Search Results - "Ventham, T"

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics by Ventham, Nicholas T, Kennedy, Nicholas A, Nimmo, Elaine R, Satsangi, Jack

“…In the past decade, there have been fundamental advances in our understanding of genetic factors that contribute to the inflammatory bowel diseases (IBDs)…”
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Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD by Boyapati, Ray K, Dorward, David A, Tamborska, Arina, Kalla, Rahul, Ventham, Nicholas T, Doherty, Mary K, Whitfield, Philip D, Gray, Mohini, Loane, Joseph, Rossi, Adriano G, Satsangi, Jack, Ho, Gwo-tzer

“…Abstract Background Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many similarities with immunogenic bacterial DNA. MtDNA is recognized…”
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Serum Calprotectin: A Novel Diagnostic and Prognostic Marker in Inflammatory Bowel Diseases by Kalla, Rahul, Kennedy, Nicholas A, Ventham, Nicholas T, Boyapati, Ray K, Adams, Alex T, Nimmo, Elaine R, Visconti, Micaela R, Drummond, Hazel, Ho, Gwo-Tzer, Pattenden, Rebecca J, Wilson, David C, Satsangi, Jack

“…There is an unmet need for novel blood-based biomarkers that offer timely and accurate diagnostic and prognostic testing in inflammatory bowel diseases (IBD)…”
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Systematic review and meta-analysis of continuous local anaesthetic wound infiltration versus epidural analgesia for postoperative pain following abdominal surgery by Ventham, N. T., Hughes, M., O'Neill, S., Johns, N., Brady, R. R., Wigmore, S. J.

“…Background Local anaesthetic wound infiltration techniques reduce opiate requirements and pain scores. Wound catheters have been introduced to increase the…”
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Clinical effectiveness of transversus abdominis plane (TAP) block in abdominal surgery: a systematic review and meta-analysis by Johns, N., O'Neill, S., Ventham, N. T., Barron, F., Brady, R. R., Daniel, T.

“…Aim  Reduced opioid use in the immediate postoperative period is associated with decreased complications. This study aimed to determine the effect of…”
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Crohn’s disease by Kalla, Rahul, Ventham, Nicholas T, Satsangi, Jack, Arnott, Ian D R

“…Crohn's disease is a chronic inflammatory disorder that can affect any part of the gastrointestinal tract. Although the disease most commonly presents at a…”
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Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease by Zhang, Han, Kalla, Rahul, Chen, Jie, Zhao, Jianhui, Zhou, Xuan, Adams, Alex, Noble, Alexandra, Ventham, Nicholas T., Wellens, Judith, Ho, Gwo-Tzer, Dunlop, Malcolm G., Nowak, Jan Krzysztof, Ding, Yuan, Liu, Zhanju, Satsangi, Jack, Theodoratou, Evropi, Li, Xue

“…This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian…”
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Analgesia after open abdominal surgery in the setting of enhanced recovery surgery: a systematic review and meta-analysis by Hughes, Michael J, Ventham, Nicholas T, McNally, Stephen, Harrison, Ewen, Wigmore, Stephen

“…The optimal analgesic technique following open abdominal surgery within an enhanced recovery protocol remains controversial. Thoracic epidural is often…”
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Acute colonic obstruction within a congenital Bochdalek diaphragmatic hernia following colonoscopy by Ventham, Nicholas T., Zanellato, Artur, McKechnie, Peter Stuart

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Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease by Kalla, R, Adams, A T, Bergemalm, D, Vatn, S, Kennedy, N A, Ricanek, P, Lindstrom, J, Ocklind, A, Hjelm, F, Ventham, N T, Ho, G T, Petren, C, Repsilber, D, Söderholm, J, Pierik, M, D’Amato, M, Gomollón, F, Olbjorn, C, Jahnsen, J, Vatn, M H, Halfvarson, J, Satsangi, J

“…Abstract Background Success in personalized medicine in complex disease is critically dependent on biomarker discovery. We profiled serum proteins using a…”
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Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease by Ventham, N. T., Kennedy, N. A., Adams, A. T., Kalla, R., Heath, S., O'Leary, K. R., Drummond, H., Wilson, D. C., Gut, I. G., Nimmo, E. R., Satsangi, J.

“…Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA…”
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Meta-analysis of the effect of perioperative intravenous lidocaine on return of gastrointestinal function after colorectal surgery by Cooke, C., Kennedy, E. D., Foo, I., Nimmo, S., Speake, D., Paterson, H. M., Ventham, N. T.

“…Background Return of normal gastrointestinal (GI) function is a critical determinant of recovery after colorectal surgery. The aim of this meta-analysis was to…”
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Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease by Klasić, Marija, Markulin, Dora, Vojta, Aleksandar, Samaržija, Ivana, Biruš, Ivan, Dobrinić, Paula, Ventham, Nicholas T, Trbojević-Akmačić, Irena, Šimurina, Mirna, Štambuk, Jerko, Razdorov, Genadij, Kennedy, Nicholas A, Satsangi, Jack, Dias, Ana M, Pinho, Salome, Annese, Vito, Latiano, Anna, D'Inca, Renata, Lauc, Gordan, Zoldoš, Vlatka

“…Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD)…”
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Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease by Kalla, R, Adams, A T, Ventham, N T, Kennedy, N A, White, R, Clarke, C, Ivens, A, Bergemalm, D, Vatn, S, Lopez-Jimena, B, Ricanek, P, Vatn, M H, Söderholm, Johan D, Gomollón, F, Nowak, J K, Jahnsen, J, Halfvarson, J, McTaggart, S, Ho, G T, Buck, A, Satsangi, J

“…Abstract Background MicroRNAs [miRNAs] are cell-specific small non-coding RNAs that can regulate gene expression and have been implicated in inflammatory bowel…”
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Comparison of mortality following hospitalisation for ulcerative colitis in Scotland between 1998–2000 and 2007–2009 by Ventham, N. T., Kennedy, N. A., Duffy, A., Clark, D. N., Crowe, A. M., Knight, A. D., Nicholls, R. J., Satsangi, J.

“…Summary Background Scottish nationwide linkage data from 1998 to 2000 demonstrated high 3‐year mortality in patients hospitalised with ulcerative colitis (UC)…”
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Correction: changes to serum sample tube and processing methodology does not cause inter-individual variation in automated whole serum N-glycan profiling in health and disease by Ventham, Nicholas T, Gardner, Richard A, Kennedy, Nicholas A, Shubhakar, Archana, Kalla, Rahul, Nimmo, Elaine R, Fernandes, Daryl L, Satsangi, Jack, Spencer, Daniel I R

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MicroRNAs: new players in IBD by Kalla, R, Ventham, N T, Kennedy, N A, Quintana, J F, Nimmo, E R, Buck, A H, Satsangi, J

“…MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly…”
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An Unusual Cause of Rectal Pain by Leow, Hui Wei, Coupland, Alexander, Ventham, Nicholas T.

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Open transversus abdominis plane block and analgesic requirements in patients following right hemicolectomy by Brady, R R, Ventham, N T, Roberts, D M, Graham, C, Daniel, T

“…Reducing exogenously administered opioids in the post-operative period is associated with early return of bowel function and decreased post-operative…”
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Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis by Gasparetto, Marco, Payne, Felicity, Nayak, Komal, Kraiczy, Judith, Glemas, Claire, Philip-McKenzie, Yosef, Ross, Alexander, Edgar, Rachel D., Zerbino, Daniel R., Salvestrini, Camilla, Torrente, Franco, Ventham, Nicholas T., Kalla, Rahul, Satsangi, Jack, Sarkies, Peter, Heuschkel, Robert, Zilbauer, Matthias

“…Gene expression patterns of CD8+ T cells have been reported to correlate with clinical outcomes of adults with inflammatory bowel diseases (IBD). We aimed to…”
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