Search Results - "Vercauteren, Magali"
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Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation
Published in Scientific reports (21-07-2016)“…The biogenic amine serotonin (5-HT) is a multi-faceted hormone that is synthesized from dietary tryptophan with the rate limiting step being catalyzed by the…”
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Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B
Published in Journal of molecular and cellular cardiology (01-06-2012)“…Abstract Protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase receptor-mediated responses, and especially negatively influences insulin…”
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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension
Published in Journal of cardiovascular pharmacology (01-11-2015)“…AIMS:We compared the efficacy of macitentan, a novel dual endothelin A/endothelin B receptor antagonist, with that of another dual endothelin receptor…”
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Heart Rate Reduction Induced by the If Current Inhibitor Ivabradine Improves Diastolic Function and Attenuates Cardiac Tissue Hypoxia
Published in Journal of cardiovascular pharmacology (01-03-2012)“…AIMSEnhanced heart rate (HR) is a compensatory mechanism in chronic heart failure (CHF), preserving cardiac output, but at the cost of increased left…”
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Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure
Published in Circulation (New York, N.Y.) (05-12-2006)“…Chronic heart failure (CHF) induces endothelial dysfunction characterized by a decrease in nitric oxide (NO) production in response to flow (flow-mediated…”
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Assessment of Peripheral Serotonin Synthesis Using Stable Isotope‐Labeled Tryptophan
Published in Clinical pharmacology and therapeutics (01-12-2018)“…Serotonin (5‐HT) is synthesized from dietary tryptophan (Trp) and plays an important role in numerous diseases of the central nervous system and periphery…”
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Endothelin ET A Receptor Blockade, by Activating ET B Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention
Published in The Journal of pharmacology and experimental therapeutics (01-05-2017)“…Endothelin (ET) receptor antagonists have been associated with fluid retention. It has been suggested that, of the two endothelin receptor subtypes, ET…”
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Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone
Published in European heart journal (01-09-2008)“…Aims Inhibition of aldosterone synthase, the key enzyme in aldosterone formation, could be an alternative strategy for mineralocorticoid-receptor antagonists…”
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Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B
Published in Journal of molecular and cellular cardiology (01-06-2012)“…Protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase receptor-mediated responses, and especially negatively influences insulin sensitivity, thus…”
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Abstract 3552: Pharmacological Inhibition or Genetic Disruption of Protein Tyrosine Phosphatase 1B Attenuates both Myocardial and Endothelial Dysfunction in Mice with Heart Failure
Published in Circulation (New York, N.Y.) (28-10-2008)“…Abstract only We have shown previously that acute, in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) improved endothelial function of peripheral…”
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New pharmacological approaches in heart failure: should we treat the endothelium?
Published in Therapie (01-03-2009)“…Heart failure is associated with endothelial dysfunction, characterized especially by a decreased nitric oxide (NO) production. The main consequences of this…”
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