Search Results - "Venneti, S."

Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1H-MR Spectroscopy by Tamrazi, B, Venneti, S, Margol, A, Hawes, D, Cen, S Y, Nelson, M, Judkins, A, Biegel, J, Blüml, S

“…BACKGROUND AND PURPOSEAtypical teratoid/rhabdoid tumors are rare, aggressive central nervous system tumors that are predominantly encountered in very young…”
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Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1 H-MR Spectroscopy by Tamrazi, B, Venneti, S, Margol, A, Hawes, D, Cen, S Y, Nelson, M, Judkins, A, Biegel, J, Blüml, S

“…Atypical teratoid/rhabdoid tumors are rare, aggressive central nervous system tumors that are predominantly encountered in very young children. Our aim was to…”
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MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma by Mucaj, V, Lee, S S, Skuli, N, Giannoukos, D N, Qiu, B, Eisinger-Mathason, T S K, Nakazawa, M S, Shay, J E S, Gopal, P P, Venneti, S, Lal, P, Minn, A J, Simon, M C, Mathew, L K

“…Glioblastomas are aggressive adult brain tumors, characterized by inadequately organized vasculature and consequent nutrient and oxygen (O 2 )-depleted areas…”
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The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: Implications for PET imaging by Venneti, Sriram, Wagner, Amy K., Wang, Guoji, Slagel, Susan L., Chen, Xiangbai, Lopresti, Brian J., Mathis, Chester A., Wiley, Clayton A.

“…Traumatic brain injury (TBI) is a significant cause of mortality, morbidity, and disability. Microglial activation is commonly observed in response to neuronal…”
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NMDA and Glutamate Evoke Excitotoxicity at Distinct Cellular Locations in Rat Cortical Neurons In Vitro by Sinor, Jeroo D, Du, Shen, Venneti, Sriram, Blitzblau, Rachel C, Leszkiewicz, Daniel N, Rosenberg, Paul A, Aizenman, Elias

“…The development of cortical neurons in vivo and in vitro is accompanied by alterations in NMDA receptor subunit expression and concomitant modifications in the…”
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The high-affinity peripheral benzodiazepine receptor ligand [C-11]DAA1106 results in improved delineation of neuroinflammatory lesions in a rodent model of disease compared to [C-11]PK11195 by Lopresti, Brian, Venneti, S., Wang, G., Mason, N.S., Mathis, C.A., Slagel, S., Hastings, T., Smith, A., Suhara, T., Zigmond, M., Wiley, C.

“…[...]PK11195 showed a much lower affinity for PBDR compared to DAA1106 in both rat (Kd = 4.0 ± 0.7 vs. 0.4 ± 0.2 nM) and human (Kd = 28 ± 8 nM vs. 3.0 ± 0.7…”
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Identification of Excellent Prognosis IDH Wildtype Glioblastomas Using Genomic and Metabolic Profiling by Edwards, D.M., Hopkins, A., Scott, A., Mannan, R., Cao, X., Zhang, L., Andren, A., Heth, J.A., Muraszko, K., Sagher, O., Orringer, D., Hollon, T., Hervey-Jumper, S., Venneti, S., Camelo-Piragua, S., Al-Holou, W., Chinnaiyan, A., Lyssiotis, C.A., Wahl, D.R.

“…High grade gliomas (HGGs) are aggressive brain tumors with altered cellular metabolism. HGGs can carry mutations in the tricarboxylic acid (TCA) cycle enzyme…”
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Induction of sarcomas by mutant IDH2 by Lu, Chao, Venneti, Sriram, Akalin, Altuna, Fang, Fang, Ward, Patrick S, Dematteo, Raymond G, Intlekofer, Andrew M, Chen, Chong, Ye, Jiangbin, Hameed, Meera, Nafa, Khedoudja, Agaram, Narasimhan P, Cross, Justin R, Khanin, Raya, Mason, Christopher E, Healey, John H, Lowe, Scott W, Schwartz, Gary K, Melnick, Ari, Thompson, Craig B

“…More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we…”
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The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders by Venneti, Sriram, Wang, Guoji, Nguyen, Jason, Wiley, Clayton A

“…Chronic microglial activation is an important component of many neurological disorders, and imaging activated microglia in vivo will enable the detection and…”
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HG-07 DETECTION OF K27M MUTANT PEDIATRIC GLIOBLASTOMAS BY IMMUNOHISTOCHEMISTRY by Venneti, S., Santi, M., Felicella, M. M., Yarilin, D., Phillips, J., Sullivan, L., Martinez, D., Perry, A., Lewis, P., Thompson, C., Judkins, A.

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EG-08 IDH MUTATIONS IN GLIOMAS ASSOCIATED WITH ENCHONDROMATOSIS by Nicholas, M. K., Joseph, L., Venneti, S., Daher, A., Pytel, P.

“…The enchondromatoses, Ollier's disease and Maffucci syndrome, are non-heritable developmental disorders characterized by multiple enchondromas (Olllier's) in…”
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Longitudinal in Vivo Positron Emission Tomography Imaging of Infected and Activated Brain Macrophages in a Macaque Model of Human Immunodeficiency Virus Encephalitis Correlates with Central and Peripheral Markers of Encephalitis and Areas of Synaptic Degeneration by Venneti, Sriram, Bonneh-Barkay, Dafna, Lopresti, Brian J, Bissel, Stephanie J, Wang, Guoji, Mathis, Chester A, Piatak, Michael, Lifson, Jeffrey D, Nyaundi, Julia O, Murphey-Corb, Michael, Wiley, Clayton A

“…Human immunodeficiency virus encephalitis is characterized by infiltration of the brain with infected and activated macrophages; however, it is not known why…”
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TM-15 GLUTAMINE BASED PET IMAGING FACILITATES ENHANCED METABOLIC DETECTION OF GLIOMAS IN VIVO by Venneti, S., Dunphy, M., Zhang, H., Pitter, K., Campos, C., Carlin, S., Lyashchenko, S., Ploessl, C., Rohle, D., Omuro, A., Cross, J., Brennan, C., Weber, W., Holland, E., Mellinghoff, I., Kung, H., Lewis, J., Thompson, C.

“…Glutamine is the most abundant plasma amino acid and many cancers show altered glutamine metabolism. We evaluated glutamine uptake and metabolism in gliomas…”
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HISTOPATHOLOGIC EVALUATION OF H3K27ME3 IS A PROGNOSTIC BIOMARKER FOR PEDIATRIC GLIOBLASTOMAS by Judkins, A. R., Venneti, S., Santi, M., Felicella, M. M., Sullivan, L. M., Dolgalev, I., Martinez, D., Perry, A., Lewis, P. W., Allis, D. C., Thompson, C. B.

“…BACKGROUND: Up to 30% of pediatric glioblastomas (GB) demonstrate mutations in H3F3A, a gene variant encoding histone H3.3. Global reduction in H3K27me3 is…”
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Optic Nerve Biopsy in the Management of Progressive Optic Neuropathy by Levin, Marc H, Ney, Joshua J, Venneti, Sriram, Moster, Mark L, Balcer, Laura J, Volpe, Nicholas J, Gausas, Roberta E, Liu, Grant T, Vagefi, M Reza, Galetta, Steven L

“…BACKGROUND:In cases of progressive optic neuropathy, diagnostic uncertainty often persists despite extensive work-up. Optic nerve biopsy (ONB) can be…”
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PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS by Venneti, Sriram, Lopresti, Brian J, Wang, Guoji, Bissel, Stephanie J, Mathis, Chester A, Meltzer, Carolyn C, Boada, Fernando, Capuano, 3rd, Saverio, Kress, Geraldine J, Davis, Denise K, Ruszkiewicz, James, Reynolds, Ian J, Murphey-Corb, Michael, Trichel, Anita M, Wisniewski, Stephen R, Wiley, Clayton A

“…HIV infection in humans and simian immunodeficiency virus (SIV) infection in macaques result in encephalitis in approximately one-quarter of infected…”
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CELL BIOLOGY AND SIGNALING by Furnari, F., Fenton, T., Nathanson, D., de Alberquerque, C. P., Kuga, D., Wanami, A., Dang, J., Yang, H., Tanaka, K., Gao, L., Oba-Shinjo, S., Uno, M., Inda, M.-d.-M., Bachoo, R., James, C. D., DePinho, R., Vandenberg, S., Zhou, H., Marie, S., Mischel, P., Cavenee, W., Szerlip, N., Pedraza, A., Huse, J., Mikkelsen, T., Brennan, C., Castellani, R. J., Ivanova, S., Gerzanich, V. V., Simard, J. M., Ito, M., See, W., Mukherjee, J., Ohba, S., Tan, I.-L., Pieper, R. O., Lukiw, W. J., Culicchia, F., Pogue, A., Bhattacharjee, S., Zhao, Y., Proescholdt, M. A., Merrill, M., Storr, E. M., Lohmeier, A., Brawanski, A., Abraham, S., Jensen, R., Khatua, S., Gopal, U., Du, J., He, F., Golub, T., Isaacs, J. S., Dietrich, J., Kalogirou-Valtis, Y., Ly, I., Scadden, D., Proschel, C., Mayer-Proschel, M., Rempel, S. A., Schultz, C. R., Golembieski, W., Brodie, C., Mathew, L. K., Skuli, N., Mucaj, V., Imtiyaz, H. Z., Venneti, S., Lal, P., Zhang, Z., Davuluri, R. V., Koch, C., Evans, S., Simon, M. C., Ranganathan, P., Clark, P., Salamat, S., Kuo, J. S., Kalejta, R. F., Bhattacharjee, B., Renzette, N., Moser, R. P., Kowalik, T. F., McFarland, B. C., Ma, J.-Y., Langford, C. P., Gillespie, G. Y., Yu, H., Zheng, Y., Nozell, S. E., Huszar, D., Benveniste, E. N., Lawrence, J. E., Cook, N. J., Rovin, R. A., Winn, R. J., Godlewski, J. A., Ogawa, D., Bronisz, A.

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