Search Results - "Venkataramanan, Srivats"
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A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X
Published in Molecular systems biology (04-03-2024)“…The road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene…”
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2
DDX3X and DDX3Y are redundant in protein synthesis
Published in RNA (Cambridge) (01-12-2021)“…DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogs and While DDX3X is ubiquitously expressed in human…”
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DDX3 depletion represses translation of mRNAs with complex 5′ UTRs
Published in Nucleic acids research (21-05-2021)“…Abstract DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the yeast ortholog of DDX3, is a global regulator of translation,…”
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4
Determining the impact of stress granule composition on cell survival
Published in Biophysical journal (11-02-2022)Get full text
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The chromatin remodeling complex Swi/Snf regulates splicing of meiotic transcripts in Saccharomyces cerevisiae
Published in Nucleic acids research (27-07-2017)“…Despite its relatively streamlined genome, there are important examples of regulated RNA splicing in Saccharomyces cerevisiae, such as splicing of meiotic…”
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The Traffic Jam: Polyamine Prevalence Pauses Protein Production
Published in Molecular cell (19-04-2018)“…In this issue of Molecular Cell, Ivanov et al. (2018) demonstrate how cells sense metabolite levels and regulate production of their biosynthetic enzymes…”
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Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development
Published in Neuron (Cambridge, Mass.) (06-05-2020)“…De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of unexplained intellectual disability (ID) cases in females and are associated with…”
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The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae
Published in Genes & development (01-04-2017)“…In eukaryotes, a dynamic ribonucleic protein machine known as the spliceosome catalyzes the removal of introns from premessenger RNA (pre-mRNA). Recent studies…”
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The chromatin remodeling complex SWI/SNF is a master regulator of meiotic splicing in Saccharomyces cerevisiae
Published in The FASEB journal (01-04-2016)“…Abstract only Despite its relatively streamlined genome, there are important examples of regulated RNA splicing in Saccharomyces cerevisiae . One of the most…”
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Chromatin-remodeling SWI/SNF complex regulates coenzyme Q6 synthesis and a metabolic shift to respiration in yeast
Published in The Journal of biological chemistry (08-09-2017)“…Despite its relatively streamlined genome, there are many important examples of regulated RNA splicing in Saccharomyces cerevisiae. Here, we report a role for…”
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Control of ribosomal protein synthesis by the Microprocessor complex
Published in Science signaling (23-02-2021)“…Ribosome biogenesis in eukaryotes requires the coordinated production and assembly of 80 ribosomal proteins and four ribosomal RNAs (rRNAs), and its rate must…”
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Nutrient sensing and mitochondrial coenzyme Q biosynthesis: Are they connected by a phosphatase?
Published in The FASEB journal (01-04-2017)“…Abstract only Coenzyme Q (also termed ubiquinone or Q) is an electron carrier in the mitochondrial respiratory chain that functions as an essential component…”
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Nutrient sensing and mitochondrial Coenzyme Q biosynthesis: Are they connected by a phosphatase?
Published in The FASEB journal (01-04-2018)“…Coenzyme Q (also termed ubiquinone or Q) is an electron carrier in the mitochondrial respiratory chain that functions as an essential component in energy…”
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The SWI/SNF Complex Regulates Splicing Outcomes to Determine Cell Fate in Response to Environmental Cues in Saccharomyces cerevisiae
Published 01-01-2017“…Despite its relatively streamlined genome, there are important examples of regulated RNA splicing in Saccharomyces cerevisiae. Here we show crucial roles for…”
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Dissertation -
15
Autoregulation of SUS1: a splicing dependent regulation of histone H2B ubiquitination
Published in The FASEB journal (01-04-2012)“…Abstract only Pre‐messenger RNA splicing is an underappreciated mechanism for regulating gene expression in yeast ( Saccharomyces cerevisiae ), likely due to…”
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Chromatin-remodeling SWI/SNF complex regulates coenzyme Q 6 synthesis and a metabolic shift to respiration in yeast
Published in The Journal of biological chemistry (08-09-2017)“…Despite its relatively streamlined genome, there are many important examples of regulated RNA splicing in Here, we report a role for the chromatin remodeler…”
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Journal Article