Search Results - "Vender, John"

Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice by Kimbler, Donald E, Shields, Jessica, Yanasak, Nathan, Vender, John R, Dhandapani, Krishnan M

“…Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Cerebral edema, the abnormal accumulation of fluid within the brain…”
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High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4 by Laird, Melissa D., Shields, Jessica S., Sukumari-Ramesh, Sangeetha, Kimbler, Donald E., Fessler, R. David, Shakir, Basheer, Youssef, Patrick, Yanasak, Nathan, Vender, John R., Dhandapani, Krishnan M.

“…Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Cerebral edema, a life‐threatening medical complication, contributes to…”
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Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions by Jarrahi, Abbas, Braun, Molly, Ahluwalia, Meenakshi, Gupta, Rohan V, Wilson, Michael, Munie, Stephanie, Ahluwalia, Pankaj, Vender, John R, Vale, Fernando L, Dhandapani, Krishnan M, Vaibhav, Kumar

“…Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is crucial for developing new therapies for TBI. Current treatments for TBI…”
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White matter damage after traumatic brain injury: A role for damage associated molecular patterns by Braun, Molly, Vaibhav, Kumar, Saad, Nancy M., Fatima, Sumbul, Vender, John R., Baban, Babak, Hoda, Md Nasrul, Dhandapani, Krishnan M.

“…Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity worldwide. Despite decades of pre-clinical investigation, therapeutic…”
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Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury by Vaibhav, Kumar, Braun, Molly, Alverson, Katelyn, Khodadadi, Hesam, Kutiyanawalla, Ammar, Ward, Ayobami, Banerjee, Christopher, Sparks, Tyler, Malik, Aneeq, Rashid, Mohammad H, Khan, Mohammad Badruzzaman, Waters, Michael F, Hess, David C, Arbab, Ali S, Vender, John R, Hoda, Nasrul, Baban, Babak, Dhandapani, Krishnan M

“…Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Preventative measures reduce injury incidence and/or severity, yet one-third of…”
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Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation by Vaibhav, Kumar, Braun, Molly, Khan, Mohammad Badruzzaman, Fatima, Sumbul, Saad, Nancy, Shankar, Adarsh, Khan, Zenab T, Harris, Ruth B S, Yang, Qiuhua, Huo, Yuqing, Arbab, Ali S, Giri, Shailendra, Alleyne, Jr, Cargill H, Vender, John R, Hess, David C, Baban, Babak, Hoda, Md Nasrul, Dhandapani, Krishnan M

“…Spontaneous intracerebral hemorrhage (ICH) produces the highest acute mortality and worst outcomes of all stroke subtypes. Hematoma volume is an independent…”
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Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages - A potential therapeutic approach by Ahluwalia, Meenakshi, Kumar, Manish, Ahluwalia, Pankaj, Rahimi, Scott, Vender, John R., Raju, Raghavan P., Hess, David C., Baban, Babak, Vale, Fernando L., Dhandapani, Krishnan M., Vaibhav, Kumar

“…Mitochondria are dynamic organelles responsible for cellular energy production. Besides, regulating energy homeostasis, mitochondria are responsible for…”
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Activation of Myeloid TLR4 Mediates T Lymphocyte Polarization after Traumatic Brain Injury by Braun, Molly, Vaibhav, Kumar, Saad, Nancy, Fatima, Sumbul, Brann, Darrell W, Vender, John R, Wang, Lei P, Hoda, Md Nasrul, Baban, Babak, Dhandapani, Krishnan M

“…Traumatic brain injury (TBI) is a major public health issue, producing significant patient mortality and poor long-term outcomes. Increasing evidence suggests…”
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Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice by Ahluwalia, Meenakshi, Mcmichael, Hannah, Kumar, Manish, Espinosa, Mario P., Bosomtwi, Asamoah, Lu, Yujiao, Khodadadi, Hesam, Jarrahi, Abbas, Khan, Mohammad Badruzzaman, Hess, David C., Rahimi, Scott Y., Vender, John R., Vale, Fernando L., Braun, Molly, Baban, Babak, Dhandapani, Krishnan M., Vaibhav, Kumar

“…Endocannabinoids [2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA)], endogenously produced arachidonate-based lipids, are anti-inflammatory…”
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Atypical Intracranial Meningioma with Metastasis to C7 Vertebral Body: A Case Report by Ward, Ayobami L., Risman, Aida, Segar, Sharmila, Sharma, Suash, Vender, John R.

“…Extracranial metastasis, mainly a feature of World Health Organization (WHO) grade III meningiomas, is only rarely reported in grade II meningiomas. We report…”
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Overexpression of Nrf2 attenuates Carmustine-induced cytotoxicity in U87MG human glioma cells by Sukumari-Ramesh, Sangeetha, Prasad, Niyathi, Alleyne, Cargill H, Vender, John R, Dhandapani, Krishnan M

“…Malignant glioma is one of the most devastating tumors in adults with poor patient prognosis. Notably, glioma often exhibits resistance to conventional…”
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Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice: Laboratory investigation by WAKADE, Chandramohan, SUKUMARI-RAMESH, Sangeetha, LAIRD, Melissa D, DHANDAPANI, Krishnan M, VENDER, John R

“…Object Traumatic brain injury (TBI) induces significant neurological damage, including deficits in learning and memory, which contribute to a poor clinical…”
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Delayed reduction in hippocampal postsynaptic density protein-95 expression temporally correlates with cognitive dysfunction following controlled cortical impact in mice by Wakade, Chandramohan, Sukumari-Ramesh, Sangeetha, Laird, Melissa D, Dhandapani, Krishnan M, Vender, John R

“…Traumatic brain injury (TBI) induces significant neurological damage, including deficits in learning and memory, which contribute to a poor clinical prognosis…”
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Traumatic Cerebrospinal Fluid Leaks by Prosser, J. Drew, MD, Vender, John R., MD, Solares, C. Arturo, MD

“…This article discusses the epidemiology, diagnosis, and management of traumatic cerebrospinal fluid (CSF) leaks. An overview of traumatic CSF leaks is…”
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A Retrospective Cohort Analysis of Hemorrhagic Arteriovenous Malformations Treated with Combined Endovascular Embolization and Gamma Knife Stereotactic Radiosurgery by Todnem, Nathan, Ward, Ayobami, Nahhas, Michael, Vender, John R., Alleyne, Cargill H., Rahimi, Scott Y.

“…The management of brain arteriovenous malformations (AVMs) remains a controversial topic. Given the relatively low incidence, high heterogeneity, and high…”
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Opposing Roles for Reactive Astrocytes following Traumatic Brain Injury by Laird, Melissa D., Vender, John R., Dhandapani, Krishnan M.

“…Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Current medical therapies exhibit limited efficacy in reducing…”
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Pilot Study of Remote Ischemic Conditioning in Acute Spontaneous Intracerebral Hemorrhage by Jarrahi, Abbas, Shah, Manan, Ahluwalia, Meenakshi, Khodadadi, Hesam, Vaibhav, Kumar, Bruno, Askiel, Baban, Babak, Hess, David C, Dhandapani, Krishnan M, Vender, John R

“…Spontaneous Intracerebral hemorrhage (ICH) is a devastating injury that accounts for 10-15% of all strokes. The rupture of cerebral blood vessels damaged by…”
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Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin‐4? by Laird, Melissa D., Sukumari‐Ramesh, Sangeetha, Swift, Andrew E. B., Meiler, Steffen E., Vender, John R., Dhandapani, Krishnan M.

“…J. Neurochem. (2010) 113, 637–648. Traumatic brain injury is a devastating neurological injury associated with significant morbidity and mortality. Medical…”
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AMPK induces regulatory innate lymphoid cells after traumatic brain injury by Baban, Babak, Braun, Molly, Khodadadi, Hesam, Ward, Ayobami, Alverson, Katelyn, Malik, Aneeq, Nguyen, Khoi, Nazarian, Skon, Hess, David C, Forseen, Scott, Post, Alexander F, Vale, Fernando L, Vender, John R, Hoda, Md Nasrul, Akbari, Omid, Vaibhav, Kumar, Dhandapani, Krishnan M

“…The CNS is regarded as an immunoprivileged organ, evading routine immune surveillance; however, the coordinated development of immune responses profoundly…”
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Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells by Sukumari-Ramesh, Sangeetha, Singh, Nagendra, Jensen, Michael A, Dhandapani, Krishnan M, Vender, John R

“…Pituitary adenomas, which are common intracranial tumors, are associated with significant patient morbidity due to hormone secretion or mass effect or as a…”
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