Search Results - "Verdoes, M."

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells by Rückrich, T, Kraus, M, Gogel, J, Beck, A, Ovaa, H, Verdoes, M, Overkleeft, H S, Kalbacher, H, Driessen, C

“…Resistance towards the proteasome inhibitor bortezomib is poorly understood. We adapted the HL-60, ARH-77 and AMO-1 cell lines (myeloid leukemia, plasmocytoid…”
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Effect of Antigen Valency on Autoreactive B‑Cell Targeting by van Weijsten, M. J., Venrooij, K. R., Lelieveldt, L.P.W.M., Kissel, T., van Buijtenen, E., van Dalen, F. J., Verdoes, M., Toes, R.E.M., Bonger, K. M.

“…Many autoimmune diseases are characterized by B cells that mistakenly recognize autoantigens and produce antibodies toward self-proteins. Current therapies aim…”
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K by Mons, Elma, Jansen, Ineke D. C, Loboda, Jure, van Doodewaerd, Bjorn R, Hermans, Jill, Verdoes, Martijn, van Boeckel, Constant A. A, van Veelen, Peter A, Turk, Boris, Turk, Dusan, Ovaa, Huib

“…Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate…”
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Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib by Ovaa, Huib, Berkers, Celia R, Verdoes, Martijn, Lichtman, Eben, Fiebiger, Edda, Kessler, Benedikt M, Anderson, Kenneth C, Ploegh, Hidde L, Galardy, Paul J

“…Proteasome inhibitors, such as the dipeptide boronic acid bortezomib, are emerging as important tools in the treatment of the fatal hematologic malignancy…”
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An Unusual Reverse Turn Structure Adopted by a Furanoid Sugar Amino Acid Incorporated in Gramicidin S by Grotenbreg, Gijsbert M, Timmer, Mattie S. M, Llamas-Saiz, Antonio L, Verdoes, Martijn, van der Marel, Gijsbert A, van Raaij, Mark J, Overkleeft, Herman S, Overhand, Mark

“…A new reverse turn, replacing one of the native type II‘ β-turns in the cyclic peptide antibiotic gramicidin S, induced by a furanoid sugar amino acid is…”
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Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction by Timmer, Mattie S.M., Risseeuw, Martijn D.P., Verdoes, Martijn, Filippov, Dmitri V., Plaisier, Jasper R., van der Marel, Gijsbert A., Overkleeft, Herman S., van Boom, Jacques H.

“…[Display omitted] By combining a Staudinger/aza-Wittig and an Ugi three-component reaction in a one-pot process (SAWU-3CR), a new and efficient multicomponent…”
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A Practical Synthesis of Gramicidin S and Sugar Amino Acid Containing Analogues by Grotenbreg, Gijsbert M, Kronemeijer, Martijn, Timmer, Mattie S. M, El Oualid, Farid, van Well, Renate M, Verdoes, Martijn, Spalburg, Emile, van Hooft, Peter A. V, de Neeling, Albert J, Noort, Daan, van Boom, Jacques H, van der Marel, Gijsbert A, Overkleeft, Herman S, Overhand, Mark

“…A practical gram-scale and high-yielding synthesis of the antimicrobial peptide gramicidin S is presented. An Fmoc-based solid-phase peptide synthesis protocol…”
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The Use of a Mannitol-Derived Fused Oxacycle as a Combinatorial Scaffold by Timmer, Mattie S. M, Verdoes, Martijn, Sliedregt, Leo A. J. M, van der Marel, Gijsbert A, van Boom, Jacques H, Overkleeft, Herman S

“…An efficient and high-yielding solid-phase synthesis of a small library of compounds containing a cis-fused pyranofuran structural motive is descibed. With use…”
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A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo by Verdoes, Martijn, Florea, Bogdan I, Menendez-Benito, Victoria, Maynard, Christa J, Witte, Martin D, van der Linden, Wouter A, van den Nieuwendijk, Adrianus M C H, Hofmann, Tanja, Berkers, Celia R, van Leeuwen, Fijs W B, Groothuis, Tom A, Leeuwenburgh, Michiel A, Ovaa, Huib, Neefjes, Jacques J, Filippov, Dmitri V, van der Marel, Gijs A, Dantuma, Nico P, Overkleeft, Herman S

“…The proteasome is an essential evolutionary conserved protease involved in many regulatory systems. Here, we describe the synthesis and characterization of the…”
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