Search Results - "Venkatachalam, Annapoorna"

A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia by Murthy, Guru Subramanian Guru, Saliba, Antoine N, Szabo, Aniko, Harrington, Alexandra, Abedin, Sameem, Carlson, Karen, Michaelis, Laura, Runaas, Lyndsey, Baim, Arielle, Hinman, Alex, Maldonado-Schmidt, Sonia, Venkatachalam, Annapoorna, Flatten, Karen S, Peterson, Kevin L, Schneider, Paula A, Litzow, Mark, Kaufmann, Scott H, Atallah, Ehab

“…Azacitidine/venetoclax is an active regimen in patients with newly diagnosed acute myeloid leukemia (AML). However, primary or secondary resistance to…”
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Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors by Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L, Hou, Xianon, Schneider, Paula A, Strathman, Annabella R, Flatten, Karen S, Sine, Chance C, Balczewski, Emily A, McGehee, Cordelia D, Larson, Melissa C, Duffield, Laura N, Meng, X Wei, Vincelette, Nicole D, Ding, Husheng, Oberg, Ann L, Couch, Fergus J, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid…”
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Characterization of a RAD51C -silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance by Hurley, Rachel M, McGehee, Cordelia D, Nesic, Ksenija, Correia, Cristina, Weiskittel, Taylor M, Kelly, Rebecca L, Venkatachalam, Annapoorna, Hou, Xiaonan, Pathoulas, Nicholas M, Meng, X Wei, Kondrashova, Olga, Radke, Marc R, Schneider, Paula A, Flatten, Karen S, Peterson, Kevin L, Becker, Marc A, Wong, Ee Ming, Southey, Melissa S, Dobrovic, Alexander, Lin, Kevin K, Harding, Thomas C, McNeish, Iain, Ross, Christian A, Wagner, Jill M, Wakefield, Matthew J, Scott, Clare L, Haluska, Paul, Wahner Hendrickson, Andrea E, Karnitz, Larry M, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

“…Acquired PARP inhibitor (PARPi) resistance in - or -mutant ovarian cancer often results from secondary mutations that restore expression of functional protein…”
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How CHKing ROS signaling preserves genomic integrity by Venkatachalam, Annapoorna, Kaufmann, Scott H.

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Fine Tuning the Clinical Management of Epithelial Ovarian Cancer by Venkatachalam, Annapoorna

“…Despite the initial favorable outcome to platinum-taxane based chemotherapy, 75-80% of high-grade serous ovarian cancer (HGSOC) patients relapse and develop…”
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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C by Dai, Haiming, Peterson, Kevin L., Flatten, Karen S., Meng, X. Wei, Venkatachalam, Annapoorna, Correia, Cristina, Ramirez-Alvarado, Marina, Pang, Yuan-Ping, Kaufmann, Scott H.

“…How BAK and BAX induce mitochondrial outer membrane (MOM) permeabilization (MOMP) during apoptosis is incompletely understood. Here we have used molecular…”
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Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress by Kelly, Rebecca L., Huehls, Amelia M., Venkatachalam, Annapoorna, Huntoon, Catherine J., Machida, Yuichi J., Karnitz, Larry M.

“…Replication stress impedes DNA polymerase progression causing activation of the ataxia telangiectasia and Rad3-related signaling pathway, which promotes the…”
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AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death by Jia, Jia, Ji, Wenbo, Saliba, Antoine N., Csizmar, Clifford M., Ye, Kaiqin, Hu, Lei, Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Venkatachalam, Annapoorna, Patnaik, Mrinal M., Webster, Jonathan A., Smith, B. Douglas, Ghiaur, Gabriel, Wu, Xinyan, Zhong, Jun, Pandey, Akhilesh, Flatten, Karen S., Deng, Qingmei, Wang, Hongzhi, Kaufmann, Scott H., Dai, Haiming

“…BH3 mimetics, including the BCL2/BCLX L /BCLw inhibitor navitoclax and MCL1 inhibitors S64315 and tapotoclax, have undergone clinical testing for a variety of…”
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Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis by Kir, Devika, Saluja, Manju, Modi, Shrey, Venkatachalam, Annapoorna, Schnettler, Erica, Roy, Sabita, Ramakrishnan, Sundaram

“…Angiogenesis is important for tumor growth and metastasis. Hypoxia in tumors drives this angiogenic response by stabilizing Hypoxia Inducible Factors (HIF) and…”
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Increased expression of collagen prolyl hydroxylases in ovarian cancer is associated with cancer growth and metastasis by Song, Mihae, Schnettler, Erica, Venkatachalam, Annapoorna, Wang, Yujun, Feldman, Lisa, Argenta, Peter, Rodriguez-Rodriguez, Lorna, Ramakrishnan, Sundaram

“…Tumor hypoxia induces collagen deposition and extensive extracellular matrix remodeling, significantly enhancing the processes of invasion and metastasis…”
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CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia by Ding, Husheng, Vincelette, Nicole D, McGehee, Cordelia D, Kohorst, Mira A, Koh, Brian D, Venkatachalam, Annapoorna, Meng, X Wei, Schneider, Paula A, Flatten, Karen S, Peterson, Kevin L, Correia, Cristina, Lee, Sun-Hee, Patnaik, Mrinal, Webster, Jonathan A, Ghiaur, Gabriel, Smith, B Douglas, Karp, Judith E, Pratz, Keith W, Li, Hu, Karnitz, Larry M, Kaufmann, Scott H

“…Although inhibitors of the kinases CHK1, ATR, and WEE1 are undergoing clinical testing, it remains unclear how these three classes of agents kill susceptible…”
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Abstract B098: Impact of dexamethasone on chemotherapy response in ovarian cancer by Venkatachalam, Annapoorna, Correia, Cristina, Mcgehee, Cordelia, Finstuen-Magro, Sarah, Schneider, Paula A., Hurley, Rachel, Peterson, Kevin L., Heinzen, Ethan, Larson, Melissa C., Hou, Xiaonon, Oberg, Ann L., Weroha, Saravut, Kaufmann, Scott H.

“…Abstract Background: Ovarian cancer ranks fifth in cancer deaths among women. The gold standard of care for advanced disease includes cytoreductive surgery…”
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Abstract 5058: Impact of dexamethasone on chemotherapy response in ovarian cancer by Venkatachalam, Annapoorna, Correia, Cristina, Mcgehee, Cordelia D., Finstuen-Magro, Sarah, VanBlaricom, Jamison, Schneider, Paula A., Peterson, Kevin L., Heinzen, Ethan P., Larson, Melissa C., Hou, Xiaonon, Oberg, Ann L., Weroha, Saravut John, Kaufmann, Scott H.

“…Abstract Background: Ovarian cancer ranks fifth in cancer deaths among women. The gold standard of care for advanced disease includes cytoreductive surgery…”
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Abstract B012: Transcriptomic insights reveal role of BCL2 proteins in replication checkpoint inhibitor response by Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L., Hou, Xiaonan, Strathman, Annabella R., Schneider, Paula A, Flatten, Karen S., Duffield, Laura N., McGehee, Cordelia D., Larson, Melissa C., Meng, Xue, Vincelette, Nicole D, Oberg, Ann L., Li, Hu, Weroha, John, Kaufmann, Scott H

“…Abstract Background: The kinases ataxia-telangiectasia-mutated-and-Rad3-related kinase (ATR), checkpoint kinase 1 (CHK1) and WEE1 participate in the response…”
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Effect of mutant Endostatin and Kringle 5 fusion protein on Tumor angiogenesis by Venkatachalam, Annapoorna

“…Angiogenesis is important for the growth and metastasis of tumors. Endostatin is an endogenous inhibitor of angiogenesis and is shown to inhibit bFGF and VEGF…”
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Abstract 1832: CHK1 inhibitor prexasertib induces NOXA-dependent apoptosis in ovarian cancer by Venkatachalam, Annapoorna, Peterson, Kevin L., Correia, Cristina, Flatten, Karen S., Hou, Xianon, Schneider, Paula A., Balczewski, Emily, McGehee, Cordelia, Hurley, Rachel M., Meng, Xue W., Sine, Chance, Shah, Rameen, Vincelettte, Nicole, Ding, Husheng, Li, Hu, Weroha, Saravut (John), Kaufmann, Scott H.

“…Abstract Background: The kinases ataxia-telangiectasia-mutated-and-Rad3-related (ATR), checkpoint kinase 1 (CHK1) and WEE1 participate in the response to…”
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Effect of mutant Endostatin and Kringle 5 fusion protein on Tumor angiogenesis by Venkatachalam, Annapoorna

“…Angiogenesis is important for the growth and metastasis of tumors. Endostatin is an endogenous inhibitor of angiogenesis and is shown to inhibit bFGF and VEGF…”
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