Search Results - "Verdeil, Grégory"

Regulatory circuits of T cell function in cancer by Speiser, Daniel E., Ho, Ping-Chih, Verdeil, Grégory

“…Key Points T cell dysfunction ('exhaustion') occurs in chronic infection and cancer Mechanisms of T cell dysfunction are partly disease specific and are partly…”
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Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment by Gomez-Cadena, Alejandra, Spehner, Laurie, Kroemer, Marie, Khelil, Myriam Ben, Bouiller, Kevin, Verdeil, Grégory, Trabanelli, Sara, Borg, Christophe, Loyon, Romain, Jandus, Camilla

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 disease pandemic. In some patients, the symptoms are mild,…”
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Tumor-Associated Macrophages in Bladder Cancer: Biological Role, Impact on Therapeutic Response and Perspectives for Immunotherapy by Leblond, Marine M., Zdimerova, Hana, Desponds, Emma, Verdeil, Grégory

“…Tumor-associated macrophages (TAMs) are one of the most abundant infiltrating immune cells of solid tumors. Despite their possible dual role, i.e., pro- or…”
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MAF drives CD8+ T-cell exhaustion by Verdeil, Grégory

“…The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8 + T cells…”
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tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells by Giordano, Marilyn, Roncagalli, Romain, Bourdely, Pierre, Chasson, Lionel, Buferne, Michel, Yamasaki, Sho, Beyaert, Rudi, van Loo, Geert, Auphan-Anezin, Nathalie, Schmitt-Verhulst, Anne-Marie, Verdeil, Grégory

“…The transcription factor NF-κB is central to inflammatory signaling and activation of innate and adaptive immune responses. Activation of the NF-κB pathway is…”
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LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures by Gestermann, Nicolas, Saugy, Damien, Martignier, Christophe, Tillé, Laure, Fuertes Marraco, Silvia A., Zettl, Markus, Tirapu, Iñigo, Speiser, Daniel E., Verdeil, Grégory

“…Despite the success of immunotherapy using checkpoint blockade, many patients with solid tumors remain refractory to these treatments. In human cancer, the…”
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Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion by Tillé, Laure, Cropp, Daniela, Charmoy, Mélanie, Reichenbach, Patrick, Andreatta, Massimo, Wyss, Tania, Bodley, Gabrielle, Crespo, Isaac, Nassiri, Sina, Lourenco, Joao, Leblond, Marine M., Lopez-Rodriguez, Cristina, Speiser, Daniel E., Coukos, George, Irving, Melita, Carmona, Santiago J., Held, Werner, Verdeil, Grégory

“…Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion…”
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More T Cells versus Better T Cells in Patients with Breast Cancer by Speiser, Daniel E, Verdeil, Grégory

“…Characterization of intratumoral leukocyte populations may help in estimating patients' prognosis and predictions. A new study shows remarkable differences…”
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Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion by Giordano, Marilyn, Henin, Coralie, Maurizio, Julien, Imbratta, Claire, Bourdely, Pierre, Buferne, Michel, Baitsch, Lukas, Vanhille, Laurent, Sieweke, Michael H, Speiser, Daniel E, Auphan-Anezin, Nathalie, Schmitt-Verhulst, Anne-Marie, Verdeil, Grégory

“…T cells infiltrating neoplasms express surface molecules typical of chronically virus‐stimulated T cells, often termed “exhausted” T cells. We compared the…”
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Maf deficiency in T cells dysregulates Treg - TH17 balance leading to spontaneous colitis by Imbratta, Claire, Leblond, Marine M., Bouzourène, Hanifa, Speiser, Daniel E., Velin, Dominique, Verdeil, Grégory

“…The maintenance of homeostasis in the gut is a major challenge for the immune system. Here we demonstrate that the transcription factor MAF plays a central…”
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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients by de Jonge, Kaat, Tillé, Laure, Lourenco, Joao, Maby-El Hajjami, Hélène, Nassiri, Sina, Racle, Julien, Gfeller, David, Delorenzi, Mauro, Verdeil, Grégory, Baumgaertner, Petra, Speiser, Daniel E.

“…The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6,…”
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From T cell “exhaustion” to anti-cancer immunity by Verdeil, Grégory, Fuertes Marraco, Silvia A., Murray, Timothy, Speiser, Daniel E.

“…The immune system has the potential to protect from malignant diseases for extended periods of time. Unfortunately, spontaneous immune responses are often…”
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Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density by Gilfillan, Connie B., Wang, Chensu, Mohsen, Mona O., Rufer, Nathalie, Hebeisen, Michael, Allard, Mathilde, Verdeil, Grégory, Irvine, Darrell J., Bachmann, Martin F., Speiser, Daniel E.

“…It is known that for achieving high affinity antibody responses, vaccines must be optimized for antigen dose/density, and the prime/boost interval should be at…”
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Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy by Verdeil, Grégory, Marquardt, Kristi, Surh, Charles D, Sherman, Linda A

“…Because of mechanisms of self-tolerance, many tumor-specific CD8 T cells exhibit low avidity for tumor antigens and would benefit from strategies that enhance…”
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Tumor microenvironment squeezes out the juice from T cells by Thouenon, Romane, Verdeil, Grégory

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Distinct patterns of cytolytic T‐cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization by Frick, Melissa, Mouchacca, Pierre, Verdeil, Grégory, Hamon, Yannick, Billaudeau, Cyrille, Buferne, Michel, Fallet, Mathieu, Auphan‐Anezin, Nathalie, Schmitt‐Verhulst, Anne‐Marie, Boyer, Claude

“…Summary Cancer‐germline genes in both humans and mice have been shown to encode antigens susceptible to targeting by cytotoxic CD8 T effector cells (CTL). We…”
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Unleashing antitumor T-cell activation without ensuing autoimmunity: the case for A20-deletion in adoptive CD8+ T-cell therapy by Verdeil, Grégory, Schmitt-Verhulst, Anne-Marie

“…Mechanisms controlling immune reactivity prevent excessive inflammation and autoimmunity, but generally dampen antitumor activity. We recently showed that…”
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c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes by Imbratta, Claire, Hussein, Hind, Andris, Fabienne, Verdeil, Grégory

“…Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of…”
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Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis by Trabanelli, Sara, Chevalier, Mathieu F., Martinez-Usatorre, Amaia, Gomez-Cadena, Alejandra, Salomé, Bérengère, Lecciso, Mariangela, Salvestrini, Valentina, Verdeil, Grégory, Racle, Julien, Papayannidis, Cristina, Morita, Hideaki, Pizzitola, Irene, Grandclément, Camille, Bohner, Perrine, Bruni, Elena, Girotra, Mukul, Pallavi, Rani, Falvo, Paolo, Leibundgut, Elisabeth Oppliger, Baerlocher, Gabriela M., Carlo-Stella, Carmelo, Taurino, Daniela, Santoro, Armando, Spinelli, Orietta, Rambaldi, Alessandro, Giarin, Emanuela, Basso, Giuseppe, Tresoldi, Cristina, Ciceri, Fabio, Gfeller, David, Akdis, Cezmi A., Mazzarella, Luca, Minucci, Saverio, Pelicci, Pier Giuseppe, Marcenaro, Emanuela, McKenzie, Andrew N. J., Vanhecke, Dominique, Coukos, George, Mavilio, Domenico, Curti, Antonio, Derré, Laurent, Jandus, Camilla

“…Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human…”
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Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies by Oster, Paul, Vaillant, Laurie, Riva, Erika, McMillan, Brynn, Begka, Christina, Truntzer, Caroline, Richard, Corentin, Leblond, Marine M, Messaoudene, Meriem, Machremi, Elisavet, Limagne, Emeric, Ghiringhelli, Francois, Routy, Bertrand, Verdeil, Gregory, Velin, Dominique

“…In this study, we determined whether ( ) infection dampens the efficacy of cancer immunotherapies. Using mouse models, we evaluated whether immune checkpoint…”
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