Search Results - "Verônica Schmitz"

Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions by da Silva, Camila Oliveira, Dias, André Alves, da Costa Nery, José Augusto, de Miranda Machado, Alice, Ferreira, Helen, Rodrigues, Thais Fernanda, Sousa Santos, João Pedro, Nadaes, Natalia Rocha, Sarno, Euzenir Nunes, Saraiva, Elvira Maria, Schmitz, Verônica, Pessolani, Maria Cristina Vidal

“…Up to 50% of patients with the multibacillary form of leprosy are expected to develop acute systemic inflammatory episodes known as type 2 reactions (T2R),…”
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CD163 favors Mycobacterium leprae survival and persistence by promoting anti‐inflammatory pathways in lepromatous macrophages by Moura, Danielle F., de Mattos, Katherine A., Amadeu, Thaís P., Andrade, Priscila R., Sales, Jorgenilce S., Schmitz, Verônica, Nery, José Augusto C., Pinheiro, Roberta O., Sarno, Euzenir N.

“…Lepromatous macrophages possess a regulatory phenotype that contributes to the immunosuppression observed in leprosy. CD163, a scavenger receptor that…”
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Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi by Monteiro, Ana Carolina, Schmitz, Veronica, Svensjo, Erik, Gazzinelli, Ricardo T, Almeida, Igor C, Todorov, Alex, de Arruda, Luciana B, Torrecilhas, Ana Claudia T, Pesquero, Joao B, Morrot, Alexandre, Bouskela, Eliete, Bonomo, Adriana, Lima, Ana Paula C. A, Muller-Esterl, Werner, Scharfstein, Julio

“…We have previously reported that exogenous bradykinin activates immature dendritic cells (DCs) via the bradykinin B(2) receptor (B(2)R), thereby stimulating…”
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AVALIAÇÃO DO EFEITO DO COVID-19 SOBRE AS REAÇÕES HANSÊNICAS EM PESSOAS ACOMETIDAS POR HANSENÍASE by da Fonseca, Marayah Sampaio Ruas, Sales, Anna Maria, Pereira, Verônica Schmitz, Illarramendi, Ximena

“…A hanseníase (MH) é doença infecciosa crônica envolvendo nervos e pele e o curso clínico pode ser complicado por episódios imunoinflamatórios chamados reações,…”
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Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses by Monteiro, Ana Carolina, Schmitz, Verônica, Morrot, Alexandre, de Arruda, Luciana Barros, Nagajyothi, Fnu, Granato, Alessandra, Pesquero, João B, Müller-Esterl, Werner, Tanowitz, Herbert B, Scharfstein, Julio

“…Although the concept that dendritic cells (DCs) recognize pathogens through the engagement of Toll-like receptors is widely accepted, we recently suggested…”
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COVID-19, leprosy, and neutrophils by Schmitz, Veronica, Dos Santos, Jéssica Brandão

“…Coronavirus Disease 2019 (COVID-19), a disease caused by the betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has only recently…”
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Innate Immune Responses in Leprosy by Pinheiro, Roberta Olmo, Schmitz, Veronica, Silva, Bruno Jorge de Andrade, Dias, André Alves, de Souza, Beatriz Junqueira, de Mattos Barbosa, Mayara Garcia, de Almeida Esquenazi, Danuza, Pessolani, Maria Cristina Vidal, Sarno, Euzenir Nunes

“…Leprosy is an infectious disease that may present different clinical forms depending on host immune response to . Several studies have clarified the role of…”
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Editorial: Strategies Played by Immune Cells and Mycobacteria in the Battle Between Antimicrobial Activity and Bacterial Survival by Schmitz, Veronica, Jo, Eun-Kyeong, Ochoa, Maria Teresa, Teles, Rosane M B

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Neutrophilic leukocytosis and erythema nodosum leprosum in leprosy: insights from a retrospective observational study by Feitosa da Silva Barboza, Marcella, de Andrea Hacker, Mariana, Maria Sales, Anna, Fontoura Rodrigues, Débora, Pedrosa Marques, Daniel, José Ciryllo Silva Noya, Danillo, Leal Silveira Andrezo Rosa, Thabatta, de Fátima Alvim Braga, Isabel, Ferreira, Helen, Porto Amadeu, Thais, Gurgel de Oliveira, Monique, de Miranda Machado, Alice, Illarramendi, Ximena, Schmitz, Veronica

“…Leprosy reactions represent immunologically mediated episodes of acute inflammation that, if not diagnosed and treated promptly, can cause irreversible…”
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Neutrophils in Leprosy by Schmitz, Veronica, Tavares, Isabella Forasteiro, Pignataro, Patricia, Machado, Alice de Miranda, Pacheco, Fabiana Dos Santos, Dos Santos, Jéssica Brandão, da Silva, Camila Oliveira, Sarno, Euzenir Nunes

“…Leprosy is an infectious disease caused by the intracellular bacillus that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of…”
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Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction by Rosa, Thabatta Leal Silveira Andrezo, Leal-Calvo, Thyago, Tavares, Isabella Forasteiro, Mendes, Mayara Abud, Dias, André Alves, Piauy, Meire Hellen Dos Santos, Barboza, Marcella Feitosa da Silva, Kapuscinski, Marylee, Costa, Fabrício da Mota Ramalho, Marques, Maria Angela M, Belone, Andrea de Faria F, Sales, Anna Maria, Hacker, Mariana de Andrea, Moreira, Marcia de Berredo Pinho, Belisle, John T, Moraes, Milton Ozório, Pessolani, Maria Cristina Vidal, Schmitz, Veronica

“…Patients with the multibacillary form of leprosy can develop reactional episodes of acute inflammation, known as erythema nodosum leprosum (ENL), which are…”
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New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] by de Macedo, Cristiana Santos, Lara, Flavio Alves, Pinheiro, Roberta Olmo, Schmitz, Veronica, de Berrêdo-Pinho, Marcia, Pereira, Geraldo Moura, Pessolani, Maria Cristina Vidal

“…Chronic infection by the obligate intracellular pathogen Mycobacterium leprae may lead to the development of leprosy. Of note, in the lepromatous clinical form…”
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Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases by Yong, Vladimir, Schmitz, Verônica, Vannier-Santos, Marcos André, de A. Lima, Ana Paula C, Lalmanach, Gilles, Juliano, Luiz, Gauthier, Francis, Scharfstein, Julio

“…The therapeutic potential of synthetic inhibitors to the major cysteine-proteinase from Trypanosoma cruzi (cruzain or cruzipain) was recently demonstrated in…”
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Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease by Corrêa, Raquel da Silva, Rodrigues, Luciana Silva, Pereira, Leticia Hagge Lima, Nogueira, Otto Castro, Leung, Janaína, Sousa, Marcela da S, Hacker, Mariana de Andrea, Siqueira, Helio Ribeiro de, Capone, Domênico, Alves, Rogério Lopes Rufino, Pessolani, Maria Cristina Vidal, Schmitz, Veronica, Pereira, Geraldo Moura Batista

“…CD64 (FcγR1) is a high-affinity receptor for monomeric IgG1 and IgG3. Circulating neutrophils express very low amounts of CD64 on their surface. Our primary…”
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AVALIAÇÃO DO EFEITO DO COVID-19 SOBRE AS REAÇÕES HANSÊNICAS EM PESSOAS ACOMETIDAS POR HANSENÍASE by da Fonseca, Marayah Sampaio Ruas, Sales, Anna Maria, Pereira, Verônica Schmitz, Illarramendi, Ximena

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Mycobacterium leprae Induces Neutrophilic Degranulation and Low-Density Neutrophil Generation During Erythema Nodosum Leprosum by Tavares, Isabella Forasteiro, dos Santos, Jessica Brandão, Pacheco, Fabiana dos Santos, Gandini, Mariana, Mariante, Rafael M., Rodrigues, Thais Fernanda, Sales, Anna Maria, Moraes, Milton Ozório, Sarno, Euzenir Nunes, Schmitz, Veronica

“…Erythema Nodosum Leprosum (ENL) is a recurrent acute inflammatory complication of leprosy affecting up to 50% of all Borderline Lepromatous and Lepromatous…”
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Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors by Schmitz, Veronica, Svensjö, Erik, Serra, Rafaela Rangel, Teixeira, Mauro M., Scharfstein, Julio

“…Previous analysis of the endogenous innate signals that steer T cell‐dependent immunity in mice acutely infected by the protozoan Trypanosoma cruzi revealed…”
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The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum by Rosa, Thabatta Leal Silveira Andrezo, Mendes, Mayara Abud, Linhares, Natasha Ribeiro Cardoso, Rodrigues, Thais Fernanda, Dias, André Alves, Leal-Calvo, Thyago, Gandini, Mariana, Ferreira, Helen, Costa, Fabrício da Mota Ramalho, Sales, Anna Maria, Amadeu, Thaís Porto, Schmitz, Veronica, Pinheiro, Roberta Olmo, Rodrigues, Luciana Silva, Moraes, Milton Ozório, Pessolani, Maria Cristina Vidal

“…In leprosy patients, acute inflammatory episodes, known as erythema nodosum leprosum (ENL), are responsible for high morbidity and tissue damage that occur…”
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CD64 expression on polymorphonuclear cells as a potential marker for monitoring the human cytomegalovirus replication after kidney transplantation by Carvalho, Fabiana R., Rosário, Natalia F., Souza, Cintia F., Schmitz, Veronica, Pinto, Fabiana A., Velarde, Luis Guillermo C., Lugon, Jocemir Ronaldo, Almeida, Jorge R., Silva, Andrea Alice da

“…ABSTRACT Human cytomegalovirus (HCMV) infection is the main cause of morbidity in kidney transplant recipients. This study aims to investigate if CD64…”
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Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain by Lima, Ana Paula C.A., Almeida, Paulo C., Tersariol, Ivarne L.S., Schmitz, Veronica, Schmaier, Alvin H., Juliano, Luiz, Hirata, Isaura Y., Müller-Esterl, Werner, Chagas, Jair R., Scharfstein, Julio

“…Trypanosoma cruzi activates the kinin pathway through the activity of its major cysteine proteinase, cruzipain. Because kininogen molecules may be displayed on…”
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