Search Results - "Venn, R F"

Molecularly imprinted polymers for the determination of a pharmaceutical development compound in plasma using 96-well MISPE technology by Chassaing, C, Stokes, J, Venn, R.F, Lanza, F, Sellergren, B, Holmberg, A, Berggren, C

“…The use of molecularly imprinted polymers (MIPs) as sorbents for the solid phase extraction (SPE) of a pharmaceutical compound in development, prior to…”
Get full text

Synthesis and properties of molecular imprints of darifenacin: The potential of molecular imprinting for bioanalysis by Venn, R. F., Goody, R. J.

Get full text

Rapid, Solid Phase Extraction Technique for the High-Throughput Assay of Darifenacin in Human Plasma by Kaye, Barry, Herron, William J, Macrae, Paul V, Robinson, Sylvia, Stopher, David A, Venn, Richard F, Wild, William

“…A novel method has been developed for the rapid solid phase extraction of drugs and metabolites from biological fluids, prior to further analysis. The newly…”
Get full text

Potential role for P-glycoprotein in the nonproportional pharmacokinetics of UK-343,664 in man by Abel, S., Beaumont, K. C., Crespi, C. L., Eva, M. D., Fox, L., Hyland, R., Jones, B. C., Muirhead, G. J., Smith, D. A., Venn, R. F., Walker, D. K.

“…1. UK-343,664 is a potent and specific PDE5 inhibitor. Following single oral doses to human volunteers, it exhibited non-proportional pharmacokinetics over the…”
Get full text

Fluorescence determination of sulphobutylether-β-cyclodextrin in human plasma by size exclusion chromatography with inclusion complex formation by Gage, Richard, Venn, Richard F, Bayliss, Mark A.J, Edgington, Alan M, Roffey, Sarah J, Sorrell, Brian

“…A selective method for the determination of sulphobutylether-β-cyclodextrin (SBECD) in human plasma has been developed and validated over the range 4–200 μg ml…”
Get full text

A direct comparison of the performance of ground, beaded and silica-grafted MIPs in HPLC and Turbulent Flow Chromatography applications by Fairhurst, Robert E., Chassaing, Christophe, Venn, Richard F., Mayes, Andrew G.

“…Spherical molecularly imprinted polymers (MIPs) specific to the β-blocker propranolol have been synthesised using two different approaches and compared to…”
Get full text

Analysis of CP-122,288 at femto-molar levels from human plasma using solid-supported extraction and HPLC column switching by Saunders, K. C, Venn, R. F, Fane, J. A

“…A sensitive and specific method for the analysis of CP-122,288 in plasma has been developed and validated using column-switching HPLC with fluorescence…”
Get full text

Fluorescence determination of sulphobutylether-β-cyclodextrin sodium in human plasma and urine by size-exclusion chromatography with inclusion complex formation by Bayliss, M. A. J, Gage, R, Edgington, A. M, Venn, R. F

“…HPLC methods with fluorescence detection have been developed for the determination of sulphobutylether-β-cyclodextrin sodium (SBECD), a novel excipient for use…”
Get full text

Clinical analysis of sampatrilat, a combined renal endopeptidase and angiotensin-converting enzyme inhibitor I : Assay in plasma of human volunteers by atmospheric-pressure ionisation mass-spectrometry following derivatisation with BF3-methanol by VENN, R. F, KAYE, B, MACRAE, P. V, SAUNDERS, K. C

“…Sampatrilat is a dual inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) under development for the treatment of hypertension and…”
Get full text

Clinical analysis of sampatrilat, a combined renal endopeptidase and angiotensin-converting enzyme inhibitor: II: Assay in the plasma and urine of human volunteers by dissociation enhanced lanthanide fluorescence immunoassay (DELFIA) by Venn, Richard F, Barnard, Geoff, Kaye, Barry, Macrae, Paul V, Saunders, Kenneth C

“…Sampatrilat is a dual inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) under development for the treatment of hypertension and…”
Get full text

Potential role for P-glycoprotein in the non-proportional pharmacokinetics of UK-343,664 in man by Abel, S, Beaumont, K C, Crespi, C L, Eve, M D, Fox, L, Hyland, R, Jones, B C, Muirhead, G J, Smith, D A, Venn, R F, Walker, D K

“…1. UK-343,664 is a potent and specific PDE5 inhibitor. Following single oral doses to human volunteers, it exhibited non-proportional pharmacokinetics over the…”
Get full text

A potent peptide affinity reagent for the opiate receptor by Venn, R F, Barnard, E A

“…The synthesis and characterization of a novel enkephalin analogue, Tyr-D-Ala-Gly-Phe-Leu-chloromethyl ketone, is described. The biological potency of the…”
Get full text

CSF enkephalins in diabetic neuropathy by Chan, A W, Macfarlane, I A, Masson, E A, Bowsher, D, Morley, J S, Venn, R F

“…CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful…”
Get more information

Persistently increased morphine-6-glucuronide concentrations by Calleja, M A, Childs, D, Venn, R F, Michalkiewicz, A

Get more information

The preparation of stable enzyme-coenzyme complexes with endogenous catalytic activity by Gacesa, P, Venn, R F

“…N6-(6-Aminohexylcarbamoylmethyl)-NAD+ was coupled to lactate dehydrogenase by using glutaraldehyde to form an active complex. The stability of this complex…”
Get full text

Properties of murine anti-morphine antibodies by Glasel, J A, Bradbury, W M, Venn, R F

“…Four lines of high affinity monoclonal antibodies directed against morphine have been isolated and affinity purified. Some of their properties, including…”
Get more information

A specific radioimmunoassay for [Leu] and [Met]enkephalin applied to a HPLC separation of human CSF by Capper, S J, Venn, R F, Morley, J S

“…Highly specific antisera have been raised to [Leu]enkephalin and applied in a radioimmunoassay that is sufficiently sensitive and precise for the measurement…”
Get more information

A rapid binding assay for immunoglobulins which may be used as an alternative to ammonium sulfate precipitation methods by Glasel, J A, Bradbury, W M, Venn, R F

“…This paper describes the conditions under which a short column packed with Sephadex G-25 may be eluted centrifugally to separate labeled ligands from binding…”
Get more information

Opiate binding to subcellular fractions from guinea pig ileum by Glasel, J A, Bradbury, W M, Venn, R F, Reese, J H, Cooper, J R

“…Binding of 3H-etorphine and 3H-D-Ala2-D-Leu5-enkephalin to opiate receptors in synaptosomal and microsomal fractions prepared from guinea pig ileum homogenates…”
Get more information

The sensitivity of opiate receptors and ligands to short wavelength ultraviolet light by Glasel, J A, Venn, R F

Get more information