Search Results - "Verbeke, Stephanie"

Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Are Expressed in Breast Cancer and Can Be Targeted to Inhibit Tumor Cell Survival by VANHECKE, Elsa, ADRIAENSSENS, Eric, VERBEKE, Stéphanie, MEIGNAN, Samuel, GERMAIN, Emmanuelle, BERTEAUX, Nathalie, NURCOMBE, Victor, LE BOURHIS, Xuefen, HONDERMARCK, Hubert

“…Given that nerve growth factor has previously been shown to be involved in breast cancer progression, we have tested here the hypothesis that the other…”
Get full text

PLA2R1 Mediates Tumor Suppression by Activating JAK2 by VINDRIEUX, David, AUGERT, Arnaud, DE LAUNOIT, Yvan, LEROY, Xavier, PUISIEUX, Alain, AUBERT, Sébastien, PERRAIS, Michael, GELB, Michael, SIMONNET, Hélène, LAMBEAU, Gérard, BERNARD, David, GIRARD, Christophe A, GITENAY, Delphine, LALLET-DAHER, Helene, WIEL, Clotilde, LE CALVE, Benjamin, GRAS, Baptiste, FERRAND, Mylène, VERBEKE, Stéphanie

“…Little is known about the physiological role of the phospholipase A2 receptor (PLA2R1). PLA2R1 has been described as regulating the replicative senescence, a…”
Get full text

High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies by Toulmonde, Maud, Lucchesi, Carlo, Verbeke, Stéphanie, Crombe, Amandine, Adam, Julien, Geneste, Damien, Chaire, Vanessa, Laroche-Clary, Audrey, Perret, Raul, Bertucci, François, Bertolo, Frederic, Bianchini, Laurence, Dadone-Montaudie, Bérengère, Hembrough, Todd, Sweet, Steve, Kim, Yeoun Jin, Cecchi, Fabiola, Le Loarer, François, Italiano, Antoine

“…Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized sarcoma subtype. This study aims to assess UPS molecular…”
Get full text

Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation by LALLET-DAHER, Helene, WIEL, Clotilde, BERNARD, David, GITENAY, Delphine, NAVARATNAM, Naveenan, AUGERT, Arnaud, LE CALVE, Benjamin, VERBEKE, Stephanie, CARLING, David, AUBERT, Sebastien, VINDRIEUX, David

“…Oncogene-induced senescence (OIS) constitutes a failsafe program that restricts tumor development. However, the mechanisms that link oncogenesis to senescence…”
Get full text

Extracellular cleavage of the p75 neurotrophin receptor is implicated in its pro-survival effect in breast cancer cells by Verbeke, Stéphanie, Tomellini, Elisa, Dhamani, Fatima, Meignan, Samuel, Adriaenssens, Eric, Xuefen, Le Bourhis

“…•The p75 neurotrophin receptor (p75NTR) undergoes sequential proteolytic cleavages in MDA-MB-231breast cancer cells.•The carboxyl-terminal fragment…”
Get full text

Overexpression of p75(NTR) increases survival of breast cancer cells through p21(waf1) by Verbeke, Stéphanie, Meignan, Samuel, Lagadec, Chann, Germain, Emmanuelle, Hondermarck, Hubert, Adriaenssens, Eric, Le Bourhis, Xuefen

“…The p75 neurotrophin receptor (p75(NTR)) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation and…”
Get full text

Antitumor Effects of PRMT5 Inhibition in Sarcomas by Verbeke, Stéphanie, Bourdon, Aurélien, Guegan, Jean-Philippe, Leroy, Laura, Chaire, Vanessa, Richard, Elodie, Bessede, Alban, Italiano, Antoine

“…Abstract Patients with advanced soft-tissue sarcomas (STS) have few therapeutic options. Protein arginine methyltransferase 5 (PRMT5), an anticancer target,…”
Get full text

ATR Inhibition Broadly Sensitizes Soft-Tissue Sarcoma Cells to Chemotherapy Independent of Alternative Lengthening Telomere (ALT) Status by Laroche-Clary, Audrey, Chaire, Vanessa, Verbeke, Stéphanie, Algéo, Marie-Paule, Malykh, Andrei, Le Loarer, François, Italiano, Antoine

“…Only few drugs have shown activity in patients with advanced soft-tissue and the median overall survival is only 18 months. Alterations of genes involved in…”
Get full text

MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies by Roy, Shomereeta, Laroche-Clary, Audrey, Verbeke, Stephanie, Derieppe, Marie-Alix, Italiano, Antoine

“…The MDM2 gene is amplified in dedifferentiated liposarcoma (DDLPS). Treatment with MDM2 antagonists is a promising strategy to treat DDLPS; however, drug…”
Get full text

Abstract 1844: Anti-tumor activity of a dual BET/CBP/EP300 inhibitor, NEO2734, in undifferentiated pleomorphic sarcomas and identification of genes involved in resistance by Verbeke, Stephanie, Bertolo, Frederic, Chaire, Vanessa, Bourdon, Aurelien, Eldjoudi, Amina Naït, Derieppe, Marie-Alix, Giles, Francis, Italiano, Antoine

“…Abstract Introduction: Undifferentiated pleomorphic sarcoma is the most frequent and the most aggressive sarcoma subtype. Despite adequate locoregional…”
Get full text

Abstract 3937: PRMT5 inhibition suppress soft tissue sarcomas tumorigenicity through the regulation of glucose metabolism by Verbeke, Stephanie, Leroy, Laura, Bourdon, Aurelien, Chaire, Vanessa, Richard, Elodie, Guegan, Jean-Philippe, Bessede, Alban, Italiano, Antoine

“…Abstract Introduction: Soft tissue sarcomas (STS) are a heterogeneous group of rare tumors representing 1% of solid tumors in adults and 15% in children…”
Get full text

Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells by Verbeke, Stephanie, Richard, Elodie, Monceau, Elodie, Schmidt, Xenia, Rousseau, Benoit, Velasco, Valerie, Bernard, David, Bonnefoi, Herve, MacGrogan, Gaetan, Iggo, Richard D

“…The cell of origin for estrogen receptor α-positive (ERα+) breast cancer is probably a luminal stem cell in the terminal duct lobular units. To model these…”
Get full text

Overexpression of p75NTR increases survival of breast cancer cells through p21waf1 by Verbeke, Stéphanie, Meignan, Samuel, Lagadec, Chann, Germain, Emmanuelle, Hondermarck, Hubert, Adriaenssens, Eric, Le Bourhis, Xuefen

Get full text

Erratum to: Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells by Verbeke, Stephanie, Richard, Elodie, Monceau, Elodie, Schmidt, Xenia, Rousseau, Benoit, Velasco, Valerie, Bernard, David, Bonnefoi, Herve, MacGrogan, Gaetan, Iggo, Richard D

“…Due to a typesetting error, the labelling was changed and the figures in this article [1] were presented in the order 2, 4, 10, 6, 1, 3, 5, 7, 8, 9, 11, 12,…”
Get full text

Overexpression of p75 super(NTR) increases survival of breast cancer cells through p21 super(waf1) by Verbeke, Stephanie, Meignan, Samuel, Lagadec, Chann, Germain, Emmanuelle, Hondermarck, Hubert, Adriaenssens, Eric, Van Bourhis, Xuefen

“…The p75 neurotrophin receptor (p75 super(NTR)) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival,…”
Get full text

Antigen-specific immune modulation using an injectable biomaterial by Verbeke, Catia Stephanie

“…The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies…”
Get full text

Overexpression of p75 NTR increases survival of breast cancer cells through p21 waf1 by Verbeke, Stéphanie, Meignan, Samuel, Lagadec, Chann, Germain, Emmanuelle, Hondermarck, Hubert, Adriaenssens, Eric, Le Bourhis, Xuefen

“…The p75 neurotrophin receptor (p75 NTR) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation and…”
Get full text