Search Results - "Venot, André"

Extension and validation of the GLYCAM force field parameters for modeling glycosaminoglycans by Singh, Arunima, Tessier, Matthew B, Pederson, Kari, Wang, Xiaocong, Venot, Andre P, Boons, Geert-Jan, Prestegard, James H, Woods, Robert J

“…Glycosaminoglycans (GAGs) are an important class of carbohydrates that serve critical roles in blood clotting, tissue repair, cell migration and adhesion, and…”
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Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies by Arungundram, Sailaja, Al-Mafraji, Kanar, Asong, Jinkeng, Leach, Franklin E, Amster, I. Jonathan, Venot, Andre, Turnbull, Jeremy E, Boons, Geert-Jan

“…Although hundreds of heparan sulfate binding proteins have been identified and implicated in a myriad of physiological and pathological processes, very little…”
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High-Field Asymmetric-Waveform Ion Mobility Spectrometry and Electron Detachment Dissociation of Isobaric Mixtures of Glycosaminoglycans by Kailemia, Muchena J., Park, Melvin, Kaplan, Desmond A., Venot, Andre, Boons, Geert-Jan, Li, Lingyun, Linhardt, Robert J., Amster, I. Jonathan

“…High-field asymmetric waveform ion mobility spectrometry (FAIMS) is shown to be capable of resolving isomeric and isobaric glycosaminoglycan negative ions and…”
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One-Pot Synthesis of Oligosaccharides by Combining Reductive Openings of Benzylidene Acetals and Glycosylations by Vohra, Yusuf, Vasan, Mahalakshmi, Venot, Andre, Boons, Geert-Jan

“…Combining triflic acid-promoted glycosylations of trichloroacetimidates with reductive opening of benzylidene acetals with triflic acid and triethylsilane as…”
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Multivariate Analysis of Electron Detachment Dissociation and Infrared Multiphoton Dissociation Mass Spectra of Heparan Sulfate Tetrasaccharides Differing Only in Hexuronic acid Stereochemistry by Oh, Han Bin, Leach, Franklin E., Arungundram, Sailaja, Al-Mafraji, Kanar, Venot, Andre, Boons, Geert-Jan, Amster, I. Jonathan

“…The structural characterization of glycosaminoglycan (GAG) carbohydrates by mass spectrometry has been a long-standing analytical challenge due to the inherent…”
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NMR Structural Characterization of Substrates Bound to N-Acetylglucosaminyltransferase V by Macnaughtan, Megan A., Kamar, Maria, Alvarez-Manilla, Gerardo, Venot, Andre, Glushka, John, Pierce, J. Michael, Prestegard, James H.

“…N-Acetylglucosaminyltransferase V (GnT-V) is an enzyme involved in the biosynthesis of asparagine-linked oligosaccharides. It is responsible for the transfer…”
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Five specificity patterns of (1----3)-alpha-L-fucosyltransferase activity defined by use of synthetic oligosaccharide acceptors. Differential expression of the enzymes during human embryonic development and in adult tissues by Mollicone, R, Candelier, J J, Mennesson, B, Couillin, P, Venot, A P, Oriol, R

“…The use of synthetic trisaccharides as acceptors led to the definition of five main (1---3)-alpha-L-fucosyltransferase activity patterns in human adult…”
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Distance mapping of protein‐binding sites using spin‐labeled oligosaccharide ligands by Jain, Nitin U., Venot, Andre, Umemoto, Kimiko, Leffler, Hakon, Prestegard, James H.

“…The binding of a nitroxide spin‐labeled analog of N‐acetyllactosamine to galectin‐3, a mammalian lectin of 26 kD size, is studied to map the binding sites of…”
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α-(2,6)-Sialyltransferase-Catalyzed Sialylations of Conformationally Constrained Oligosaccharides by Galan, M. Carmen, Venot, Andre P, Glushka, John, Imberty, Anne, Boons, Geert-Jan

“…It is demonstrated that conformationally restricted oligosaccharides can act as acceptors for glycosyltransferases. Correlation of the conformational…”
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Disaccharide Mimetics of the Aminoglycoside Antibiotic Neamine by Venot, Andre, Swayze, Eric E, Griffey, Richard H, Boons, Geert-Jan

“…A highly convergent approach has been employed for the facile synthesis of a library of 24 disaccharides that are α(1-3), β(1-3), α(1-4), or β(1-4) linked and…”
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Chemical Synthesis of Δ‑4,5 Unsaturated Heparan Sulfate Oligosaccharides for Biomarker Discovery by Joshi, Apoorva, Chopra, Pradeep, Venot, Andre, Boons, Geert-Jan

“…A methodology is described that can provide heparan sulfate oligosaccharides having a Δ4,5-double bond, which are needed as analytical standards and biomarkers…”
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Identification of a Developmental Chemoattractant in Myxococcus xanthus through Metabolic Engineering by Kearns, Daniel B., Venot, Andre, Bonner, Pamela J., Stevens, Brian, Boons, Geert-Jan, Shimkets, Lawrence J.

“…Fruiting body formation of Myxococcus xanthus requires the ordered migration of tens of thousands of cells by using a form of surface motility known as gliding…”
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Trisaccharide mimetics of the aminoglycoside antibiotic neomycin by Rao, Yu, Venot, Andre, Swayze, Eric E, Griffey, Richard H, Boons, Geert-Jan

“…A highly convergent approach for the chemical synthesis of eight structurally related trisaccharides that contain 3 to 5 amino groups has been described…”
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Enzymic synthesis of oligosaccharides terminating in the tumor-associated sialyl-Lewis-a determinant by Palcic, M M, Venot, A P, Ratcliffe, R M, Hindsgaul, O

“…The isomeric sialyl-Lea-terminating pentasaccharide derivatives, alpha-Neup5Ac-(2---3)-beta-D-Galp-(1---3)-[alpha-L-Fucp-(1 ---4)]-beta-…”
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Glycosyltransferase Activity Can Be Modulated by Small Conformational Changes of Acceptor Substrates by Galan, M. Carmen, Venot, Andre P, Boons, Geert-Jan

“…A range of N-acetyllactosamine derivatives (compounds 4−7) that have restricted mobilities around their glycosidic linkages have been employed to determine how…”
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Chemo-enzymatic synthesis of conformationally constrained oligosaccharides by Galan, M Carmen, Venot, Andre P, Glushka, John, Imberty, Anne, Boons, Geert-Jan

“…N-Acetyllactosamine derivative 4, which has a methylene amide tether between C-6 and C-2', was enzymatically glycosylated using rat liver…”
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Heparan Sulfate Microarray Reveals That Heparan Sulfate–Protein Binding Exhibits Different Ligand Requirements by Zong, Chengli, Venot, Andre, Li, Xiuru, Lu, Weigang, Xiao, Wenyuan, Wilkes, Jo-Setti L, Salanga, Catherina L, Handel, Tracy M, Wang, Lianchun, Wolfert, Margreet A, Boons, Geert-Jan

“…Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of physiological and disease-processes. Variations in HS epimerization and…”
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Carbohydrate-Protein Interactions in Vascular Biology by Nelson, R M, Venot, A, Bevilacqua, M P, Linhardt, R J, Stamenkovic, I

“…Carbohydrate-protein interactions participate in a wide variety of biological and pathological events. In recent years, particular attention has been paid to…”
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Fluorous Supported Modular Synthesis of Heparan Sulfate Oligosaccharides by Zong, Chengli, Venot, Andre, Dhamale, Omkar, Boons, Geert-Jan

“…The modular synthesis of heparan sulfate fragments is greatly facilitated by employing an anomeric aminopentyl linker protected by a benzyloxycarbonyl group…”
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Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substrates by GALAN, M. Carmen, DODSON, Christopher S, VENOT, Andre P, BOONS, Geert-Jan

“…A range of N-acetyllactosamine derivatives, which are modified by a wide range of functionalities at C-2(') and C-6, have been synthesised and the kinetic…”
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