Search Results - "Venkatesha, Shivaprasad"

The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation by Moudgil, Kamal D, Venkatesha, Shivaprasad H

“…Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation of the immune system. This dysregulation involves an imbalance…”
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Cytokine-modulating strategies and newer cytokine targets for arthritis therapy by Venkatesha, Shivaprasad H, Dudics, Steven, Acharya, Bodhraj, Moudgil, Kamal D

“…Cytokines are the key mediators of inflammation in the course of autoimmune arthritis and other immune-mediated diseases. Uncontrolled production of the…”
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Control of autoimmune inflammation by celastrol, a natural triterpenoid by Venkatesha, Shivaprasad H., Dudics, Steven, Astry, Brian, Moudgil, Kamal D.

“…Celastrol is a bioactive compound derived from traditional Chinese medicinal herbs of the Celastraceae family. Celastrol is known to possess anti-inflammatory…”
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The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response by Dudics, Steven, Venkatesha, Shivaprasad H, Moudgil, Kamal D

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints affecting about 0.3⁻1% of the population in different countries. About 50⁻60 percent of…”
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IL-27-induced modulation of autoimmunity and its therapeutic potential by Meka, Rakeshchandra R, Venkatesha, Shivaprasad H, Dudics, Steven, Acharya, Bodhraj, Moudgil, Kamal D

“…Abstract Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by activated antigen-presenting cells and plays an important role in the…”
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Involvement of the IL-23/IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune arthritis by Astry, Brian, Venkatesha, Shivaprasad H., Moudgil, Kamal D.

“…•IL-17 produced by Th17 cells plays a vital role in the pathogenesis of arthritis.•Th17/Treg imbalance contributes to the initiation and progression of…”
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Peptide-directed liposomal delivery improves the therapeutic index of an immunomodulatory cytokine in controlling autoimmune arthritis by Meka, Rakeshchandra R., Venkatesha, Shivaprasad H., Moudgil, Kamal D.

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial tissue of the joints. Inadequately controlled disease…”
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The miRNA Expression Profile of Experimental Autoimmune Encephalomyelitis Reveals Novel Potential Disease Biomarkers by Venkatesha, Shivaprasad H, Dudics, Steven, Song, Yang, Mahurkar, Anup, Moudgil, Kamal D

“…Multiple sclerosis (MS) is a debilitating autoimmune disease affecting over 2.3 million people worldwide, and it is characterized by inflammation and…”
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Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome by Dudics, Steven, Langan, David, Meka, Rakeshchandra R, Venkatesha, Shivaprasad H, Berman, Brian M, Che, Chun-Tao, Moudgil, Kamal D

“…Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the…”
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Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy by Meka, Rakeshchandra R, Venkatesha, Shivaprasad H, Acharya, Bodhraj, Moudgil, Kamal D

“…Rheumatoid arthritis is an autoimmune disease affecting the joints. Antiarthritic drugs are given systemically, thereby exposing various healthy organs to…”
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Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology by Venkatesha, Shivaprasad H., Moudgil, Kamal D.

“…Objective and design Multiple sclerosis (MS) is a debilitating autoimmune disease involving immune dysregulation of the pathogenic T helper 17 (Th17) versus…”
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Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ by Astry, Brian, Venkatesha, Shivaprasad H, Laurence, Arian, Christensen-Quick, Aaron, Garzino-demo, Alfredo, Frieman, Matthew B, O'Shea, John J, Moudgil, Kamal D

“…Abstract Inflammation is an integral component of autoimmune arthritis. The balance of pathogenic T helper 17 (Th17) and protective T regulatory (Treg) cells…”
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Celastrus-derived Celastrol Suppresses Autoimmune Arthritis by Modulating Antigen-induced Cellular and Humoral Effector Responses by Venkatesha, Shivaprasad H., Yu, Hua, Rajaiah, Rajesh, Tong, Li, Moudgil, Kamal D.

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and articular damage. Proinflammatory cytokines, antibodies, and…”
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Celastrol and Its Role in Controlling Chronic Diseases by Venkatesha, Shivaprasad H, Moudgil, Kamal D

“…Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-inflammatory, antioxidant, and anticancer activities. Celastrol has shown…”
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Pristimerin, a naturally occurring triterpenoid, protects against autoimmune arthritis by modulating the cellular and soluble immune mediators of inflammation and tissue damage by Tong, Li, Nanjundaiah, Siddaraju M, Venkatesha, Shivaprasad H, Astry, Brian, Yu, Hua, Moudgil, Kamal D

“…Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting the synovial joints. The currently available drugs for RA are effective only in a…”
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Suppression of FVIII-Specific Memory B Cells by Chimeric BAR Receptor-Engineered Natural Regulatory T Cells by Pohl, Alessandra De Paula, Venkatesha, Shivaprasad H, Zhang, Ai-Hong, Scott, David W

“…Anti-drug antibody formation poses tremendous obstacles for optimal treatment of hemophilia A (HA). In this study, we sought to utilize chimeric…”
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Celastrus and Its Bioactive Celastrol Protect against Bone Damage in Autoimmune Arthritis by Modulating Osteoimmune Cross-talk by Nanjundaiah, Siddaraju M., Venkatesha, Shivaprasad H., Yu, Hua, Tong, Li, Stains, Joseph P., Moudgil, Kamal D.

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints. Many of the conventional…”
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Engineered ovalbumin-expressing regulatory T cells protect against anaphylaxis in ovalbumin-sensitized mice by Abdeladhim, Maha, Zhang, Ai-Hong, Kropp, Laura E., Lindrose, Alyssa R., Venkatesha, Shivaprasad H., Mitre, Edward, Scott, David W.

“…Allergy is a major public health concern, the main treatment for which is symptomatic relief with anti-inflammatory drugs. A key clinical challenge is to…”
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Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor by Myers Chen, Kayla, Grun, Daniel, Gautier, Brian, Venkatesha, Shivaprasad, Maddox, Michael, Zhang, Ai-Hong, Andersen, Peter

“…Solid cancers Myeloid cells are prevalent in solid cancers, but they frequently exhibit an anti-inflammatory pro-tumor phenotype that contribute to the…”
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Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis by Venkatesha, Shivaprasad H., Berman, Brian M., Moudgil, Kamal D.

“…Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by synovial inflammation, damage to cartilage and bone, and deformities of the…”
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