Search Results - "Velotta, Jonathan P"

Selection on adaptive and maladaptive gene expression plasticity during thermal adaptation to urban heat islands by Campbell-Staton, Shane C., Velotta, Jonathan P., Winchell, Kristin M.

“…Phenotypic plasticity enables a single genotype to produce multiple phenotypes in response to environmental variation. Plasticity may play a critical role in…”
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Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice by Schweizer, Rena M, Velotta, Jonathan P, Ivy, Catherine M, Jones, Matthew R, Muir, Sarah M, Bradburd, Gideon S, Storz, Jay F, Scott, Graham R, Cheviron, Zachary A

“…Evolutionary adaptation to extreme environments often requires coordinated changes in multiple intersecting physiological pathways, but how such multi-trait…”
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Transcriptomic imprints of adaptation to fresh water: parallel evolution of osmoregulatory gene expression in the Alewife by Velotta, Jonathan P., Wegrzyn, Jill L., Ginzburg, Samuel, Kang, Lin, Czesny, Sergiusz, O'Neill, Rachel J., McCormick, Stephen D., Michalak, Pawel, Schultz, Eric T.

“…Comparative approaches in physiological genomics offer an opportunity to understand the functional importance of genes involved in niche exploitation. We used…”
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Trade-offs in osmoregulation and parallel shifts in molecular function follow ecological transitions to freshwater in the Alewife by Velotta, Jonathan P., McCormick, Stephen D., Schultz, Eric T.

“…Adaptation to freshwater may be expected to reduce performance in seawater because these environments represent opposing selective regimes. We tested for such…”
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The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice by Wearing, Oliver H, Ivy, Catherine M, Gutiérrez-Pinto, Natalia, Velotta, Jonathan P, Campbell-Staton, Shane C, Natarajan, Chandrasekhar, Cheviron, Zachary A, Storz, Jay F, Scott, Graham R

“…Abstract Background Complex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions…”
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Relaxed selection causes microevolution of seawater osmoregulation and gene expression in landlocked Alewives by Velotta, Jonathan P, McCormick, Stephen D, O’Neill, Rachel J, Schultz, Eric T

“…Ecological transitions from marine to freshwater environments have been important in the creation of diversity among fishes. Evolutionary changes associated…”
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Comparing the relative amount of testosterone required to restore sexual arousal, motivation, and performance in male rats by Harding, Shannon M., Velotta, Jonathan P.

“…It is well established that male rat reproductive behaviors including sexual arousal, motivation, and performance are dependent on circulating levels of…”
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Network analysis reveals that acute stress exacerbates gene regulatory responses of the gill to seawater in Atlantic salmon by Monette, Michelle Y, Velotta, Jonathan P

“…The transition from freshwater to seawater represents a physiological challenge for Atlantic salmon smolts preparing for downstream migration. Stressors…”
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Remodeling Ancestral Phenotypic Plasticity in Local Adaptation: A New Framework to Explore the Role of Genetic Compensation in the Evolution of Homeostasis by Velotta, Jonathan P., Cheviron, Zachary A.

“…Phenotypic plasticity is not universally adaptive. In certain cases, plasticity can result in phenotypic shifts that reduce fitness relative to the un-induced…”
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Temperature-dependent gene regulatory divergence underlies local adaptation with gene flow in the Atlantic silverside by Jacobs, Arne, Velotta, Jonathan P, Tigano, Anna, Wilder, Aryn P, Baumann, Hannes, Therkildsen, Nina O

“…Gene regulatory divergence is thought to play an important role in adaptation, yet its extent and underlying mechanisms remain largely elusive for local…”
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Genetic variation in HIF‐2α attenuates ventilatory sensitivity and carotid body growth in chronic hypoxia in high‐altitude deer mice by Ivy, Catherine M., Velotta, Jonathan P., Cheviron, Zachary A., Scott, Graham R.

“…The gene encoding HIF‐2α, Epas1, has experienced a history of natural selection in many high‐altitude taxa, but the functional role of mutations in this gene…”
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Repeated Genetic Targets of Natural Selection Underlying Adaptation of Fishes to Changing Salinity by Velotta, Jonathan P, McCormick, Stephen D, Whitehead, Andrew, Durso, Catherine S, Schultz, Eric T

“…Synopsis Ecological transitions across salinity boundaries have led to some of the most important diversification events in the animal kingdom, especially…”
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Maladaptive phenotypic plasticity in cardiac muscle growth is suppressed in high-altitude deer mice by Velotta, Jonathan P., Ivy, Catherine M., Wolf, Cole J., Scott, Graham R., Cheviron, Zachary A.

“…How often phenotypic plasticity acts to promote or inhibit adaptive evolution is an ongoing debate among biologists. Recent work suggests that adaptive…”
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Paralog switching facilitates diadromy: ontogenetic, microevolutionary and macroevolutionary evidence by Colby, Rebecca S., McCormick, Stephen D., Velotta, Jonathan P., Jockusch, Elizabeth, Schultz, Eric T.

“…Identifying how the demands of migration are met at the level of gene expression is critical for understanding migratory physiology and can potentially reveal…”
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Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice by Tate, Kevin B, Ivy, Catherine M, Velotta, Jonathan P, Storz, Jay F, McClelland, Grant B, Cheviron, Zachary A, Scott, Graham R

“…We examined the circulatory mechanisms underlying adaptive increases in thermogenic capacity in deer mice ( ) native to the cold hypoxic environment at high…”
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Adaptive Shifts in Gene Regulation Underlie a Developmental Delay in Thermogenesis in High-Altitude Deer Mice by Velotta, Jonathan P, Robertson, Cayleih E, Schweizer, Rena M, McClelland, Grant B, Cheviron, Zachary A

“…Aerobic performance is tied to fitness as it influences an animal's ability to find food, escape predators, or survive extreme conditions. At high altitude,…”
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Transcriptomic plasticity in brown adipose tissue contributes to an enhanced capacity for nonshivering thermogenesis in deer mice by Velotta, Jonathan P, Jennifer Jones, Cole J. Wolf, Zachary A. Cheviron

“…For small mammals living at high altitude, aerobic heat generation (thermogenesis) is essential for survival during prolonged periods of cold, but is severely…”
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Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice by Ivy, Catherine M, Wearing, Oliver H, Natarajan, Chandrasekhar, Schweizer, Rena M, Gutiérrez-Pinto, Natalia, Velotta, Jonathan P, Campbell-Staton, Shane C, Petersen, Elin E, Fago, Angela, Cheviron, Zachary A, Storz, Jay F, Scott, Graham R

“…Physiological systems often have emergent properties but the effects of genetic variation on physiology are often unknown, which presents a major challenge to…”
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Correction: Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice by Ivy, Catherine M, Wearing, Oliver H, Natarajan, Chandrasekhar, Schweizer, Rena M, Gutiérrez-Pinto, Natalia, Velotta, Jonathan P, Campbell-Staton, Shane C, Petersen, Elin E, Fago, Angela, Cheviron, Zachary A, Storz, Jay F, Scott, Graham R

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UNVEILing connections between genotype, phenotype, and fitness in natural populations by Nelson, Thomas C., Jones, Matthew R., Velotta, Jonathan P., Dhawanjewar, Abhilesh S., Schweizer, Rena M.

“…Understanding the links between genetic variation and fitness in natural populations is a central goal of evolutionary genetics. This monumental task spans the…”
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