Search Results - "Ventura, John D."

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5 by Hachmann, Nicole P., Miller, Jessica, Collier, Ai-ris Y., Ventura, John D., Yu, Jingyou, Rowe, Marjorie, Bondzie, Esther A., Powers, Olivia, Surve, Nehalee, Hall, Kevin, Barouch, Dan H.

“…In a small study involving 54 participants, omicron subvariants BA.2.12.1, BA.4, and BA.5 of SARS-CoV-2 were more likely to escape neutralizing antibodies…”
Get full text

Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants by Yu, Jingyou, Collier, Ai-ris Y, Rowe, Marjorie, Mardas, Fatima, Ventura, John D, Wan, Huahua, Miller, Jessica, Powers, Olivia, Chung, Benjamin, Siamatu, Mazuba, Hachmann, Nicole P, Surve, Nehalee, Nampanya, Felix, Chandrashekar, Abishek, Barouch, Dan H

“…Although two doses of BNT162b2 vaccine produce immunity that wanes over time, the administration of a booster dose substantially increases the level of…”
Get full text

DNA vaccine protection against SARS-CoV-2 in rhesus macaques by Yu, Jingyou, Tostanoski, Lisa H, Peter, Lauren, Mercado, Noe B, McMahan, Katherine, Mahrokhian, Shant H, Nkolola, Joseph P, Liu, Jinyan, Li, Zhenfeng, Chandrashekar, Abishek, Martinez, David R, Loos, Carolin, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S, Slein, Matthew D, Chen, Yuezhou, Zuiani, Adam, Lelis, Felipe J N, Travers, Meghan, Habibi, Shaghayegh, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Brown, Renita, Cook, Anthony, Finneyfrock, Brad, Dodson, Alan, Teow, Elyse, Velasco, Jason, Zahn, Roland, Wegmann, Frank, Bondzie, Esther A, Dagotto, Gabriel, Gebre, Makda S, He, Xuan, Jacob-Dolan, Catherine, Kirilova, Marinela, Kordana, Nicole, Lin, Zijin, Maxfield, Lori F, Nampanya, Felix, Nityanandam, Ramya, Ventura, John D, Wan, Huahua, Cai, Yongfei, Chen, Bing, Schmidt, Aaron G, Wesemann, Duane R, Baric, Ralph S, Alter, Galit, Andersen, Hanne, Lewis, Mark G, Barouch, Dan H

“…The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a…”
Get full text

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins by Herschhorn, Alon, Ma, Xiaochu, Gu, Christopher, Ventura, John D, Castillo-Menendez, Luis, Melillo, Bruno, Terry, Daniel S, Smith, 3rd, Amos B, Blanchard, Scott C, Munro, James B, Mothes, Walther, Finzi, Andrés, Sodroski, Joseph

“…Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp41) ] typically exist in a metastable closed conformation (state 1)…”
Get full text

Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice by Ventura, John D, Beloor, Jagadish, Allen, Edward, Zhang, Tongyu, Haugh, Kelsey A, Uchil, Pradeep D, Ochsenbauer, Christina, Kieffer, Collin, Kumar, Priti, Hope, Thomas J, Mothes, Walther

“…Non-invasive bioluminescent imaging (NIBLI) of HIV-1 infection dynamics allows for real-time monitoring of viral spread and the localization of infected cell…”
Get full text

Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques by Cadena, Anthony M., Ventura, John D., Abbink, Peter, Borducchi, Erica N., Tuyishime, Hubert, Mercado, Noe B., Walker-Sperling, Victoria, Siamatu, Mazuba, Liu, Po-Ting, Chandrashekar, Abishek, Nkolola, Joseph P., McMahan, Katherine, Kordana, Nicole, Hamza, Venous, Bondzie, Esther A., Fray, Emily, Kumar, Mithra, Fischinger, Stephanie, Shin, Sally A., Lewis, Mark G., Siliciano, Robert F., Alter, Galit, Barouch, Dan H.

“…The establishment of a long-lived viral reservoir is the key obstacle for achieving an HIV-1 cure. However, the anatomic, virologic, and immunologic features…”
Get full text

Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice by Larocca, Rafael A, Abbink, Peter, Ventura, John D, Chandrashekar, Abishek, Mercado, Noe, Li, Zhenfeng, Borducchi, Erica, De La Barrera, Rafael A, Eckels, Kenneth H, Modjarrad, Kayvon, Busch, Michael P, Michael, Nelson L, Barouch, Dan H

“…Pre-existing immunity to flaviviruses can influence the outcome of subsequent flavivirus infections. Therefore, it is critical to determine whether baseline…”
Get full text

Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex by Dagotto, Gabriel, Ventura, John D., Martinez, David R., Anioke, Tochi, Chung, Benjamin S., Siamatu, Mazuba, Barrett, Julia, Miller, Jessica, Schäfer, Alexandra, Yu, Jingyou, Tostanoski, Lisa H., Wagh, Kshitij, Baric, Ralph S., Korber, Bette, Barouch, Dan H.

“…The COVID-19 pandemic marks the third coronavirus pandemic this century (SARS-CoV-1, MERS, SARS-CoV-2), emphasizing the need to identify and evaluate conserved…”
Get full text

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques by Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Rosendahl Huber, Sietske K., Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, Barouch, Dan H.

“…A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19)…”
Get full text

Human Immunodeficiency Virus 1 (HIV-1): Viral Latency, the Reservoir, and the Cure by Ventura, John D

“…An estimated 37 million people globally suffer from Human Immunodeficiency Virus-1 (HIV-1) infection with 1.7 million newly acquired infections occurring on…”
Get full text

Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques by Ventura, John D., Nkolola, Joseph P., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Mercado, Noe B., Hope, David L., Giffin, Victoria M., McMahan, Katherine, Geleziunas, Romas, Murry, Jeffrey P., Yang, Yunling, Lewis, Mark G., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Robb, Merlin L., Michael, Nelson L., Barouch, Dan H.

“…Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure…”
Get full text

Rapid Loss of CD4 T Cells by Pyroptosis during Acute SIV Infection in Rhesus Macaques by He, Xuan, Aid, Malika, Ventura, John D, Borducchi, Erica, Lifton, Michelle, Liu, Jinyan, Barouch, Dan H

“…The mechanisms underlying depletion of CD4 T cells during acute HIV-1 infection are not well understood. Here we show that caspase-1-induced pyroptosis, a…”
Get full text

Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera by Vidal, Samuel J, Collier, Ai-Ris Y, Yu, Jingyou, McMahan, Katherine, Tostanoski, Lisa H, Ventura, John D, Aid, Malika, Peter, Lauren, Jacob-Dolan, Catherine, Anioke, Tochi, Chang, Aiquan, Wan, Huahua, Aguayo, Ricardo, Ngo, Debby, Gerszten, Robert E, Seaman, Michael S, Barouch, Dan H

“…Emerging SARS-CoV-2 variants of concern that overcome natural and vaccine-induced immunity threaten to exacerbate the COVID-19 pandemic. Increasing evidence…”
Get full text

Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2 by Tostanoski, Lisa H, Gralinski, Lisa E, Martinez, David R, Schaefer, Alexandra, Mahrokhian, Shant H, Li, Zhenfeng, Nampanya, Felix, Wan, Huahua, Yu, Jingyou, Chang, Aiquan, Liu, Jinyan, McMahan, Katherine, Ventura, John D, Dinnon, Kenneth H, Leist, Sarah R, Baric, Ralph S, Barouch, Dan H

“…The global COVID-19 pandemic has sparked intense interest in the rapid development of vaccines as well as animal models to evaluate vaccine candidates and to…”
Get full text

Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants by Fray, Emily J., Wu, Fengting, Simonetti, Francesco R., Zitzmann, Carolin, Sambaturu, Narmada, Molina-Paris, Carmen, Bender, Alexandra M., Liu, Po-Ting, Ventura, John D., Wiseman, Roger W., O’Connor, David H., Geleziunas, Romas, Leitner, Thomas, Ribeiro, Ruy M., Perelson, Alan S., Barouch, Dan H., Siliciano, Janet D., Siliciano, Robert F.

“…The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We evaluated the frequency of simian immunodeficiency virus…”
Get full text

A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus by Uchil, Pradeep D., Pi, Ruoxi, Haugh, Kelsey A., Ladinsky, Mark S., Ventura, John D., Barrett, Brad S., Santiago, Mario L., Bjorkman, Pamela J., Kassiotis, George, Sewald, Xaver, Mothes, Walther

“…Lymph- and blood-borne retroviruses exploit CD169/Siglec-1-mediated capture by subcapsular sinus and marginal zone metallophilic macrophages for…”
Get full text

Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques by Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Huber, Sietske K. Rosendahl, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, Barouch, Dan H.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03100-y…”
Get full text

Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K, Nadeef, Seba, Daristotle, John L, Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A, Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H, Hachmann, Nicole, Wang, Erika Yan, Ventura, John D, Barouch, Dan H, Langer, Robert, Jaklenec, Ana

“…Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale…”
Get full text

Longitudinal Imaging of HIV-1 Infection and Recrudescence in Humanized Mice by Ventura, John D

“…An estimated 37 million people globally suffer from Human Immunodeficiency Virus-1 (HIV-1) infection with 1.7 million newly acquired infections occurring on…”
Get full text

Replication of a Multidisciplinary Hospital Based Clinical Pathway for the Management of Low Back Pain by Allgeier, Michael, DC, MDT, Ventura, John M., DC, Murphy, Donald R., DC

Get full text