Search Results - "Verbeken, Mathieu"

Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine by Verbeken, Mathieu, Suleman, Sultan, Baert, Bram, Vangheluwe, Elien, Van Dorpe, Sylvia, Burvenich, Christian, Duchateau, Luc, Jansen, Frans H, De Spiegeleer, Bart

“…Lumefantrine (benflumetol) is a fluorene derivative belonging to the aryl amino alcohol class of anti-malarial drugs and is commercially available in fixed…”
Get full text

The influence of peptide impurity profiles on functional tissue–organ bath response: The 11-mer peptide INSL6[151–161] case by Verbeken, Mathieu, Wynendaele, Evelien, Lefebvre, Romain A., Goossens, Els, De Spiegeleer, Bart

“…Bioactive peptides have great pharmaceutical potential as nutraceuticals, diagnostics, and therapeutic drugs in several clinical areas. Thus, the search for…”
Get full text

Blood–brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins by Verbeken, Mathieu, Wynendaele, Evelien, Mauchauffée, Elodie, Bracke, Nathalie, Stalmans, Sofie, Bojnik, Engin, Benyhe, Sandor, Peremans, Kathelijne, Polis, Ingeborgh, Burvenich, Christian, Gjedde, Albert, Hernandez, Jean-François, De Spiegeleer, Bart

“…•Significantly higher BBB permeability for linear vs. cyclic enkephalin analogs.•Nanomolar μ-opioid receptor affinity for the four enkephalin…”
Get full text

Intrathecally injected Ile-Pro-Ile, an inhibitor of membrane ectoenzyme dipeptidyl peptidase IV, is antihyperalgesic in rats by switching the enzyme from hydrolase to synthase functional mode to generate endomorphin 2 by Király, Kornél, Szalay, Balázs, Szalai, Judit, Barna, István, Gyires, Klára, Verbeken, Mathieu, Rónai, András Z.

“…We have found recently that membrane-bound dipeptidyl peptidase IV (DPP-IV) generated extracellularly immunoreactive endomorphin-2 from Tyr-Pro precursor in a…”
Get full text

Development of peptide receptor binding assays: Methods to avoid false negatives by Vergote, Valentijn, Van Dorpe, Sylvia, Verbeken, Mathieu, Burvenich, Christian, Van de Wiele, Christophe, Banks, William A., De Spiegeleer, Bart

“…Selection of appropriate ligand receptor binding assay conditions is critical for peptides, where the possibility of obtaining false negative results is…”
Get full text