Search Results - "Vendelin, Marko"

Rat and mouse cardiomyocytes show subtle differences in creatine kinase expression and compartmentalization by Branovets, Jelena, Soodla, Kärol, Vendelin, Marko, Birkedal, Rikke

“…Creatine kinase (CK) and adenylate kinase (AK) are energy transfer systems. Different studies on permeabilized cardiomyocytes suggest that ADP-channelling from…”
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Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice – differences between models, muscles, and sexes by Barsunova, Karina, Vendelin, Marko, Birkedal, Rikke

“…Creatine kinase (CK) functions as an energy buffer in muscles. Its substrate, creatine, is generated by L-arginine:glycine amidinotransferase (AGAT) and…”
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Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges by Kalda, Mari, Vendelin, Marko

“…Strong interactions between cross-bridges (XB) and regulatory units (RU) lead to a steep response of cardiac muscle to an increase in intracellular calcium. We…”
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Simple Analysis of Gel Images With IOCBIO Gel Software by Jaska, Lucia, Birkedal, Rikke, Laasmaa, Martin, Vendelin, Marko

“…Gel image analyses are often difficult to reproduce, as the most commonly used software, the ImageJ Gels plugin, does not automatically record any steps in the…”
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Combined action of albumin and heparin regulates lipoprotein lipase oligomerization, stability, and ligand interactions by Risti, Robert, Gunn, Kathryn H, Hiis-Hommuk, Kristofer, Seeba, Natjan-Naatan, Karimi, Hamed, Villo, Ly, Vendelin, Marko, Neher, Saskia B, Lõokene, Aivar

“…Lipoprotein lipase (LPL), a crucial enzyme in the intravascular hydrolysis of triglyceride-rich lipoproteins, is a potential drug target for the treatment of…”
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Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopy by Vendelin, Marko, Birkedal, Rikke

“…A series of experimental data points to the existence of profound diffusion restrictions of ADP/ATP in rat cardiomyocytes. This assumption is required to…”
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IOCBIO Kinetics: An open-source software solution for analysis of data traces by Vendelin, Marko, Laasmaa, Martin, Kalda, Mari, Branovets, Jelena, Karro, Niina, Barsunova, Karina, Birkedal, Rikke

“…Biological measurements frequently involve measuring parameters as a function of time, space, or frequency. Later, during the analysis phase of the study, the…”
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Simple analysis of gel images with IOCBIO Gel by Kütt, Jaak, Margus, Georg, Kask, Lauri, Rätsepso, Triinu, Soodla, Kärol, Bernasconi, Romain, Birkedal, Rikke, Järv, Priit, Laasmaa, Martin, Vendelin, Marko

“…Abstract Background Current solutions for the analysis of Western Blot images lack either transparency and reproducibility or can be tedious to use if one has…”
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Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes by Sepp, Mervi, Sokolova, Niina, Jugai, Svetlana, Mandel, Merle, Peterson, Pearu, Vendelin, Marko

“…The effective integrated organization of processes in cardiac cells is achieved, in part, by the functional compartmentation of energy transfer processes…”
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Cross-Bridge Group Ensembles Describing Cooperativity in Thermodynamically Consistent Way by Kalda, Mari, Peterson, Pearu, Vendelin, Marko

“…The aim of this work is to incorporate cooperativity into Huxley-type cross-bridge model in thermodynamically consistent way. While the Huxley-type models…”
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Real-time determination of sarcomere length of a single cardiomyocyte during contraction by Peterson, Pearu, Kalda, Mari, Vendelin, Marko

“…Sarcomere length of a cardiomyocyte is an important control parameter for physiology studies on a single cell level; for instance, its accurate determination…”
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Cardiac system bioenergetics: metabolic basis of the Frank-Starling law by Saks, Valdur, Dzeja, Petras, Schlattner, Uwe, Vendelin, Marko, Terzic, Andre, Wallimann, Theo

“…The fundamental principle of cardiac behaviour is described by the Frank-Starling law relating force of contraction during systole with end-diastolic volume…”
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IOCBIO Sparks detection and analysis software by Laasmaa, Martin, Karro, Niina, Birkedal, Rikke, Vendelin, Marko

“…Analysis of calcium sparks in cardiomyocytes can provide valuable information about functional changes of calcium handling in health and disease. As a part of…”
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On the complexity of signal propagation in nerve fibres by Engelbrecht, J, Peets, T, Tamm, K, Laasmaa, M, Vendelin, M

“…Biological systems are characterized by many interwoven processes over multiple scales where interactions between the various phenomena play a decisive role…”
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ADP Compartmentation Analysis Reveals Coupling between Pyruvate Kinase and ATPases in Heart Muscle by Sepp, Mervi, Vendelin, Marko, Vija, Heiki, Birkedal, Rikke

“…Cardiomyocytes have intracellular diffusion restrictions, which spatially compartmentalize ADP and ATP. However, the models that predict diffusion restrictions…”
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ADP protects cardiac mitochondria under severe oxidative stress by Sokolova, Niina, Pan, Shi, Provazza, Sarah, Beutner, Gisela, Vendelin, Marko, Birkedal, Rikke, Sheu, Shey-Shing

“…ADP is not only a key substrate for ATP generation, but also a potent inhibitor of mitochondrial permeability transition pore (mPTP). In this study, we…”
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Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts by Branovets, Jelena, Sepp, Mervi, Kotlyarova, Svetlana, Jepihhina, Natalja, Sokolova, Niina, Aksentijevic, Dunja, Lygate, Craig A, Neubauer, Stefan, Vendelin, Marko, Birkedal, Rikke

“…Disruption of the creatine kinase (CK) system in hearts of CK-deficient mice leads to changes in the ultrastructure and regulation of mitochondrial…”
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Diffusion Restrictions Surrounding Mitochondria: A Mathematical Model of Heart Muscle Fibers by Ramay, Hena R., Vendelin, Marko

“…Several experiments on permeabilized heart muscle fibers suggest the existence of diffusion restrictions grouping mitochondria and surrounding ATPases. The…”
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Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern by Vendelin, Marko, Béraud, Nathalie, Guerrero, Karen, Andrienko, Tatiana, Kuznetsov, Andrey V, Olivares, Jose, Kay, Laurence, Saks, Valdur A

“…The aim of this work was to characterize quantitatively the arrangement of mitochondria in heart and skeletal muscles. We studied confocal images of…”
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Three-dimensional mitochondrial arrangement in ventricular myocytes: from chaos to order by Birkedal, Rikke, Shiels, Holly A, Vendelin, Marko

“…We have developed a novel method to quantitatively analyze mitochondrial positioning in three dimensions. Using this method, we compared the relative…”
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