Search Results - "Veras, Matthew A"
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Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis
Published in Nature communications (08-05-2023)“…Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae become fused through formation of osteophytes. The genetic and…”
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Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis
Published in Arthritis research & therapy (29-04-2023)“…Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of calcification on pain…”
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Plasma and Kidney Proteome Profiling Combined with Laser Capture Microdissection Reveal Large Increases in Immunoglobulins with Age
Published in Proteomes (03-06-2024)“…One of the main hallmarks of aging is aging-associated inflammation, also known as inflammaging. In this study, by comparing plasma and kidney proteome…”
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Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences
Published in JOR-spine (01-12-2023)“…Background Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no…”
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Protocol for parallel proteomic and metabolomic analysis of mouse intervertebral disc tissues
Published in JOR-spine (01-09-2020)“…The comprehensiveness of data collected by “omics” modalities has demonstrated the ability to drastically transform our understanding of the molecular…”
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Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction
Published in Seminars in cell & developmental biology (01-02-2017)“…Back pain is the most common cause of pain and disability worldwide. While its etiology remains unknown, it is typically associated with intervertebral disc…”
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Whole-body vibration of mice induces progressive degeneration of intervertebral discs associated with increased expression of IL-1β and multiple matrix degrading enzymes
Published in Osteoarthritis and cartilage (01-05-2017)“…Summary Objective Whole-body vibration (WBV) is a popular fitness trend based on claims of increased muscle mass, weight-loss and reduced joint pain. Following…”
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Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc
Published in Journal of cellular physiology (01-08-2019)“…Mice lacking equilibrative nucleoside transporter 1 (ENT1 −/−) demonstrate progressive calcification of spinal tissues including the annulus fibrosus (AF) of…”
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Journal Article -
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Regulators of Ectopic Calcification in a Mouse Model of Dish: A Multi-Omics Perspective
Published 01-01-2020“…Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy and the second most common form of arthritis characterized by…”
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Dissertation