Photo-induced protein modifications: a range of biological consequences and applications

Proteins are the most abundant biomolecules in living organisms and tissues and are also present in many natural and processed foods and beverages, as well as in pharmaceuticals and therapeutics. When exposed to UV–visible light, proteins containing endogenous or exogenous chromophores can undergo d...

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Bibliographic Details
Published in:	Biophysical reviews Vol. 15; no. 4; pp. 569 - 576
Main Authors:	Vera, Claudia Cecilia, Borsarelli, Claudio Darío
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2023 Springer Nature B.V
Subjects:	Beverages Biochemistry Biological and Medical Physics Biological Techniques Biomaterials Biomedical and Life Sciences Biomedical materials Biomolecules Biophysics Biosensors Catalysis Cell Biology Cell death Chromophores Crosslinking Food processing Life Sciences Membrane Biology Nanotechnology Oxidation Photodynamic therapy Proteins Proteolysis Review Wound healing Photosensitization Protein photochemistry Photocrosslinking Photooxidation Photobonding
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Summary:	Proteins are the most abundant biomolecules in living organisms and tissues and are also present in many natural and processed foods and beverages, as well as in pharmaceuticals and therapeutics. When exposed to UV–visible light, proteins containing endogenous or exogenous chromophores can undergo direct and indirect photochemical processes, resulting in protein modifications including oxidation of residues, cross-linking, proteolysis, covalent binding to molecules and interfaces, and conformational changes. When these modifications occur in an uncontrolled manner in a physiological context, they can lead to biological dysfunctions that ultimately result in cell death. However, rational design strategies involving light-activated protein modification have proven to be a valuable tool for the modulation of protein function or even for the construction of new biomaterials. This mini-review describes the fundamentals of photochemical processes in proteins and explores some of their emerging biomedical and nanobiotechnological applications, such as photodynamic therapy (PDT), photobonding for wound healing, photobioprinting, photoimmobilization of biosensors and enzymes for sensing, and biocatalysis, among others.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1867-2450 1867-2469
DOI:	10.1007/s12551-023-01081-6