Search Results - "Venkatesan, Radha"

Precision Diabetes Is Slowly Becoming a Reality by Mohan, Viswanathan, Radha, Venkatesan

“…The concept of precision medicine is becoming increasingly popular. The use of big data, genomics and other “omics” like metabolomics, proteomics and…”
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Clinical features, complications and treatment of rarer forms of maturity-onset diabetes of the young (MODY) - A review by Aarthy, Ramasamy, Aston-Mourney, Kathryn, Mikocka-Walus, Antonina, Radha, Venkatesan, Amutha, Anandakumar, Anjana, Ranjit Mohan, Unnikrishnan, Ranjit, Mohan, Viswanathan

“…Maturity onset diabetes of the young (MODY) is the most common form of monogenic diabetes and is currently believed to have 14 subtypes. While much is known…”
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Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function by Siddiqui, Moneeza K., Anjana, Ranjit Mohan, Dawed, Adem Y., Martoeau, Cyrielle, Srinivasan, Sundararajan, Saravanan, Jebarani, Madanagopal, Sathish K., Taylor, Alasdair, Bell, Samira, Veluchamy, Abirami, Pradeepa, Rajendra, Sattar, Naveed, Venkatesan, Radha, Palmer, Colin N. A., Pearson, Ewan R., Mohan, Viswanathan

“…Aims/hypothesis South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age…”
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A novel stop-loss mutation in NKX2-2 gene as a cause of neonatal diabetes mellitus: molecular characterization and structural analysis by Kavitha, Babu, Srikanth, Kandi, Singh, Deepshikha, Gopi, Sundaramoorthy, Mohan, Viswanathan, Chandra, Nagasuma, Radha, Venkatesan

“…Aim To identify the genetic etiology of neonatal diabetes in an infant and to elucidate the molecular mechanism of the identified mutation underlying the…”
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Identification of appropriate biochemical parameters and cut points to detect Maturity Onset Diabetes of Young (MODY) in Asian Indians in a clinic setting by Aarthy, Ramasamy, Aston-Mourney, Kathryn, Amutha, Anandakumar, Mikocka-Walus, Antonina, Anjana, Ranjit Mohan, Unnikrishnan, Ranjit, Jebarani, Saravanan, Venkatesan, Ulagamathesan, Gopi, Sundaramoorthy, Radha, Venkatesan, Mohan, Viswanathan

“…Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes which is detected by genetic testing. We looked at clinical and biochemcial…”
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Insulin gene mutations linked to permanent neonatal diabetes mellitus in Indian population by Gopi, Sundaramoorthy, Gowri, Palanisamy, Panda, Jayant Kumar, Sathyanarayana, Santhosh Olety, Gupta, Sunil, Chandru, Sundaramoorthy, Chandni, Radhakrishnan, Raghupathy, Palany, Dayal, Devi, Mohan, Viswanathan, Radha, Venkatesan

“…Neonatal diabetes mellitus (NDM) is a rare monogenic disorder of pancreatic beta cell mass and/or function. In the present study we aimed to evaluate the INS…”
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Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine by Kavitha, Babu, Ranganathan, Sampathkumar, Gopi, Sundaramoorthy, Vetrivel, Umashankar, Hemavathy, Nagarajan, Mohan, Viswanathan, Radha, Venkatesan

“…is an essential component of the transcription factor network that controls pancreatic β-cell differentiation, maintenance, and glucose stimulated insulin…”
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Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians by Vimaleswaran, Karani Santhanakrishnan, Bodhini, Dhanasekaran, Jiang, Juanjie, Ramya, Kandaswamy, Mohan, Deepa, Shanthi Rani, Coimbatore Subramanian, Lakshmipriya, Nagarajan, Sudha, Vasudevan, Pradeepa, Rajendra, Anjana, Ranjit Mohan, Mohan, Viswanathan, Radha, Venkatesan

“…Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study,…”
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Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol by Bodhini, Dhanasekaran, Gaal, Szilvia, Shatwan, Israa, Ramya, Kandaswamy, Ellahi, Basma, Surendran, Shelini, Sudha, Vasudevan, Anjana, Mohan R, Mohan, Viswanathan, Lovegrove, Julie A, Radha, Venkatesan, Vimaleswaran, Karani Santhanakrishnan

“…Recent evidence suggests that lifestyle factors influence the association between the Melanocortin 4 receptor (MC4R) and Transcription Factor 7-Like 2 (TCF7L2)…”
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Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21 by TABASSUM, Rubina, CHAUHAN, Ganesh, CHIDAMBARAM, Manickam, SHARMA, Amitabh, CHAVALI, Sreenivas, SENGUPTA, Shantanu, RAMAKRISHNAN, Lakshmi, VENKATESH, Pradeep, AGGARWAL, Sanjay K, GHOSH, Saurabh, PRABHAKARAN, Dorairaj, SRINATH, Reddy K, OM PRAKASH DWIVEDI, SAXENA, Madhukar, BANERJEE, Monisha, MATHUR, Sandeep, BHANSALI, Anil, SHAH, Viral N, SRI VENKATA MADHU, MARWAHA, Raman K, BASU, Analabha, SCARIA, Vinod, MCCARTHY, Mark I, MAHAJAN, Anubha, VENKATESAN, Radha, MOHAN, Viswanathan, TANDON, Nikhil, BHARADWAJ, Dwaipayan, JAISWAL, Alok, KAUR, Ismeet, BANDESH, Khushdeep, SINGH, Tejbir, BENAN JOHN MATHAI, PANDEY, Yogesh

“…Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage…”
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Maternally inherited diabetes and deafness (MIDD)—a series of case reports by Pichakacheri, Sureshkumar, Radha, Venkatesan, Mohan, Viswanathan, Kumar, Sidharth S, Babu, Aishwarya Suresh

“…Introduction Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes, caused by a mutation in the mitochondrial DNA (mtDNA) which impairs…”
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Challenges Involved in Incorporating Personalised Treatment Plan as Routine Care of Patients with Diabetes by Unnikrishnan, Ranjit, Radha, Venkatesan, Mohan, Viswanathan

“…Diabetes is a heterogenous disorder, and patients with this disorder vary considerably in their clinical presentation, response to therapy and risk of…”
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Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India by Mohan, Viswanathan, Radha, Venkatesan, Nguyen, Thong T, Stawiski, Eric W, Pahuja, Kanika Bajaj, Goldstein, Leonard D, Tom, Jennifer, Anjana, Ranjit Mohan, Kong-Beltran, Monica, Bhangale, Tushar, Jahnavi, Suresh, Chandni, Radhakrishnan, Gayathri, Vijay, George, Paul, Zhang, Na, Murugan, Sakthivel, Phalke, Sameer, Chaudhuri, Subhra, Gupta, Ravi, Zhang, Jingli, Santhosh, Sam, Stinson, Jeremy, Modrusan, Zora, Ramprasad, V L, Seshagiri, Somasekar, Peterson, Andrew S

“…Maturity-onset diabetes of the young (MODY) is an early-onset, autosomal dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can…”
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Genotype‐phenotype correlation of KATP channel gene defects causing permanent neonatal diabetes in Indian patients by Gopi, Sundaramoorthy, Kavitha, Babu, Kanthimathi, Sekar, Kannan, Alagarsamy, Kumar, Rakesh, Joshi, Rajesh, Kanodia, Swati, Arya, Archana Dayal, Pendsey, Sanket, Pendsey, Sharad, Raghupathy, Palany, Mohan, Viswanathan, Radha, Venkatesan

“…Background There are very few reports pertaining to Indian patients with neonatal diabetes mellitus (NDM). Activating or gain of function mutations of KATP…”
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Exploring lipodystrophy gene expression in adipocytes: unveiling insights into the pathogenesis of insulin resistance, type 2 diabetes, and clustering diseases (metabolic syndrome) in Asian Indians by Saxena, Aditya, Tiwari, Pradeep, Gupta, Shalu, Mandia, Rajendra, Banshiwal, Ramesh C, Lamoria, Ravinder Kumar, Anjana, Ranjit Mohan, Radha, Venkatesan, Mohan, Viswanathan, Mathur, Sandeep Kumar

“…Studying the molecular mechanisms of lipodystrophy can provide valuable insights into the pathophysiology of insulin resistance (IR), type 2 diabetes (T2D),…”
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Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children by Balamurugan, Kandasamy, Kavitha, Babu, Yang, Zhongying, Mohan, Viswanathan, Radha, Venkatesan, Shyng, Show‐Ling

“…Background Gain‐of‐function of ATP‐sensitive K+ (KATP) channels because of mutations in the genes encoding SUR1 (ABCC8) or Kir6.2 (KCNJ11) is a major cause of…”
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Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population by Wuni, Ramatu, Adela Nathania, Evelyn, Ayyappa, Ashok K, Lakshmipriya, Nagarajan, Ramya, Kandaswamy, Gayathri, Rajagopal, Geetha, Gunasekaran, Anjana, Ranjit Mohan, Kuhnle, Gunter G C, Radha, Venkatesan, Mohan, Viswanathan, Sudha, Vasudevan, Vimaleswaran, Karani Santhanakrishnan

“…Abnormalities in lipid metabolism have been linked to the development of obesity. We used a nutrigenetic approach to establish a link between lipids and…”
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Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population by Vimaleswaran, Karani S, Bodhini, Dhanasekaran, Lakshmipriya, N, Ramya, K, Anjana, R Mohan, Sudha, Vasudevan, Lovegrove, Julie A, Kinra, Sanjay, Mohan, Viswanathan, Radha, Venkatesan

“…Lifestyle factors such as diet and physical activity have been shown to modify the association between fat mass and obesity-associated (FTO) gene variants and…”
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Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults by Alsulami, Sooad, Bodhini, Dhanasekaran, Sudha, Vasudevan, Shanthi Rani, Coimbatore Subramanian, Pradeepa, Rajendra, Anjana, Ranjit Mohan, Radha, Venkatesan, Lovegrove, Julie A, Gayathri, Rajagopal, Mohan, Viswanathan, Vimaleswaran, Karani Santhanakrishnan

“…The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine…”
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Impact of type 2 diabetes variants identified through genome-wide association studies in early-onset type 2 diabetes from South Indian population by Liju, Samuel, Chidambaram, Manickam, Mohan, Viswanathan, Radha, Venkatesan

“…The prevalence of early-onset type 2 diabetes (EOT2D) is increasing in Asian countries. Genome-wide association studies performed in European and various other…”
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