Search Results - "Veniaminova, Natalia A."

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches by Peterson, Shelby C., Eberl, Markus, Vagnozzi, Alicia N., Belkadi, Abdelmadjid, Veniaminova, Natalia A., Verhaegen, Monique E., Bichakjian, Christopher K., Ward, Nicole L., Dlugosz, Andrzej A., Wong, Sunny Y.

“…Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for…”
Get full text

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription by Huang, Jing, Gurung, Buddha, Wan, Bingbing, Matkar, Smita, Veniaminova, Natalia A., Wan, Ke, Merchant, Juanita L., Hua, Xianxin, Lei, Ming

“…Crystal structures of menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1–LEDGF heterodimer, show that menin contains a deep pocket…”
Get full text

Hair Follicle Terminal Differentiation Is Orchestrated by Distinct Early and Late Matrix Progenitors by Mesler, Arlee L., Veniaminova, Natalia A., Lull, Madison V., Wong, Sunny Y.

“…During development and regeneration, matrix progenitors undergo terminal differentiation to form the concentric layers of the hair follicle. These…”
Get full text

Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin by Veniaminova, Natalia A., Grachtchouk, Marina, Doane, Owen J., Peterson, Jamie K., Quigley, David A., Lull, Madison V., Pyrozhenko, Daryna V., Nair, Raji R., Patrick, Matthew T., Balmain, Allan, Dlugosz, Andrzej A., Tsoi, Lam C., Wong, Sunny Y.

“…Oil-secreting sebaceous glands (SGs) are critical for proper skin function; however, it remains unclear how different factors act together to modulate SG stem…”
Get full text

Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury by Veniaminova, Natalia A., Jia, Yunlong Y., Hartigan, Adrien M., Huyge, Thomas J., Tsai, Shih-Ying, Grachtchouk, Marina, Nakagawa, Seitaro, Dlugosz, Andrzej A., Atwood, Scott X., Wong, Sunny Y.

“…Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs…”
Get full text

Hair follicles modulate skin barrier function by Ford, Noah C., Benedeck, Rachel E., Mattoon, Matthew T., Peterson, Jamie K., Mesler, Arlee L., Veniaminova, Natalia A., Gardon, Danielle J., Tsai, Shih-Ying, Uchida, Yoshikazu, Wong, Sunny Y.

“…Our skin provides a protective barrier that shields us from our environment. Barrier function is typically associated with the interfollicular epidermis;…”
Get full text

Butyrate increases IL-23 production by stimulated dendritic cells by Berndt, Bradford E, Zhang, Min, Owyang, Stephanie Y, Cole, Tyler S, Wang, Teresa W, Luther, Jay, Veniaminova, Natalia A, Merchant, Juanita L, Chen, Chun-Chia, Huffnagle, Gary B, Kao, John Y

“…The gut microbiota is essential for the maintenance of intestinal immune homeostasis and is responsible for breaking down dietary fiber into short-chain fatty…”
Get more information

Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct by Swanson, Jacob B., Vagnozzi, Alicia N., Veniaminova, Natalia A., Wong, Sunny Y.

“…The uppermost aspect of the hair follicle, known as the infundibulum or hair canal, provides a passageway for hair shaft egress and sebum secretion. Recent…”
Get full text

Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease by Trieu, Kenneth G., Tsai, Shih-Ying, Eberl, Markus, Ju, Virginia, Ford, Noah C., Doane, Owen J., Peterson, Jamie K., Veniaminova, Natalia A., Grachtchouk, Marina, Harms, Paul W., Swartling, Fredrik J., Dlugosz, Andrzej A., Wong, Sunny Y.

“…Basal cell carcinomas (BCCs) frequently possess immense mutational burdens; however, the functional significance of most of these mutations remains unclear…”
Get full text

ZBP-89 Regulates Expression of Tryptophan Hydroxylase I and Mucosal Defense Against Salmonella Typhimurium in Mice by Essien, Bryan E, Grasberger, Helmut, Romain, Rachael D, Law, David J, Veniaminova, Natalia A, Saqui–Salces, Milena, El–Zaatari, Mohamad, Tessier, Arthur, Hayes, Michael M, Yang, Alexander C, Merchant, Juanita L

“…Background & Aims ZBP-89 (also ZNF148 or Zfp148) is a butyrate-inducible zinc finger transcription factor that binds to GC-rich DNA elements. Deletion of the…”
Get full text

Menin and JunD regulate gastrin gene expression through proximal DNA elements by Mensah-Osman, Edith J, Veniaminova, Natalia A, Merchant, Juanita L

“…Mutations in the MEN1 gene correlate with multiple endocrine neoplasia I (MEN1). Gastrinomas are the most malignant of the neuroendocrine tumors associated…”
Get more information

Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia by Saqui-Salces, Milena, Covés-Datson, Evelyn, Veniaminova, Natalia A, Waghray, Meghna, Syu, Li-Jyun, Dlugosz, Andrzej A, Merchant, Juanita L

“…Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast⁻/⁻) mice develop bacterial overgrowth,…”
Get full text

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration by Veniaminova, Natalia A, Vagnozzi, Alicia N, Kopinke, Daniel, Do, Thy Thy, Murtaugh, L Charles, Maillard, Ivan, Dlugosz, Andrzej A, Reiter, Jeremy F, Wong, Sunny Y

“…The formation of epithelial tubes underlies the development of diverse organs. In the skin, hair follicles resemble tube-like structures with lumens that are…”
Get full text

Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia by Veniaminova, Natalia A, Hayes, Michael M, Varney, Jessica M, Merchant, Juanita L

“…Antral gastrin is the hormone known to stimulate acid secretion and proliferation of the gastric corpus epithelium. Patients with mutations in the multiple…”
Get more information

Sa1811 Generation of Gastric Carcinoids in Mice After Targeted Deletion of Men1 and Somatostatin Gene Loci by Todt, Jill, Tsao, Amy C, Hayes, Michael M, Veniaminova, Natalia A, Saqui-Salces, Milena, Merchant, Juanita L

Get full text

Additional box B of RNA polymerase III promoter in SINE B1 can be functional by Koval, Anastasia P., Veniaminova, Natalia A., Kramerov, Dmitri A.

“…Many genes of small RNAs and short interspersed elements (SINEs) are transcribed by RNA polymerase III due to an internal promoter that is composed of two…”
Get full text

Nucleotide sequences of B1 SINE and 4.5S(I) RNA support a close relationship of zokors to blind mole rats (Spalacinae) and bamboo rats (Rhizomyinae) by Gogolevskaya, Irina K, Veniaminova, Natalia A, Kramerov, Dmitri A

“…Until recently, zokors (Myospalacinae) were assigned to the Cricetidae family. However, analysis of mitochondrial and nuclear genes suggests a sister…”
Get full text

Nucleotide sequences of B1 SINE and 4.5SI RNA support a close relationship of zokors to blind mole rats (Spalacinae) and bamboo rats (Rhizomyinae) by Gogolevskaya, Irina K., Veniaminova, Natalia A., Kramerov, Dmitri A.

“…Until recently, zokors (Myospalacinae) were assigned to the Cricetidae family. However, analysis of mitochondrial and nuclear genes suggests a sister…”
Get full text

Loss of Menin Results in Hypergastrinemia Originating From Antral G Cells by Veniaminova, Natalia A, Merchant, Juanita L

Get full text

B1 SINEs in different rodent families by Veniaminova, Natalia A., Vassetzky, Nikita S., Kramerov, Dmitri A.

“…B1 SINEs were studied in 22 families covering all major rodent lineages. The number of B1 copies considerably varies, from 1 × 10 4 in Geomyidae to 1 × 10 6 in…”
Get full text