Search Results - "Vepsalainen, J."

Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid by Laakso, M P, Jukarainen, N M, Vepsäläinen, J

“…ObjectiveTo test whether the information obtained from cerebrospinal fluid (CSF) and analysed with high-field proton (1H) MR spectroscopy (MRS) would help the…”
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A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates by Mönkkönen, Hannu, Auriola, Seppo, Lehenkari, Petri, Kellinsalmi, Maarit, Hassinen, Ilmo E, Vepsäläinen, Jouko, Mönkkönen, Jukka

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. On the basis of…”
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Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…The structure-function analysis of 36 methylenebisphosphonates (BPs) as inhibitors of the phosphorolytic activity of native and drug-resistant forms of HIV-1…”
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Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses by Rajamäki, Anni, Lehtovirta, Lari, Niemeläinen, Mika, Reito, Aleksi, Parkkinen, Jyrki, Peräniemi, Sirpa, Vepsäläinen, Jouko, Eskelinen, Antti

“…Metal particles detached from metal-on-metal hip prostheses (MoM-THA) have been shown to cause inflammation and destruction of tissues. To further explore…”
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Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine by Khomutov, M. A., Hyvönen, M. T., Salikhov, A. I., Chizhov, A. O., Ryzhov, I. M., Kochetkov, S. N., Vepsäläinen, J., Keinänen, T. A., Khomutov, A. R.

“…A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C ‑methylated spermine (Spm) analogue,…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
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Analysis of free, mono- and diacetylated polyamines from human urine by LC–MS/MS by Häkkinen, Merja R., Roine, Antti, Auriola, Seppo, Tuokko, Antti, Veskimäe, Erik, Keinänen, Tuomo A., Lehtimäki, Terho, Oksala, Niku, Vepsäläinen, Jouko

“…•LC–MS/MS method was developed and validated to analyze polyamines from urine samples.•The method omits the laborious derivatization steps in the sample…”
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The combined use of constrained total-line-shape 1H NMR and LC–MS/MS for quantitative analysis of bioactive components in yellow onion by Soininen, Tuula H., Jukarainen, Niko, Julkunen-Tiitto, Riitta, Karjalainen, Reijo, Vepsäläinen, Jouko J.

“…► In this study we applied the CTLS application to onions. ► A total of 17 compounds were assigned and quantified from 1H NMR spectrum. ► The CTLS minimize…”
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Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence by Castro-Oropeza, R, Pino-Ángeles, A, Khomutov, M. A, Urdiales, J. L, Moya-García, A. A, Vepsäläinen, J, Persson , L, Sarabia , F, Khomutov, A, Sánchez-Jiménez, F

“…Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of…”
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Bisphosphonate prodrugs by Vepsäläinen, Jouko J

“…Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH…”
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Isolation and characterization of yuremamine, a new phytoindole by Vepsäläinen, Jouko J, Auriola, Seppo, Tukiainen, Mikko, Ropponen, Nina, Callaway, J C

“…Yuremamine was isolated and characterized from the stem bark of Mimosa tenuiflora. This plant is still used by indigenous peoples in North-eastern Brazil to…”
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Advanced material and approach for metal ions removal from aqueous solutions by Turhanen, Petri A., Vepsäläinen, Jouko J., Peräniemi, Sirpa

“…A Novel approach to remove metals from aqueous solutions has been developed. The method is based on a resin free, solid, non-toxic, microcrystalline…”
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Real-Time On-Site Multielement Analysis of Environmental Waters with a Portable X‑ray Fluorescence (pXRF) System by Tiihonen, Tommi E., Nissinen, Tuomo J., Turhanen, Petri A., Vepsäläinen, Jouko J., Riikonen, Joakim, Lehto, Vesa-Pekka

“…Strict regulations are in place to control the effluents of mining sites and other industries. Heavy metal contamination of aquatic systems caused by leakages…”
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Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase by Khomutov, M. A., Simonian, A. R., Weisell, J., Vepsalainen, J., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane),…”
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Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids by Khomutov, M. A., Formanovsky, A. A., Mikhura, I. V., Vepsalainen, J., Kochetkov, S. N., De Biase, D., Khomutov, A. R.

“…Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of…”
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Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis by Merentie, M, Uimari, A, Pietilä, M, Sinervirta, R, Keinänen, T. A, Vepsäläinen, J, Khomutov, A, Grigorenko, N, Herzig, K.-H, Jänne, J, Alhonen, L

“…The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition,…”
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Detection of water quality using simulated satellite data and semi-empirical algorithms in Finland by Härmä, Pekka, Vepsäläinen, Jenni, Hannonen, Tuula, Pyhälahti, Timo, Kämäri, Juha, Kallio, Kari, Eloheimo, Karri, Koponen, Sampsa

“…The aim of the study was to test the feasibility of the band combination of the TERRA MODIS and ENVISAT MERIS instruments for operational monitoring of lakes…”
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Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach by Turhanen, Petri A, Leppänen, Jukka, Vepsäläinen, Jouko J

“…The usefulness of dried Dowex H+ cation-exchange resin with or without sodium iodide (NaI) as a catalyst system for different kinds of esterifications using…”
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X-ray diffraction study of polymeric Mg complexes of clodronic acid by Kontturi, Mervi, Kunnas-Hiltunen, Susan, Vepsäläinen, Jouko J., Ahlgrén, Markku

“…Two Mg complexes of (dichloromethylene)bisphosphonic acid disodium salt, [{Mg(H 2O) 6}{Mg(Cl 2CP 2O 6)(H 2O)}⋅7H 2O] n ( 1) and [NaMg(Cl 2CP 2O 6H)(H 2O) 5] n…”
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