Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-CD36-binding PfEMP1s are associated with prot...

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Bibliographic Details
Published in:Scientific reports Vol. 11; no. 1; pp. 14401 - 14
Main Authors: Ventimiglia, Noah T., Stucke, Emily M., Coulibaly, Drissa, Berry, Andrea A., Lyke, Kirsten E., Laurens, Matthew B., Bailey, Jason A., Adams, Matthew, Niangaly, Amadou, Kone, Abdoulaye K., Takala-Harrison, Shannon, Kouriba, Bourema, Doumbo, Ogobara K., Felgner, Phillip L., Plowe, Christopher V., Thera, Mahamadou A., Travassos, Mark A.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 13-07-2021
Nature Publishing Group
Nature Portfolio
Subjects:
631/250/255/1629
631/326/417/2546
692/699/255/1629
Adhesion
Adult
Asymptomatic infection
CD36 antigen
Cell adhesion
Disease transmission
Dry season
Endothelium
Erythrocyte Membrane - metabolism
Erythrocytes
Humanities and Social Sciences
Humans
Intercellular adhesion molecule 1
Malaria
Membrane proteins
multidisciplinary
Plasmodium falciparum
Protein arrays
Protein C
Proteins
Protozoan Proteins - metabolism
Science
Science (multidisciplinary)
Seasonal variations
Seasons
Vector-borne diseases
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Summary:Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-CD36-binding PfEMP1s are associated with protection against severe disease. We hypothesized that given lifelong P. falciparum exposure, Malian adults would have broad PfEMP1 serorecognition and high seroreactivity levels during follow-up, particularly to non-CD36-binding PfEMP1s such as those that attach to endothelial protein C receptor (EPCR) and intercellular adhesion molecule-1 (ICAM-1). Using a protein microarray, we determined serologic responses to 166 reference PfEMP1 fragments during a dry and subsequent malaria transmission season in Malian adults. Malian adult sera had PfEMP1 serologic responses throughout the year, with decreased reactivity to a small subset of PfEMP1 fragments during the dry season and increases in reactivity to a different subset of PfEMP1 fragments during the subsequent peak malaria transmission season, especially for intracellular PfEMP1 domains. For some individuals, PfEMP1 serologic responses increased after the dry season, suggesting antigenic switching during asymptomatic infection. Adults were more likely to experience variable serorecognition of CD36-binding PfEMP1s than non-CD36-binding PfEMP1s that bind EPCR or ICAM-1, which remained serorecognized throughout the year. Sustained seroreactivity to non-CD36-binding PfEMP1s throughout adulthood amid seasonal fluctuation patterns may reflect underlying protective severe malaria immunity and merits further investigation.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92974-7