Search Results - "Verardi, Paulo H."

Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice by Jasperse, Brittany, O’Connell, Caitlin M., Wang, Yuxiang, Verardi, Paulo H.

“…Zika virus (ZIKV), a flavivirus transmitted primarily by infected mosquitos, can cause neurological symptoms such as Guillian–Barré syndrome and microcephaly…”
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Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus by Herman, Julianna, Rittenhouse, Nicole, Mandino, Francesca, Majid, Mushirah, Wang, Yuxiang, Mezger, Amelia, Kump, Aidan, Kadian, Sumeet, Lake, Evelyn M R, Verardi, Paulo H, Conover, Joanne C

“…Congenital post-infectious hydrocephalus (PIH) is a condition characterized by enlargement of the ventricular system, consequently imposing a burden on the…”
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Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes by Cervantes, Jorge L., La Vake, Carson J., Weinerman, Bennett, Luu, Stephanie, OˈConnell, Caitlin, Verardi, Paulo H., Salazar, Juan C.

“…Spirochetal RNA is the ligand for human TLR8; activation of this receptor occurs within the phagosome. Phagocytosed Borrelia burgdorferi (Bb), the Lyme disease…”
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Replication-inducible vaccinia virus vectors with enhanced safety in vivo by O'Connell, Caitlin M, Jasperse, Brittany, Hagen, Caitlin J, Titong, Allison, Verardi, Paulo H

“…Vaccinia virus (VACV) has been used extensively as the vaccine against smallpox and as a viral vector for the development of recombinant vaccines and cancer…”
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A PRRSV GP5-Mosaic vaccine: Protection of pigs from challenge and ex vivo detection of IFNγ responses against several genotype 2 strains by Cui, Junru, O'Connell, Caitlin M, Costa, Antonio, Pan, Yan, Smyth, Joan A, Verardi, Paulo H, Burgess, Diane J, Van Kruiningen, Herbert J, Garmendia, Antonio E

“…Porcine reproductive and respiratory syndrome virus (PRRSV), is a highly mutable RNA virus that affects swine worldwide and its control is very challenging due…”
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Generation of Multiple Arbovirus-like Particles Using a Rapid Recombinant Vaccinia Virus Expression Platform by Wang, Yuxiang, Griffiths, Anthony, Brackney, Douglas E, Verardi, Paulo H

“…As demonstrated by the 2015 Zika virus outbreak in the Americas, emerging and re-emerging arboviruses are public health threats that warrant research…”
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Correction: A PRRSV GP5-Mosaic vaccine: Protection of pigs from challenge and ex vivo detection of IFNγ responses against several genotype 2 strains by Cui, Junru, O'Connell, Caitlin M, Costa, Antonio, Pan, Yan, Smyth, Joan A, Verardi, Paulo H, Burgess, Diane J, Van Kruiningen, Herbert J, Garmendia, Antonio E

“…[This corrects the article DOI: 10.1371/journal.pone.0208801.]…”
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A vaccinia virus renaissance: New vaccine and immunotherapeutic uses after smallpox eradication by Verardi, Paulo H., Titong, Allison, Hagen, Caitlin J.

“…In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective…”
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EPPIC (Efficient Purification by Parental Inducer Constraint) Platform for Rapid Generation of Recombinant Vaccinia Viruses by Jasperse, Brittany, O’Connell, Caitlin M., Wang, Yuxiang, Verardi, Paulo H.

“…Vaccinia virus (VACV) was successfully used as a vaccine in the smallpox eradication campaign. Since then, it has been widely used in the development of…”
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Safety mechanism assisted by the repressor of tetracycline (SMART) vaccinia virus vectors for vaccines and therapeutics by Grigg, Patricia, Titong, Allison, Jones, Leslie A., Yilma, Tilahun D., Verardi, Paulo H.

“…Replication-competent viruses, such as Vaccinia virus (VACV), are powerful tools for the development of oncolytic viral therapies and elicit superior immune…”
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Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice by Papin, James F, Verardi, Paulo H, Jones, Leslie A, Monge-Navarro, Francisco, Brault, Aaron C, Holbrook, Michael R, Worthy, Melissa N, Freiberg, Alexander N, Yilma, Tilahun D

“…Rift Valley fever (RVF) is a zoonotic disease endemic in Africa and the Arabian Peninsula caused by the highly infectious Rift Valley fever virus (RVFV) that…”
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Broad Protection of Pigs against Heterologous PRRSV Strains by a GP5-Mosaic DNA Vaccine Prime/GP5-Mosaic rVaccinia (VACV) Vaccine Boost by Cui, Junru, O'Connell, Caitlin M, Hagen, Connor, Sawicki, Kim, Smyth, Joan A, Verardi, Paulo H, Kruiningen, Herbert J Van, Garmendia, Antonio E

“…Porcine reproductive and respiratory syndrome (PRRS) viruses are a major cause of disease and economic loss in pigs worldwide. High genetic diversity among…”
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Modeling coronavirus spike protein dynamics: implications for immunogenicity and immune escape by Kunkel, Genevieve, Madani, Mohammad, White, Simon J., Verardi, Paulo H., Tarakanova, Anna

“…The ongoing COVID-19 pandemic is a global public health emergency requiring urgent development of efficacious vaccines. While concentrated research efforts…”
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Use of a recombinant vaccinia virus expressing interferon gamma for post-exposure protection against vaccinia and ectromelia viruses by Holechek, Susan A, Denzler, Karen L, Heck, Michael C, Schriewer, Jill, Buller, R Mark, Legrand, Fatema A, Verardi, Paulo H, Jones, Leslie A, Yilma, Tilahun, Jacobs, Bertram L

“…Post-exposure vaccination with vaccinia virus (VACV) has been suggested to be effective in minimizing death if administered within four days of smallpox…”
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Incorporation of CD40 Ligand into the Envelope of Pseudotyped Single-Cycle Simian Immunodeficiency Viruses Enhances Immunogenicity by LIN, Fan-Ching, YUE PENG, JONES, Leslie A, VERARDI, Paulo H, YILMA, Tilahun D

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Induction of Potent Humoral and Cell-Mediated Immune Responses by Attenuated Vaccinia Virus Vectors with Deleted Serpin Genes by LEGRAND, Fatema A, VERARDI, Paulo H, JONES, Leslie A, CHAN, Kenneth S, YUE PENG, YILMA, Tilahun D

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Lower Levels of Gamma Interferon Expressed by a Pseudotyped Single-Cycle Simian Immunodeficiency Virus Enhance Immunogenicity in Rats by YUE PENG, LIN, Fan-Ching, VERARDI, Paulo H, JONES, Leslie A, YILMA, Tilahun D

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Vaccinia Viruses with a Serpin Gene Deletion and Expressing IFN-γ Induce Potent Immune Responses without Detectable Replication in vivo by Legrand, Fatema A., Verardi, Paulo H., Chan, Kenneth S., Peng, Yue, Jones, Leslie A., Yilma, Tilahun D.

“…In a continuing effort to develop safe and efficacious vaccine and immunotherapeutic vectors, we constructed recombinant vaccinia virus (rVV) vaccines lacking…”
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Pseudotyped Single-Cycle Simian Immunodeficiency Viruses Expressing Gamma Interferon Augment T-Cell Priming Responses In Vitro by YUE PENG, LIN, Fan-Ching, VERARDI, Paulo H, JONES, Leslie A, MCCHESNEY, Michael B, YILMA, Tilahun D

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Antibiotic-dependent expression of early transcription factor subunits leads to stringent control of vaccinia virus replication by Hagen, Caitlin J., Titong, Allison, Sarnoski, Ethan A., Verardi, Paulo H.

“…•Uncontrolled replication of vaccinia virus vectors can lead to complications.•We placed early transcription factor genes under the control of tet operon…”
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