Search Results - "Venhorst, J."

Generation of Bayesian prediction models for OATP-mediated drug–drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3 by van de Steeg, E., Venhorst, J., Jansen, H.T., Nooijen, I.H.G., DeGroot, J., Wortelboer, H.M., Vlaming, M.L.H.

“…[Display omitted] Human organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 are important hepatic uptake transporters. Early assessment of…”
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Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats by de Bruin, N.M.W.J., Prickaerts, J., van Loevezijn, A., Venhorst, J., de Groote, L., Houba, P., Reneerkens, O., Akkerman, S., Kruse, C.G.

“…► CMP X and CMP Y are two novel and highly selective 5-HT6 receptor antagonists. ► CMP X and CMP Y improved scopolamine-induced deficits in tests for episodic…”
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The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment by de Bruin, N.M.W.J., van Loevezijn, A., Wicke, K.M., de Haan, M., Venhorst, J., Lange, J.H.M., de Groote, L., van der Neut, M.A.W., Prickaerts, J., Andriambeloson, E., Foley, A.G., van Drimmelen, M., van der Wetering, M., Kruse, C.G.

“…•SLV is a novel highly selective 5-HT6 antagonist.•SLV was studied in animal models for cognitive impairment and social interaction.•SLV was effective at 20…”
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Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: Alternative approaches by Buist, H.E., Devito, S., Goldbohm, R.A., Stierum, R.H., Venhorst, J., Kroese, E.D.

“…•Amine-based post-combustion carbon capture may generate nitrosamines and nitramines.•Predictive models will save animals and allow safety testing to keep up…”
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A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats by de Bruin, N.M.W.J., McCreary, A.C., van Loevezijn, A., de Vries, T.J., Venhorst, J., van Drimmelen, M., Kruse, C.G.

“…▸ CMP 42 is a CNS available, selective 5-HT6 antagonist. ▸ CMP 42 was effective in reducing nicotine self-administration in Wistar rats. ▸ CMP 42 reduced…”
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WITHDRAWN: Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: an alternative approach by Buist, H E, Bausch-Goldbohm, R A, Devito, S, Venhorst, J, Stierum, R H, Kroese, E D

“…This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier…”
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Studies on the inhibition of human cytochromes P450 by selenocysteine Se -conjugates by Venhorst, J., Rooseboom, M., Vermeulen, N. P. E., Commandeur, J. N. M.

“…1. To investigate whether cytochrome P450 (P450) inhibition can contribute to the chemopreventive activity of selenocysteine Se -conjugates (SeCys conjugates),…”
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Development of an intelligence platform for efficient drug Target Safety Assessments by Venhorst, J., van Someren, E.P., van de Brug, F.J., Kalkman, G.J., Folkertsma, S., Krul, C.A.

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A holistic approach to the safety assessment of exploratory drug targets by Venhorst, J., Rouhani Rankouhi, T., Verschuren, L., van Someren, E.P., Kuper, F.C., Wolterbeek, A., van de Brug, F.J., Folkertsma, S., Krul, C.A.M.

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The selective 5-HT 6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment by de Bruin, N.M.W.J., van Loevezijn, A., Wicke, K.M., de Haan, M., Venhorst, J., Lange, J.H.M., de Groote, L., van der Neut, M.A.W., Prickaerts, J., Andriambeloson, E., Foley, A.G., van Drimmelen, M., van der Wetering, M., Kruse, C.G.

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Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities by Venhorst, Jennifer, ter Laak, Antonius M, Commandeur, Jan N. M, Funae, Yoshihiko, Hiroi, Toyoko, Vermeulen, Nico P. E

“…The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1−4 and human CYP2D6, were investigated by measuring IC50 values of 11 known…”
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Identification of Ligand-binding Site III on the Immunoglobulin-like Domain of the Granulocyte Colony-stimulating Factor Receptor by Layton, Judith E., Hall, Nathan E., Connell, Fiona, Venhorst, Jennifer, Treutlein, Herbert R.

“…The granulocyte colony-stimulating factor receptor (G-CSF-R) forms a tetrameric complex with G-CSF containing two ligand and two receptor molecules. The…”
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Design, Synthesis, and Characterization of 7-Methoxy-4-(aminomethyl)coumarin as a Novel and Selective Cytochrome P450 2D6 Substrate Suitable for High-Throughput Screening by Onderwater, Rob C. A, Venhorst, Jennifer, Commandeur, Jan N. M, Vermeulen, Nico P. E

“…In this study, a selective substrate for cytochrome P450 2D6 was designed using a small molecule model developed by M. J. De Groot et al. [(1997) Chem. Res…”
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Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity by VENHORST, Jennifer, ONDERWATER, Rob C. A, MEERMAN, John H. N, COMMANDEUR, Jan N. M, VERMEULEN, Nico P. E

“…A series of six structural analogs of 7-methoxy-4-(aminomethyl)-coumarin (MAMC), a recently developed high-throughput substrate of P450 2D6 (CYP2D6), was…”
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Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin by Venhorst, Jennifer, Onderwater, Rob C.A, Meerman, John H.N, Vermeulen, Nico P.E, Commandeur, Jan N.M

“…We recently reported on the design, synthesis and characterisation of a novel and selective substrate of human cytochrome P450 2D6 (CYP2D6),…”
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The Histamine H1-Receptor Antagonist Binding Site. A Stereoselective Pharmacophoric Model Based upon (Semi-)Rigid H1-Antagonists and Including a Known Interaction Site on the Receptor by ter Laak, Anton M, Venhorst, Jennifer, Donne-Op den Kelder, Gabrielle M, Timmerman, Hendrik

“…A new pharmacophoric model for the H1-antagonist binding site is derived which reveals that a simple atom to atom matching of compounds is not sufficient; in…”
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Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate β-lyase by Venhorst, Jennifer, ter Laak, Antonius M, Meijer, Moira, van de Wetering, Ineke, Commandeur, Jan N.M, Rooseboom, Martijn, Vermeulen, Nico P.E

“…The homodimeric, pyridoxal 5′-phosphate (PLP)-dependent enzyme glutamine transaminase K/cysteine conjugate β-lyase (GTK/β-lyase) has been implicated in the…”
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The histamine H sub(1)-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H sub(1)-antagonists and including a known interaction site on the receptor by Ter Laak, AM, Venhorst, J, Donne-Op Den Kelder, GM, Timmerman, H

“…A new pharmacophoric model for the H sub(1)-antagonist binding site is derived which reveals that a simple atom to atom matching of compounds is not…”
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Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection by De Zwart, Loeckie L, Venhorst, Jennifer, Groot, Marjolein, Commandeur, Jan N.M, Hermanns, Ralph C.A, Meerman, John H.M, Van Baar, Ben L.M, Vermeulen, Nico P.E

“…One of the major processes that occur as a result of radical-induced oxidative stress is lipid peroxidation (LPO). Degradation of lipid peroxides results in…”
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