Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier

•Acetylated cashew gum was successfully synthesized.•Self-assembled nanoparticles were produced by the dialysis method.•Spherical nanoparticle with unimodal particle size distributions were observed.•Controlled indomethacin release was observed for up to 72h. Acetylated cashew gum (ACG) was synthesi...

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Bibliographic Details
Published in:	Carbohydrate polymers Vol. 117; pp. 610 - 615
Main Authors:	Pitombeira, Nadia A.O., Veras Neto, José Guilherme, Silva, Durcilene A., Feitosa, Judith P.A., Paula, Haroldo C.B., de Paula, Regina C.M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 06-03-2015
Subjects:	Acetylation Anacardium - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug release Hydrophobic cashew gum Hydrophobic polysaccharide Indomethacin Nanoparticle Nanoparticles - chemistry Plant Gums - chemical synthesis Plant Gums - chemistry Hydrophobic cashew gum Drug release Hydrophobic polysaccharide Indomethacin (CID: 3715) Nanoparticle Formamide (CID: 713) Dimethyl sulfoxide (CID: 679) Pyridine (CID: 1049) Acetic anhydride (CID: 7918) Acetylation Indomethacin
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Summary:	•Acetylated cashew gum was successfully synthesized.•Self-assembled nanoparticles were produced by the dialysis method.•Spherical nanoparticle with unimodal particle size distributions were observed.•Controlled indomethacin release was observed for up to 72h. Acetylated cashew gum (ACG) was synthesized and self-assembled nanoparticles were obtained through the dialysis of an organic solution (DMSO) against a non-solvent (water). The ACG was characterized by infrared spectroscopy. The degree of substitution was 2.8 as determined by NMR spectroscopy. The physicochemical properties of the self-assembled nanoparticles in aqueous media were characterized by DLS, SEM and fluorescence spectroscopy. The mean diameter of the self-assembled nanoparticles obtained was 179nm and the critical aggregation concentration (CAC) in water was 2.1×10−3g/L. Indomethacin (IND) was used as a hydrophobic model drug and was incorporated into the hydrophobized polysaccharide. Both loaded and unloaded nanoparticles were found to be spherical with diameters in the ranges of 70–170nm and 108–314nm (determined by SEM), respectively. Controlled drug release was observed for up to 72h.
ISSN:	0144-8617 1879-1344
DOI:	10.1016/j.carbpol.2014.09.087