Search Results - "Venugopala, Katharigatta N."
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1
Omicron variant genome evolution and phylogenetics
Published in Journal of medical virology (01-04-2022)“…Following the discovery of the SARS‐CoV‐2 Omicron variant (B.1.1.529), the global COVID‐19 outbreak has resurfaced after appearing to be relentlessly spreading…”
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2
A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications
Published in Critical reviews in food science and nutrition (27-06-2019)“…Considered as the "King of spices", black pepper (Piper nigrum L.) is a widely used spice which adds flavor of its own to dishes, and also enhances the taste…”
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3
Targeting the DNA Damage Response Machinery for Lung Cancer Treatment
Published in Pharmaceuticals (Basel, Switzerland) (27-11-2022)“…Lung cancer is considered the most commonly diagnosed cancer and one of the leading causes of death globally. Despite the responses from small-cell lung cancer…”
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4
Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects
Published in Pharmaceuticals (Basel, Switzerland) (24-09-2024)“…Pyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of…”
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Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents
Published in Molecules (Basel, Switzerland) (21-06-2022)“…For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. The thiazole ring consists of sulfur and nitrogen in such a…”
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Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease
Published in Journal of biomolecular structure & dynamics (22-09-2021)“…SARS-CoV-2 or Coronavirus disease 19 (COVID-19) is a rapidly spreading, highly contagious, and sometimes fatal disease for which drug discovery and vaccine…”
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7
Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections
Published in PloS one (19-03-2021)“…In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was to…”
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ADMET Profiling in Drug Discovery and Development: Perspectives of In Silico, In Vitro and Integrated Approaches
Published in Current drug metabolism (01-01-2021)“…In the drug discovery setting, undesirable ADMET properties of a pharmacophore with good predictive power obtained after a tedious drug discovery and…”
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Icacinaceae Plant Family: A Recapitulation of the Ethnobotanical, Phytochemical, Pharmacological, and Biotechnological Aspects
Published in Current pharmaceutical design (01-01-2023)“…Icacinaceae, an Angiospermic family comprising 35 genera and 212 accepted species, including trees, shrubs, and lianas with pantropical distribution, is one of…”
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10
Reinforced electrospun nanofiber composites for drug delivery applications
Published in Journal of biomedical materials research. Part A (01-10-2021)“…Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery…”
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11
Three-Dimensional In Vitro Cell Culture Models for Efficient Drug Discovery: Progress So Far and Future Prospects
Published in Pharmaceuticals (Basel, Switzerland) (27-07-2022)“…Despite tremendous advancements in technologies and resources, drug discovery still remains a tedious and expensive process. Though most cells are cultured…”
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12
Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing
Published in Pharmaceutics (20-09-2020)“…The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in…”
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13
The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts - Current Status and Future Perspectives
Published in Mini reviews in medicinal chemistry (01-01-2021)“…Phytocompounds isolated from plants are well appraised for their broad pharmacological propensities in several pathologies. One key benefit of…”
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14
Computational Design, Synthesis, and Pharmacological Evaluation of Naproxen-Guaiacol Chimera for Gastro-Sparing Anti-Inflammatory Response by Selective COX2 Inhibition
Published in Molecules (Basel, Switzerland) (01-10-2022)“…The 4-allyl guaiacol is a natural phenolic molecule that has been widely studied for its antioxidant capacity against reactive-oxygen-species-mediated cellular…”
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In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2021)“…The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community…”
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Design, Synthesis, and In Vitro Evaluation of Novel Indolyl DiHydropyrazole Derivatives as Potential Anticancer Agents
Published in Molecules (Basel, Switzerland) (29-08-2021)“…Indoles derived from both natural sources or artificial synthetic methods have been known to interact with aryl hydrocarbon receptors (AhR), and exhibit…”
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Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection
Published in PloS one (16-10-2019)“…Neisseria meningitidis is the primary cause of bacterial meningitis in many parts of the world, with considerable mortality rates among neonates and adults. In…”
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18
Synthetic Mono/di-halogenated Coumarin Derivatives and Their Anticancer Properties
Published in Anti-cancer agents in medicinal chemistry (01-02-2017)“…Coumarins are naturally occurring plant metabolites and several synthetic coumarin analogues are known for their various pharmacological properties such as…”
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Current Scenario and Future Prospect in the Management of COVID-19
Published in Current medicinal chemistry (01-01-2021)“…The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of risk assessment, rapid spreading ability, and propensity to precipitate severe…”
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20
Development of Ecofriendly Derivative Spectrophotometric Methods for the Simultaneous Quantitative Analysis of Remogliflozin and Vildagliptin from Formulation
Published in Molecules (Basel, Switzerland) (12-10-2021)“…Three rapid, accurate, and ecofriendly processed spectrophotometric methods were validated for the concurrent quantification of remogliflozin (RGE) and…”
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