Search Results - "Verbeke, Rein"

The dawn of mRNA vaccines: The COVID-19 case by Verbeke, Rein, Lentacker, Ine, De Smedt, Stefaan C., Dewitte, Heleen

“…In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based vaccines, BNT162b2 and mRNA-1273, were granted the first historic…”
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mRNA in cancer immunotherapy: beyond a source of antigen by Van Hoecke, Lien, Verbeke, Rein, Dewitte, Heleen, Lentacker, Ine, Vermaelen, Karim, Breckpot, Karine, Van Lint, Sandra

“…mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the…”
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Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria by Meulewaeter, Sofie, Aernout, Ilke, Deprez, Joke, Engelen, Yanou, De Velder, Margo, Franceschini, Lorenzo, Breckpot, Karine, Van Calenbergh, Serge, Asselman, Caroline, Boucher, Katie, Impens, Francis, De Smedt, Stefaan C., Verbeke, Rein, Lentacker, Ine

“…Although various types of mRNA-based vaccines have been explored, the optimal conditions for induction of both humoral and cellular immunity remain rather…”
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Exciting Times for Lipid Nanoparticles: How Canadian Discoveries Are Enabling Gene Therapies by Cheng, Miffy H. Y., Brimacombe, Cedric A., Verbeke, Rein, Cullis, Pieter R.

“…In this brief perspective, we describe key events in the history of the lipid-based nanomedicine field, highlight Canadian contributions, and outline areas…”
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Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes by Mayer, Rupert L., Verbeke, Rein, Asselman, Caroline, Aernout, Ilke, Gul, Adillah, Eggermont, Denzel, Boucher, Katie, Thery, Fabien, Maia, Teresa M., Demol, Hans, Gabriels, Ralf, Martens, Lennart, Bécavin, Christophe, De Smedt, Stefaan C., Vandekerckhove, Bart, Lentacker, Ine, Impens, Francis

“…Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic…”
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Intracellular Delivery of mRNA in Adherent and Suspension Cells by Vapor Nanobubble Photoporation by Raes, Laurens, Stremersch, Stephan, Fraire, Juan C., Brans, Toon, Goetgeluk, Glenn, De Munter, Stijn, Van Hoecke, Lien, Verbeke, Rein, Van Hoeck, Jelter, Xiong, Ranhua, Saelens, Xavier, Vandekerckhove, Bart, De Smedt, Stefaan, Raemdonck, Koen, Braeckmans, Kevin

“…Highlights Vapor nanobubble (VNB) photoporation represents a promising physical technique for mRNA transfection of adherent and suspension cells. A multitude…”
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Fluorine MR Imaging Probes Dynamic Migratory Profiles of Perfluorocarbon-Loaded Dendritic Cells After Streptozotocin-Induced Inflammation by Saini, Shweta, Vanherwegen, An-Sofie, Liang, Sayuan, Verbeke, Rein, Korf, Hannelie, Lentacker, Ine, De Smedt, Stefaan C., Gysemans, Conny, Himmelreich, Uwe

“…Purpose The pathogenesis of type 1 diabetes (T1D) involves presentation of islet-specific self-antigens by dendritic cells (DCs) to autoreactive T cells,…”
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Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon by Broos, Katrijn, Van der Jeught, Kevin, Puttemans, Janik, Goyvaerts, Cleo, Heirman, Carlo, Dewitte, Heleen, Verbeke, Rein, Lentacker, Ine, Thielemans, Kris, Breckpot, Karine

“…Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated research into carriers that can protect it from ribonucleases…”
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mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice by Van Hoecke, Lien, Verbeke, Rein, De Vlieger, Dorien, Dewitte, Heleen, Roose, Kenny, Van Nevel, Sharon, Krysko, Olga, Bachert, Claus, Schepens, Bert, Lentacker, Ine, Saelens, Xavier

“…To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past…”
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Longitudinal In Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis by Saini, Shweta, Poelmans, Jennifer, Korf, Hannelie, Dooley, James L., Liang, Sayuan, Manshian, Bella B., Verbeke, Rein, Soenen, Stefaan J., Vande Velde, Greetje, Lentacker, Ine, Lagrou, Katrien, Liston, Adrian, Gysemans, Conny, De Smedt, Stefaan C., Himmelreich, Uwe

“…The fungus Aspergillus fumigatus is ubiquitous in nature and the most common cause of invasive pulmonary aspergillosis (IPA) in patients with a compromised…”
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Three decades of messenger RNA vaccine development by Verbeke, Rein, Lentacker, Ine, De Smedt, Stefaan C., Dewitte, Heleen

“…[Display omitted] •mRNA represents an attractive source of antigen in vaccination approaches.•Both unformulated and nanoparticulate mRNA are used for direct in…”
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mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability by Schoenmaker, Linde, Witzigmann, Dominik, Kulkarni, Jayesh A., Verbeke, Rein, Kersten, Gideon, Jiskoot, Wim, Crommelin, Daan J.A.

“…[Display omitted] •The current COVID-19 mRNA-LNPs vaccines must be stored at (ultra)low temperatures.•The core of LNPs contains mRNA, an ionizable cationic…”
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Innate immune mechanisms of mRNA vaccines by Verbeke, Rein, Hogan, Michael J., Loré, Karin, Pardi, Norbert

“…The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been used to generate safe and effective vaccines in record time against…”
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Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA by Verbeke, Rein, Lentacker, Ine, Wayteck, Laura, Breckpot, Karine, Van Bockstal, Mieke, Descamps, Benedicte, Vanhove, Christian, De Smedt, Stefaan C., Dewitte, Heleen

“…This study reports on the design of mRNA and adjuvant-loaded lipid nanoparticles for therapeutic cancer vaccination. The use of nucleoside-modified mRNA has…”
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Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α‑GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells by Verbeke, Rein, Lentacker, Ine, Breckpot, Karine, Janssens, Jonas, Van Calenbergh, Serge, De Smedt, Stefaan C, Dewitte, Heleen

“…Messenger RNA encoding tumor antigens has the potential to evoke effective antitumor immunity. This study reports on a nanoparticle platform, named mRNA…”
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Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across by Minnaert, An-Katrien, Vanluchene, Helena, Verbeke, Rein, Lentacker, Ine, De Smedt, Stefaan C., Raemdonck, Koen, Sanders, Niek N., Remaut, Katrien

“…[Display omitted] The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional…”
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Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures by Meulewaeter, Sofie, Nuytten, Gust, Cheng, Miffy H.Y., De Smedt, Stefaan C., Cullis, Pieter R., De Beer, Thomas, Lentacker, Ine, Verbeke, Rein

“…Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA…”
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Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment by Dewitte, Heleen, Verbeke, Rein, Breckpot, Karine, De Smedt, Stefaan C., Lentacker, Ine

“…•Adjuvanted particulate vaccines for dendritic cell targeting in vivo are on the rise.•Tumor-mediated immune suppression is a major hurdle in…”
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Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium by Deprez, Joke, Verbeke, Rein, Meulewaeter, Sofie, Aernout, Ilke, Dewitte, Heleen, Decruy, Tine, Coudenys, Julie, Van Duyse, Julie, Van Isterdael, Gert, Peer, Dan, van der Meel, Roy, De Smedt, Stefaan C., Jacques, Peggy, Elewaut, Dirk, Lentacker, Ine

“…The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well documented. Liposomes are believed to largely transport drugs into…”
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Considerations on the design of lipid-based mRNA vaccines against cancer by Meulewaeter, Sofie, Zhang, Yao, Wadhwa, Abishek, Fox, Kevin, Lentacker, Ine, Harder, Kenneth W, Cullis, Pieter R, De Smedt, Stefaan C, H Y Cheng, Miffy, Verbeke, Rein

“…Throughout the last decades, mRNA vaccines have been developed as a cancer immunotherapeutic and the technology recently gained momentum during the COVID-19…”
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