Search Results - "Veloso, Anthony J."
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Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma
Published in ACS medicinal chemistry letters (14-11-2013)“…The STAT3 gene is abnormally active in glioblastoma (GBM) and is a critically important mediator of tumor growth and therapeutic resistance in GBM. Thus, for…”
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Rapid Cytotoxicity Screening Platform for Amyloid Inhibitors Using a Membrane-Potential Sensitive Fluorescent Probe
Published in Analytical chemistry (Washington) (02-01-2013)“…The growing interest in membrane interactions of amyloidogenic proteins indicates that lipid binding and the regulation of membrane potential are critical to…”
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3
Disposable electrochemical printed gold chips for the analysis of acetylcholinesterase inhibition
Published in Analytica chimica acta (11-06-2010)“…The detection of trace levels of paraoxon and carbofuran was achieved utilizing differential pulse voltammetry (DPV) on gold disposable electrochemical printed…”
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4
Optical trapping for the characterization of amyloid-beta aggregation kinetics
Published in Analyst (London) (21-10-2011)“…Alzheimer's disease (AD) is marked by the accumulation of neuronal plaques from insoluble amyloid-beta (Aβ) peptides. Growing evidence for the role of Aβ…”
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5
Modulation of fibril formation by a beta-sheet breaker peptide ligand: An electrochemical approach
Published in Bioelectrochemistry (Amsterdam, Netherlands) (01-04-2012)“…The development of generic inhibitors in order to control the formation of amyloid fibrils and early oligomers is still an unmet medical need. Here, we…”
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Electrochemical Immunosensors for Effective Evaluation of Amyloid-Beta Modulators on Oligomeric and Fibrillar Aggregation Processes
Published in Analytical chemistry (Washington) (20-05-2014)“…A novel electrochemical immunosensor fabricated from gold compact disc electrodes was designed for rapid evaluation of aggregation processes that lead to the…”
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7
Surface Plasmon Resonance Imaging of Amyloid‑β Aggregation Kinetics in the Presence of Epigallocatechin Gallate and Metals
Published in Analytical chemistry (Washington) (19-02-2013)“…A number of human protein misfolding disorders, including Alzheimer’s disease (AD), are closely related to the accumulation of β-sheet-rich amyloid fibrils or…”
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8
Electrochemical detection of perchloroethylene using differential pulse voltammetry
Published in Electrochemistry communications (01-12-2013)“…We demonstrate the application of differential pulse voltammetry (DPV) for the electrochemical detection of perchloroethylene (PCE) on an unmodified glassy…”
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9
Disposable Immunochips for the Detection of Legionella pneumophila Using Electrochemical Impedance Spectroscopy
Published in Analytical chemistry (Washington) (17-04-2012)“…The rapid diagnosis of Legionellosis is crucial for the effective treatment of this disease. Currently, most clinical laboratories utilize rapid immunoassays…”
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10
Miniaturized electrochemical system for cholinesterase inhibitor detection
Published in Analytica chimica acta (24-04-2013)“…[Display omitted] ► Acetylcholinesterase inhibitor activity was measured on label-free electrodes. ► Electrochemical detection was validated against Ellman's…”
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Electrochemical impedance spectroscopy for monitoring caspase-3 activity
Published in Electrochimica acta (20-04-2015)“…[Display omitted] •Peptide film was immobilized on a screen-printed gold electrode.•Caspase-3 activity was detected using electrochemical impedance…”
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12
Reflection spectroscopy for the determination of Au nanostructure formation on carbon surfaces
Published in Talanta (Oxford) (30-10-2011)“…► Reflectance spectroscopy of electrodeposited Au nanoparticles is monitored on chips. ► Impedance spectroscopy and cyclic voltammetry were used to…”
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13
Insight into Amyloid Formation Using Congo Red as the Electrochemical Probe
Published in Electroanalysis (New York, N.Y.) (01-12-2011)“…The amyloid‐β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer’s disease (AD). The…”
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14
Electroanalysis of the interaction between (-)-epigallocatechin-3-gallate (EGCG) and amyloid-β in the presence of copper
Published in Metallomics (01-03-2013)“…The misfolding of amyloid-beta (Aβ) peptide is one of the pathological hallmarks of Alzheimer's disease (AD). Polyphenols are strong antioxidants and metal…”
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15
sym-Triazines for Directed Multitarget Modulation of Cholinesterases and Amyloid‑β in Alzheimer’s Disease
Published in ACS chemical neuroscience (20-02-2013)“…Alzheimer’s disease (AD) is a complex neurodegenerative disorder marked by numerous causative factors of disease progression, termed pathologies. We report…”
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Biological Activity of sym-Triazines with Acetylcholine-like Substitutions as Multitarget Modulators of Alzheimer’s Disease
Published in ACS chemical neuroscience (19-06-2013)“…The bioactivities of two novel compounds (TAE-1 and TAE-2) that contain a sym-triazine scaffold with acetylcholine-like substitutions are examined as promising…”
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17
Analysis of Amyloid Beta Aggregation Kinetics Using Sym-Triazine β-Sheet Inhibitors
Published in Electroanalysis (New York, N.Y.) (01-09-2012)“…AD (Alzheimer’s disease) is a progressive neurodegenerative disorder characterized by the cerebral accumulation of fibrillar amyloid‐beta (Aβ) aggregates. Here…”
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18
Surface Plasmon Resonance Imaging of Amyloid-[Beta] Aggregation Kinetics in the Presence of Epigallocatechin Gallate and Metals
Published in Analytical chemistry (Washington) (19-02-2013)“…A number of human protein misfolding disorders, including Alzheimer's disease (AD), are closely related to the accumulation of β-sheet-rich amyloid fibrils or…”
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19
Analysis of Amyloid Beta Aggregation Kinetics Using Sym-Triazine P-Sheet Inhibitors
Published in Electroanalysis (New York, N.Y.) (01-09-2012)“…AD (Alzheimer's disease) is a progressive neurodegenerative disorder characterized by the cerebral accumulation of fibrillar amyloid-beta (AP) aggregates. Here…”
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Electroanalysis of the interaction between (−)-epigallocatechin-3-gallate (EGCG) and amyloid-β in the presence of copperElectronic supplementary information (ESI) available: Additional experimental data and figures. See DOI: 10.1039/c3mt20106f
Published 27-03-2013“…The misfolding of amyloid-beta (Aβ) peptide is one of the pathological hallmarks of Alzheimer's disease (AD). Polyphenols are strong antioxidants and metal…”
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