verbelen, Benno, Girardi, Tiziana, Sulima, Sergey O., Vereecke, Stijn, Verstraete, Paulien, Verbeeck, Jelle, Royaert, Jonathan, Cinque, Sonia, Montanaro, Lorenzo, Penzo, Marianna, Imbrechts, Maya, Geukens, Nick, Geuens, Thomas, Dierckx, Koen, Pepe, Daniele, Kampen, Kim, De Keersmaecker, Kim

“…Mammalian cells are commonly used to produce recombinant protein therapeutics, but suffer from a high cost per mg of protein produced. There is therefore great…”
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Correction: The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL by Kampen, Kim R., Sulima, Sergey O., Verbelen, Benno, Girardi, Tiziana, Vereecke, Stijn, Fancello, Laura, Rinaldi, Gianmarco, Verbeeck, Jelle, Op de Beeck, Joyce, Uyttebroeck, Anne, Meijerink, Jules P. P., Moorman, Anthony V., Harrison, Christine J., Spincemaille, Pieter, Cools, Jan, Cassiman, David, Fendt, Sarah-Maria, Vermeersch, Pieter, De Keersmaecker, Kim

“…Following the publication of this article, the authors noted that Dr Laura Fancello was not listed among the authors. The corrected author list is given below…”
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The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL by Kampen, Kim R., Sulima, Sergey O., Verbelen, Benno, Girardi, Tiziana, Vereecke, Stijn, Rinaldi, Gianmarco, Verbeeck, Jelle, Op de Beeck, Joyce, Uyttebroeck, Anne, Meijerink, Jules P. P., Moorman, Anthony V., Harrison, Christine J., Spincemaille, Pieter, Cools, Jan, Cassiman, David, Fendt, Sarah-Maria, Vermeersch, Pieter, De Keersmaecker, Kim

“…The R98S mutation in ribosomal protein L10 (RPL10 R98S) affects 8% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases, and was previously described…”
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HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia by O'Donohue, Marie-Françoise, Da Costa, Lydie, Lezzerini, Marco, Unal, Sule, Joret, Clément, Bartels, Marije, Brilstra, Eva, Scheijde-Vermeulen, Marijn, Wacheul, Ludivine, De Keersmaecker, Kim, Vereecke, Stijn, Labarque, Veerle, Saby, Manon, Lefevre, Sophie D., Platon, Jessica, Montel-Lehry, Nathalie, Laugero, Nathalie, Lacazette, Eric, van Gassen, Koen, Houtkooper, Riekelt H., Simsek-Kiper, Pelin Ozlem, Leblanc, Thierry, Yarali, Nese, Cetinkaya, Arda, Akarsu, Nurten A., Gleizes, Pierre-Emmanuel, Lafontaine, Denis L.J., MacInnes, Alyson W.

“…The congenital bone marrow failure syndrome Diamond-Blackfan anemia (DBA) is typically associated with variants in ribosomal protein (RP) genes impairing…”
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The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling by Girardi, T, Vereecke, S, Sulima, S O, Khan, Y, Fancello, L, Briggs, J W, Schwab, C, de Beeck, J Op, Verbeeck, J, Royaert, J, Geerdens, E, Vicente, C, Bornschein, S, Harrison, C J, Meijerink, J P, Cools, J, Dinman, J D, Kampen, K R, De Keersmaecker, K

“…Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the…”
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Abstract 1789: Repurposing the anti-depressant sertraline to target serine/glycine synthesis addicted cancer by Geeraerts, Shauni L., Kampen, Kim R., Rinaldi, Gianmarco, Gupta, Purvi, Planque, Mélanie, De Cremer, Kaat, De Brucker, Katrijn, Vereecke, Stijn, Verbelen, Benno, Vermeersch, Pieter, Cassiman, David, Fendt, Sarah-Maria, Voet, Arnout, Cammue, Bruno P.A., Thevissen, Karin, De Keersmaecker, Kim

“…Abstract Metabolic reprogramming is a well-established hallmark of cancer cells, which supports tumor growth, survival, and chemotherapy resistance. In this…”
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