Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil

Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil

The anti-HCV antibody response has not been well characterized during the early phase of HCV infection and little is known about its relationship to the clinical course during this period. We analyzed serial anti-HCV antibodies longitudinally obtained from a prospective cohort of 65 patients with ac...

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Published in:BMC infectious diseases Vol. 11; no. 1; p. 15
Main Authors: Strasak, Alexander M, Kim, Arthur Y, Lauer, Georg M, de Sousa, Paulo S, Ginuino, Cleber F, Fernandes, Carlos A, Velloso, Carlos E, de Almeida, Adilson J, de Oliveira, Jaqueline M, Yoshida, Clara F, Schulze zur Wiesch, Julian, Paranhos-Baccalá, Gláucia, Lang, Stefan, Brant, Larry J, Ulmer, Hanno, Strohmaier, Susanne, Kaltenbach, Lalit, Lampe, Elisabeth, Lewis-Ximenez, Lia L
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 12-01-2011
BioMed Central
BMC
Subjects:
Adult
Aged
Anti-antibodies
Antibodies
Brazil
Cohort Studies
Development and progression
Disease
Female
Follow-Up Studies
Hepacivirus - genetics
Hepacivirus - immunology
Hepacivirus - isolation & purification
Hepatitis C
Hepatitis C - immunology
Hepatitis C - virology
Hepatitis C Antibodies - immunology
Hepatitis C virus
Hospitals
Humans
Immune response
Infections
Laboratories
Male
Measurement
Middle Aged
Patients
Physiological aspects
Ratios
Risk exposure
RNA, Viral - blood
RNA, Viral - genetics
Young Adult
Brazil
Rio de Janeiro Brazil
Austria
United States > US
Massachusetts
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Summary:The anti-HCV antibody response has not been well characterized during the early phase of HCV infection and little is known about its relationship to the clinical course during this period. We analyzed serial anti-HCV antibodies longitudinally obtained from a prospective cohort of 65 patients with acute HCV infection by using a microparticle enzyme immunoassay AxSYM HCV 3.0 (Abbott Diagnostics) during the first 12 months from HCV acquisition in Rio de Janeiro, Brazil. Spontaneous viral clearance (SVC) was defined as undetectable HCV RNA in serum, in the absence of treatment, for three consecutive HCV PCR tests within 12-months of follow-up. Baseline antibody values were similar among patient groups with self-limiting HCV evolution (n = 34) and persistent viremia (n = 31) [median (interquartile range) signal/cut-off ratio (s/co) 78.7 (60.7-93.8) vs. 93.9 (67.8-111.9), p = 0.26]. During 12-months follow-up, patients with acute spontaneous resolving HCV infection showed significantly lower serial antibody response in comparison to individuals progressing to chronic infection [median (interquartile range) s/co 62.7 (35.2-85.0) vs. 98.4 (70.4-127.4), p < 0.0001]. In addition, patients with self-limiting HCV evolution exhibited an expeditious, sharp decline of serial antibody values after SVC in comparison to those measured before SVC [median (interquartile range) s/co 56.0 (25.4-79.3) vs. 79.4 (66.3-103.0), p < 0.0001]. Our findings indicate a rapid short-term decline of antibody values in patients with acute spontaneous resolving HCV infection.
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ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-11-15