Search Results - "Vendrell, Marc"
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1
Activatable Fluorophores for Imaging Immune Cell Function
Published in Accounts of chemical research (19-04-2022)“…Conspectus Optical imaging has become an essential tool to study biomolecular processes in live systems with unprecedented spatial resolution. New fluorescent…”
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2
Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles
Published in Journal of the American Chemical Society (21-12-2011)“…We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective…”
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3
Combinatorial Strategies in Fluorescent Probe Development
Published in Chemical reviews (08-08-2012)“…Vendrell et al examine the combinatorial strategies with regard to the development of fluorescent probes…”
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4
Surface-enhanced Raman scattering in cancer detection and imaging
Published in Trends in biotechnology (Regular ed.) (01-04-2013)“…Highlights ► Assays to quantify cancer biomarkers with high sensitivity and low sample volumes. ► Imaging of cancer cells, tissues, and small animals with…”
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5
Modern Synthetic Avenues for the Preparation of Functional Fluorophores
Published in Angewandte Chemie International Edition (27-03-2017)“…Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful…”
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6
Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes
Published in Nature communications (07-06-2021)“…Bioorthogonal late-stage diversification of amino acids and peptides bears enormous potential for drug discovery and molecular imaging. Despite major…”
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7
Quinone-based fluorophores for imaging biological processes
Published in Chemical Society reviews (02-01-2018)“…Quinones are privileged chemical structures playing crucial roles as redox and alkylating agents in a wide range of processes in cells. The broad functional…”
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8
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
Published in Angewandte Chemie International Edition (20-05-2019)“…The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by…”
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9
Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue
Published in Nature communications (09-03-2016)“…Fluorescent antimicrobial peptides are promising structures for in situ , real-time imaging of fungal infection. Here we report a fluorogenic probe to image…”
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10
Are model organisms representative for climate change research? Testing thermal tolerance in wild and laboratory zebrafish populations
Published in Conservation physiology (2019)“…Model organisms can be useful for studying climate change impacts, but it is unclear whether domestication to laboratory conditions has altered their thermal…”
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11
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice
Published in Nature communications (16-09-2023)“…Microglia, the innate immune cells of the central nervous system, actively participate in brain development by supporting neuronal maturation and refining…”
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12
Multicomponent Reactions for de Novo Synthesis of BODIPY Probes: In Vivo Imaging of Phagocytic Macrophages
Published in Journal of the American Chemical Society (30-10-2013)“…Multicomponent reactions are excellent tools to generate complex structures with broad chemical diversity and fluorescent properties. Herein we describe the…”
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13
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
Published in Nature communications (12-08-2020)“…Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The…”
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14
Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell fluorescence imaging
Published in Nature protocols (01-08-2017)“…Fluorescent peptides with excellent target specificity are useful imaging probes. This protocol describes the synthesis of a tryptophan-based fluorogenic amino…”
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15
Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
Published in Nature communications (22-04-2021)“…Photoactivatable molecules enable ablation of malignant cells under the control of light, yet current agents can be ineffective at early stages of disease when…”
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The "Phagocytic Synapse" and Clearance of Apoptotic Cells
Published in Frontiers in immunology (04-12-2017)“…Apoptosis and subsequent phagocytic clearance of apoptotic cells is important for embryonic development, maintenance of tissues that require regular cellular…”
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A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies
Published in Nature communications (02-05-2022)“…Immunotherapy promotes the attack of cancer cells by the immune system; however, it is difficult to detect early responses before changes in tumor size occur…”
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18
Tuning singlet oxygen generation with caged organic photosensitizers
Published in Nature communications (03-09-2024)“…Controlling the succession of chemical processes with high specificity in complex systems is advantageous for widespread applications, from biomedical research…”
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19
Synthesis of a BODIPY Library and Its Application to the Development of Live Cell Glucagon Imaging Probe
Published in Journal of the American Chemical Society (29-07-2009)“…The first BODIPY library (BD) was synthesized, and a highly selective glucagon sensor, Glucagon Yellow (BD-105), was discovered by fluorescence image-based…”
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20
Searching for the Optimal Fluorophore to Label Antimicrobial Peptides
Published in ACS combinatorial science (14-11-2016)“…With the advent of antimicrobial resistance, there is an urgent need for new strategies to treat infectious diseases. Antimicrobial peptides are considered as…”
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